DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRR and carmil3

DIOPT Version :9

Sequence 1:	NP_001260788.1	Gene:	LRR / 35715	FlyBaseID:	FBgn0033212	Length:	1486	Species:	Drosophila melanogaster
Sequence 2:	NP_001304694.1	Gene:	carmil3 / 100537031	ZFINID:	ZDB-GENE-070912-183	Length:	1384	Species:	Danio rerio

Alignment Length:	1501	Identity:	428/1501 - (28%)
Similarity:	700/1501 - (46%)	Gaps:	251/1501 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTKDLNESVKSILGRHTKILVKYMVKLETKGDKTENRVLVFTPVRVYLLSAKVPTKIECHFHYLD 71
            :::::.||::.::.: |.|.:...:|.|.|..|:|:|:||....|:||::.|:|||:|..|::|:
Zfish    14 VSREMTESIRRVIDK-TSIKLVRAIKAENKSGKSEDRILVLATWRMYLMAPKIPTKVEQTFNFLE 77

  Fly    72 IVGVESKKSTHFSIVTNDRPYSFVTTGDAGNFSSVRHNHLLNADVILTDLASAIKQIFPTVPLKY 136
            |..:.:.......|.|:...||.       ...|..|     .|.::..:..|:.:||..
Zfish    78 IRAMNTHPENQVVIETDKSTYSL-------RLQSNEH-----LDQMINHINFALSRIFNN----- 125

  Fly   137 IIRKIDIQPPERETIF---------SEEFRPSDPRNV---GPCGGFSAQYACMCDFHGVPYREEV 189
                 .|..|   :||         :.:|.||...:|   ..|||||..||.:||::|:..:|||
Zfish   126 -----SIYTP---SIFHADGDVADGNRKFSPSSESSVETQRACGGFSETYAALCDYNGITCKEEV 182

  Fly   190 AWDVDTIYLSHDTRVLNLRDFDHLEPKDLMAIVSALEYNTFFRGLKAAHMRLSHETLERILHVLK 254
            .|||||||.|.|.|..||.||.|||..||..||:|:.||::|..|.....|:|.|.:|:|||.:.
Zfish   183 QWDVDTIYHSQDNREFNLLDFSHLESGDLAVIVAAMAYNSWFIKLYCKDFRISSEVVEQILHTVS 247

  Fly   255 RSMWLEELHLEALGLRWDFLNKLSISVITNSNPAIRTIDLSHNIIEDKGASSLCALFGKIVQGAI 319
            :|..||||.||.:||:.||..|::.::..|....|.:|:|:||.::::|.|:|       :|
Zfish   248 KSSSLEELTLENVGLKADFPQKMATALSENPASVIHSINLAHNTLDNQGVSNL-------IQ--- 302

  Fly   320 HLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHSLTLNQSISNSLTYLDLSGNS---LKDDITNL 381
                .:.::||||..|.|:...|:||||..:|.:|..:...||||.:||||.|.   ..:|.|||
Zfish   303 ----QVCRLSKGLRLLNLSKTSLSSKGVTSLSQALCSSDDYSNSLLHLDLSKNPGILSGEDATNL 363

  Fly   382 HNFLAQPNVLEHLDLASTDITLENLFGALLRGCATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTS 446
            :.||||||.|.||||:.||.|:::|||||||||...|::||:|.||||.:|.:|..|||:|||:|
Zfish   364 YLFLAQPNCLVHLDLSGTDCTVDSLFGALLRGCCADLSYLNLSKNSFSHRKVRETLPSFRQFFSS 428

  Fly   447 TFSLKHLNIAGCKLPMEALKNLLLGLACNESTAGLYLDLSSNTLGAQGAHVLESCIHGVRVLQSL 511
            .|||.|:::|..|:|.:.|:.|.|||:.|.....|:||:|...|.:.||.:::.....|..:.:|
Zfish   429 AFSLTHISLASMKMPPDVLRALFLGLSSNPHITDLHLDISGCELRSAGAGIIQDLFPRVSCISTL 493

  Fly   512 DISDNNLDAELAPVLTAISKNPSIRTLHLTRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELVLS 576
            |||||.||.:|..|:.|.|::||::.|.|.::. .:|.:.:..|:..||:|:|:::..|..|.|:
Zfish   494 DISDNGLDGDLLCVIPAFSRHPSLKHLLLGKNF-NIKGRVLDEVLQKLVHLVQEEECALQSLSLA 557

