DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and Rnh1

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001165572.1	Gene:	Rnh1 / 107702	MGIID:	1195456	Length:	492	Species:	Mus musculus

Alignment Length:	530	Identity:	128/530 - (24%)
Similarity:	194/530 - (36%)	Gaps:	144/530 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 FRGLKAAHMRLSHETLERILHVLKRSMWLEELH----------LEALG-LRWDFLNKL------- 277
            |||.:.. :|:...:|...|:.. :|.|...||          .|.|. .||..|..|
Mouse     2 FRGARLP-LRVFFGSLPGPLNTW-QSGWTRRLHCAPTMSLDIQCEQLSDARWTELLPLIQQYEVV 64

  Fly   278 -------------SISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVS 329
                         .||....:|||:..:.|..|.:.|.|.       |.::||   |..|..|:.
Mouse    65 RLDDCGLTEVRCKDISSAVQANPALTELSLRTNELGDGGV-------GLVLQG---LQNPTCKIQ 119

  Fly   330 KGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNSLKD-DITNLHNFLAQPNV-LE 392
                ||:|.:||||..|...:...|   :|:| :|..|.|:.|.:.| .:..|...|..|.. ||
Mouse   120 ----KLSLQNCGLTEAGCGILPGML---RSLS-TLRELHLNDNPMGDAGLKLLCEGLQDPQCRLE 176

  Fly   393 HLDLASTDITLENL--FGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNI 455
            .|.|...::|..:.  ..::|| .......|.:|:|.......:.:....|.   |...|:.|.:
Mouse   177 KLQLEYCNLTATSCEPLASVLR-VKADFKELVLSNNDLHEPGVRILCQGLKD---SACQLESLKL 237

  Fly   456 AGCKLPMEALKNLLLGLACN--ESTAGLY-LDLSSNTLGAQGAHVL------------------- 498
            ..|.:.....|:|     |:  .|.|.|. ||||||.||..|...|
Mouse   238 ENCGITAANCKDL-----CDVVASKASLQELDLSSNKLGNAGIAALCPGLLLPSCKLRTLWLWEC 297

  Fly   499 ----ESCIHGVRVLQS------LDISDNNLDAELAPVLTAISKNPSIRTLHL---TRSLTGMKPK 550
                |.|....|||::      |.::.|.|..|.|.:|......|..:...|   |.|||.....
Mouse   298 DITAEGCKDLCRVLRAKQSLKELSLASNELKDEGARLLCESLLEPGCQLESLWIKTCSLTAASCP 362

  Fly   551 HIPPVMDALVNLIQKDDFPLVELVLSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLL 615
            :                                   |.:.|..::||.:|.:|.|.:||.|.:.|
Mouse   363 Y-----------------------------------FCSVLTKSRSLLELQMSSNPLGDEGVQEL 392

  Fly   616 AKAL-QINNRLRTIYMDKNGVTLQGYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMR 679
            .||| |.:..||.:::....||..|.:.:...|..|.|:|.:     |::.:....|    .|::
Mouse   393 CKALSQPDTVLRELWLGDCDVTNSGCSSLANVLLANRSLREL-----DLSNNCMGGP----GVLQ 448

  Fly   680 KMQELLQRNC 689
            .::.|.|.:|
Mouse   449 LLESLKQPSC 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	87/351 (25%)
		leucine-rich repeat	289..331	CDD:275381	10/41 (24%)
		leucine-rich repeat	332..352	CDD:275381	8/19 (42%)
		leucine-rich repeat	364..389	CDD:275380	7/25 (28%)
		leucine-rich repeat	391..417	CDD:275380	7/27 (26%)
		leucine-rich repeat	418..449	CDD:275380	5/30 (17%)
		LRR_RI	441..>656	CDD:238064	62/250 (25%)
		leucine-rich repeat	450..467	CDD:275380	3/16 (19%)
		leucine-rich repeat	468..503	CDD:275380	17/60 (28%)
		leucine-rich repeat	508..534	CDD:275380	7/31 (23%)
		leucine-rich repeat	535..564	CDD:275380	5/31 (16%)
		leucine-rich repeat	570..596	CDD:275380	2/25 (8%)
		leucine-rich repeat	597..618	CDD:275380	8/20 (40%)
		CARMIL_C	797..1108	CDD:292619
Rnh1	NP_001165572.1	LRR_RI	37..356	CDD:238064	85/345 (25%)
		leucine-rich repeat	38..60	CDD:275380	6/21 (29%)
		LRR	<46..361	CDD:227223	87/341 (26%)
		leucine-rich repeat	61..88	CDD:275380	3/26 (12%)
		leucine-rich repeat	89..113	CDD:275380	8/33 (24%)
		leucine-rich repeat	118..145	CDD:275380	11/34 (32%)
		leucine-rich repeat	146..174	CDD:275380	8/27 (30%)
		leucine-rich repeat	175..198	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..231	CDD:275380	5/30 (17%)
		leucine-rich repeat	232..259	CDD:275380	7/31 (23%)
		leucine-rich repeat	260..288	CDD:275380	11/27 (41%)
		leucine-rich repeat	289..309	CDD:275380	2/19 (11%)
		leucine-rich repeat	317..336	CDD:275380	5/18 (28%)
		leucine-rich repeat	346..373	CDD:275380	7/61 (11%)
		LRR_RI	371..398	CDD:197686	12/26 (46%)
		leucine-rich repeat	374..397	CDD:275380	10/22 (45%)
		leucine-rich repeat	403..430	CDD:275380	7/26 (27%)
		LRR_RI	428..455	CDD:197686	7/35 (20%)
		leucine-rich repeat	431..452	CDD:275380	4/29 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930