DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRR and Rnh1

DIOPT Version :9

Sequence 1:NP_001260788.1 Gene:LRR / 35715 FlyBaseID:FBgn0033212 Length:1486 Species:Drosophila melanogaster
Sequence 2:NP_001257691.1 Gene:Rnh1 / 100360501 RGDID:621398 Length:492 Species:Rattus norvegicus


Alignment Length:506 Identity:121/506 - (23%)
Similarity:178/506 - (35%) Gaps:142/506 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   255 RSMWLEELH----------LEALG-LRWDFLNKL--------------------SISVITNSNPA 288
            :|:|...||          .|.|. .||..|..|                    .|.....:|||
  Rat    24 QSVWTRRLHCAPTMSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPA 88

  Fly   289 IRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHS 353
            :..:.|..|.:.|.|.       |.::||   |..|..|:.    ||:|.:|.||..|...:...
  Rat    89 LTELSLRTNELGDAGV-------GLVLQG---LQNPTCKIQ----KLSLQNCSLTEAGCGVLPDV 139

  Fly   354 LTLNQSISNSLTYLDLSGNSLKDD-ITNLHNFLAQPNV-LEHLDLASTDITLENL--FGALLRGC 414
            |   :|:| :|..|.|:.|.|.|: :..|...|..|.. ||.|.|...::|..:.  ..::|| .
  Rat   140 L---RSLS-TLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLR-V 199

  Fly   415 ATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACN--ES 477
            ......|.:|:|.|.......:....|.   |...|:.|.:..|.:.....|:|     |:  .|
  Rat   200 KPDFKELVLSNNDFHEAGIHTLCQGLKD---SACQLESLKLENCGITSANCKDL-----CDVVAS 256

  Fly   478 TAGLY-LDLSSNTLGAQGAHVL-----------------------ESCIHGVRVLQS------LD 512
            .|.|. |||.||.||..|...|                       |.|....|||::      |.
  Rat   257 KASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELS 321

  Fly   513 ISDNNLDAELAPVLTAISKNPSIRTLHL---TRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELV 574
            ::.|.|..|.|.:|......|..:...|   |.|||.....|                       
  Rat   322 LAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPH----------------------- 363

  Fly   575 LSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQI-NNRLRTIYMDKNGVTLQ 638
                        |.:.|..|:||.:|.:|.|.:||.|...|.|||.. :..||.:::....||..
  Rat   364 ------------FCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDS 416

  Fly   639 GYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNC 689
            |.:.:...|..|.|:|.:         .|.::......|::.::.|.|.:|
  Rat   417 GCSSLATVLLANRSLREL---------DLSNNCMGDTGVLQLLESLKQPSC 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRNP_001260788.1 LRR_RI 198..516 CDD:238064 80/327 (24%)
leucine-rich repeat 289..331 CDD:275381 10/41 (24%)
leucine-rich repeat 332..352 CDD:275381 7/19 (37%)
leucine-rich repeat 364..389 CDD:275380 8/25 (32%)
leucine-rich repeat 391..417 CDD:275380 7/27 (26%)
leucine-rich repeat 418..449 CDD:275380 6/30 (20%)
LRR_RI 441..>656 CDD:238064 62/250 (25%)
leucine-rich repeat 450..467 CDD:275380 3/16 (19%)
leucine-rich repeat 468..503 CDD:275380 16/60 (27%)
leucine-rich repeat 508..534 CDD:275380 7/31 (23%)
leucine-rich repeat 535..564 CDD:275380 6/31 (19%)
leucine-rich repeat 570..596 CDD:275380 3/25 (12%)
leucine-rich repeat 597..618 CDD:275380 8/20 (40%)
CARMIL_C 797..1108 CDD:292619
Rnh1NP_001257691.1 LRR_RI 37..356 CDD:238064 84/345 (24%)
leucine-rich repeat 38..60 CDD:275380 6/21 (29%)
LRR <46..361 CDD:227223 86/341 (25%)
leucine-rich repeat 61..88 CDD:275380 2/26 (8%)
leucine-rich repeat 89..113 CDD:275380 8/33 (24%)
leucine-rich repeat 118..145 CDD:275380 10/34 (29%)
leucine-rich repeat 146..174 CDD:275380 9/27 (33%)
leucine-rich repeat 175..202 CDD:275380 7/27 (26%)
leucine-rich repeat 203..231 CDD:275380 6/30 (20%)
leucine-rich repeat 232..259 CDD:275380 7/31 (23%)
leucine-rich repeat 260..288 CDD:275380 10/27 (37%)
leucine-rich repeat 289..309 CDD:275380 2/19 (11%)
leucine-rich repeat 317..336 CDD:275380 5/18 (28%)
LRR_RI 318..>465 CDD:238064 42/185 (23%)
leucine-rich repeat 374..402 CDD:275380 11/27 (41%)
leucine-rich repeat 403..430 CDD:275380 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166336034
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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