  Fly   577 ENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQINNRLRTIYMDKNGVTLQGYA 641
            :::|:......:||||||..|:|:|:|||.:.|.|||:|:||||||..||::..|:|..:..|:.
Zfish   558 DSRLRSRGTVLVNALGSNACLKKVDLSGNGLDDTGARMLSKALQINTTLRSVTWDRNNTSATGFQ 622

  Fly   642 DIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNCNGLKRATGQGFRLQHGF 706
            |:..|||||.:::.:|.|:.|:....:|.||:|:..:.|:|..|.||....:.:..|..||..|.
Zfish   623 DVARALEHNFTLQYMPIPLSDVTQAYRSSPDRTEQALTKIQRALLRNNQTQRFSQKQALRLHQGL 687

  Fly   707 MLSSTHQLVDKLVAETQDTISLAK--GGSESASAVQRLITDAENCKQLMPKLQEA--VRNESHPI 767
            :.|:..|::::|....|..:.:.:  |..|...|.::::.:|.|.:.|.|.|.|.  |.:...|:
Zfish   688 VTSTAEQVMERLCVRVQQQVCVLRGTGEGEELQAARQVLKEARNSRALYPSLCELAHVLSVDGPV 752

  Fly   768 EMKMTRVASELSYTIKSYLEETMETMMRTGIEQCPKTLGNQIVVQDLRKALAERLVVPEEFLQIC 832
            ..::..:|.||:......|:..:::|:....|.||.:......:.....:::||:.:|...::..
Zfish   753 RQRLDSLAGELAKAADKELQVIVDSMVSLCRELCPLSCAAAECLSPPLSSISERVSIPRSSIRTA 817

  Fly   833 LLNNAGSEIMNKVGEIEQSLAAAISDRATDEVLEALTRYRRGMGIAESPSVLLDEPQTPDIVRSR 897
            |:..|..:|...:.|::.|:.:.:::...|::|:.|....:.:....|....|::..|     :|
Zfish   818 LMERAAQDINRALEEVKLSVVSYLTNSIVDQILQELYATHKTLLRQVSQMRRLEDGGT-----AR 877

  Fly   898 SSH-DADGLIIRPGGRGSILPKLGLESPTKLEYLNLATPHLPTKRRSLAKKVRPQSVVENLSLGH 961
            .:| .||.|.:.....|..:..:.::                 ||.|..:::||  |...||||.
Zfish   878 RAHRHADMLDVVEDDFGISIDTIAIK-----------------KRSSRTRRIRP--VSNRLSLGE 923

  Fly   962 FPDLLESPSSHRSNSQLSARAAAGAAALVGAANMTDSIAVDDGGVDECCDSITELPSASFQLQHL 1026
            .|:.....|:.:|::.||..|:                          .:.:..||:....|:|:
Zfish   924 DPNSSPLVSTPQSSAPLSRSAS--------------------------WEGLATLPTQGSPLRHV 962

  Fly  1027 --VKGRPKRAKTRAPTRPLVTTECA--GGSREIGEGLEHFFRPGSVTPTTLTPLVSPTSEECSSL 1087
              |:.||.| :.||...|. .|.|:  ||...:.:||..|:          |..|.|.|:
Zfish   963 THVRPRPPR-RHRAAHAPF-ETHCSENGGVSLLDDGLPDFY----------TKRVLPDSQ----- 1010

  Fly  1088 SFVDSPTMSRDGNGHMTSEETTPILEERRPIKLERQSPLLKSASWATRSRSTDNLEKYSPLVGRK 1152
                           ::|......|..::     |:|.|...:.:.....||.:.::..|
Zfish  1011 ---------------LSSHHHAQALRRKK-----RRSVLSIFSGFRKNRNSTISYQEPDP----- 1050

  Fly  1153 SPLVKMRTEGGPGSGSATGAE-ETSMPSSNLLKATAR-EDKTRSPSSDSIKSHAAGEGSVIVKTG 1215
                       .|.|.|.|.| .|::.:.|:...... :|:.|...|.        ||:.....|
Zfish  1051 -----------TGRGGACGEECRTNIATENVYSLIQHPKDRGRLDGST--------EGTNGRLVG 1096

  Fly  1216 NGILRTPIVLQKPRPWSVVGSEPKAGGDLITGNGNADSSKTTPDKLEEDDVEIVTFGNTCSGSIV 1280
            .|:.|||.:..:|     |...|..|  ::..:.:..|.:.:||..|       .||   |...:
Zfish  1097 PGVQRTPQLSGRP-----VQGIPLPG--MMGISPSCFSHRQSPDYSE-------VFG---SSEEI 1144

  Fly  1281 GITPGIALSTSGGGSIV--GITP------GGALEKKSVRELAAG-------LNRMELPLKPPVMP 1330
            |....   .|.....||  |.||      .|..|.:|..:..|.       |...:.|..||
Zfish  1145 GYREH---ETDRHSDIVAKGHTPSIDRQESGRQESQSDSQKKADGVIDPQLLETRKRPDPPP--- 1203

  Fly  1331 RTLLNATSVRTSTSSTGSTSNSVSVSSSTNANTSMTVLNQSQTRSRI---VSSTSSTDSTETITE 1392
                  .|.:.|.:.|.......|...||..:..:...::.:...|.   :........|..|.|
Zfish  1204 ------QSTKPSLAKTRQRHLEESSDKSTEDSGELREKDEEKENGRCGEDLKDQKPQGQTPLIPE 1262

  Fly  1393 RST-----TSTSSSSSSSYEKQHAKACAN-----------------LISNEILSMRNGQL----G 1431
            :..     ||...||......:|....|.                 |..:||.|...|.:    .
Zfish  1263 KPCYYSPHTSPIGSSPHDVANEHQPPAAPPTSAKPVFHSTSVDSALLQGDEIKSSPGGPMKPHRN 1327

  Fly  1432 AKSGSC 1437
            .|:.||
Zfish  1328 RKANSC 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	LRR_RI	198..516	CDD:238064	139/320 (43%)
		leucine-rich repeat	289..331	CDD:275381	10/41 (24%)
		leucine-rich repeat	332..352	CDD:275381	8/19 (42%)
		leucine-rich repeat	364..389	CDD:275380	14/27 (52%)
		leucine-rich repeat	391..417	CDD:275380	17/25 (68%)
		leucine-rich repeat	418..449	CDD:275380	17/30 (57%)
		LRR_RI	441..>656	CDD:238064	85/214 (40%)
		leucine-rich repeat	450..467	CDD:275380	6/16 (38%)
		leucine-rich repeat	468..503	CDD:275380	12/34 (35%)
		leucine-rich repeat	508..534	CDD:275380	12/25 (48%)
		leucine-rich repeat	535..564	CDD:275380	7/28 (25%)
		leucine-rich repeat	570..596	CDD:275380	10/25 (40%)
		leucine-rich repeat	597..618	CDD:275380	11/20 (55%)
		CARMIL_C	797..1108	CDD:292619	62/315 (20%)
carmil3	NP_001304694.1	LRR_RI	<226..410	CDD:238064	84/197 (43%)
		leucine-rich repeat	311..342	CDD:275381	11/30 (37%)
		leucine-rich repeat	343..372	CDD:275381	15/28 (54%)
		LRR_RI	367..629	CDD:238064	116/262 (44%)
		leucine-rich repeat	373..399	CDD:275381	17/25 (68%)
		leucine-rich repeat	400..431	CDD:275381	17/30 (57%)
		leucine-rich repeat	432..459	CDD:275381	11/26 (42%)
		leucine-rich repeat	460..516	CDD:275381	20/55 (36%)
		leucine-rich repeat	517..542	CDD:275381	5/25 (20%)
		leucine-rich repeat	578..599	CDD:275380	11/20 (55%)
		CARMIL_C	783..1039	CDD:292619	66/342 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575242
Domainoid	1	1.000	50	1.000	Domainoid score	I11682
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208951at2759
OrthoFinder	1	1.000	-	-		FOG0002311
OrthoInspector	1	1.000	-	-		otm25769
orthoMCL	1	0.900	-	-		OOG6_103674
Panther	1	1.100	-	-	O	PTHR24112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2004
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900