Protein Alignment LRR and Rnh1

DIOPT Version :10

• Sequence 1: NP_001260788.1
• Gene: LRR / 35715
• FlyBaseID: FBgn0033212
• Length: 1486
• Species: Drosophila melanogaster
• Sequence 2: NP_001257691.1
• Gene: Rnh1 / 100360501
• RGDID: 621398
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 506
• Identity: 121/506 - (23%)
• Similarity: 178/506 - (35%)
• Gaps: 142/506 - (28%)

  Fly   255 RSMWLEELH----------LEALG-LRWDFLNKL--------------------SISVITNSNPA 288
            :|:|...||          .|.|. .||..|..|                    .|.....:|||
  Rat    24 QSVWTRRLHCAPTMSLDIQCEQLSDARWTELLPLIQQYQVVRLDDCGLTEVRCKDIRSAIQANPA 88

  Fly   289 IRTIDLSHNIIEDKGASSLCALFGKIVQGAIHLAGPIAKVSKGLCKLALAHCGLTSKGVNQMSHS 353
            :..:.|..|.:.|.|.       |.::||   |..|..|:.    ||:|.:|.||..|...:...
  Rat    89 LTELSLRTNELGDAGV-------GLVLQG---LQNPTCKIQ----KLSLQNCSLTEAGCGVLPDV 139

  Fly   354 LTLNQSISNSLTYLDLSGNSLKDD-ITNLHNFLAQPNV-LEHLDLASTDITLENL--FGALLRGC 414
            |   :|:| :|..|.|:.|.|.|: :..|...|..|.. ||.|.|...::|..:.  ..::|| .
  Rat   140 L---RSLS-TLRELHLNDNPLGDEGLKLLCEGLRDPQCRLEKLQLEYCNLTATSCEPLASVLR-V 199

  Fly   415 ATHLAHLNVSHNSFSTKKGKEIPPSFKQFFTSTFSLKHLNIAGCKLPMEALKNLLLGLACN--ES 477
            ......|.:|:|.|.......:....|.   |...|:.|.:..|.:.....|:|     |:  .|
  Rat   200 KPDFKELVLSNNDFHEAGIHTLCQGLKD---SACQLESLKLENCGITSANCKDL-----CDVVAS 256

  Fly   478 TAGLY-LDLSSNTLGAQGAHVL-----------------------ESCIHGVRVLQS------LD 512
            .|.|. |||.||.||..|...|                       |.|....|||::      |.
  Rat   257 KASLQELDLGSNKLGNTGIAALCSGLLLPSCRLRTLWLWDCDVTAEGCKDLCRVLRAKQSLKELS 321

  Fly   513 ISDNNLDAELAPVLTAISKNPSIRTLHL---TRSLTGMKPKHIPPVMDALVNLIQKDDFPLVELV 574
            ::.|.|..|.|.:|......|..:...|   |.|||.....|
  Rat   322 LAGNELKDEGAQLLCESLLEPGCQLESLWVKTCSLTAASCPH----------------------- 363

  Fly   575 LSENKLKHDLHDFINALGSNQSLQKLDISGNFMGDVGARLLAKALQI-NNRLRTIYMDKNGVTLQ 638
                        |.:.|..|:||.:|.:|.|.:||.|...|.|||.. :..||.:::....||..
  Rat   364 ------------FCSVLTKNRSLFELQMSSNPLGDSGVVELCKALGYPDTVLRVLWLGDCDVTDS 416

  Fly   639 GYADIVYALEHNHSMRTIPFPVFDIAPHLKSHPDKTDAVMRKMQELLQRNC 689
            |.:.:...|..|.|:|.:         .|.::......|::.::.|.|.:|
  Rat   417 GCSSLATVLLANRSLREL---------DLSNNCMGDTGVLQLLESLKQPSC 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRR	NP_001260788.1	Carm_PH	25..130	CDD:436119
		RNA1	<198..402	CDD:444072	47/179 (26%)
		leucine-rich repeat	289..331	CDD:275381	10/41 (24%)
		leucine-rich repeat	332..352	CDD:275381	7/19 (37%)
		RNA1	<335..653	CDD:444072	89/357 (25%)
		leucine-rich repeat	364..389	CDD:275380	8/25 (32%)
		leucine-rich repeat	391..417	CDD:275380	7/27 (26%)
		leucine-rich repeat	418..449	CDD:275380	6/30 (20%)
		leucine-rich repeat	450..467	CDD:275380	3/16 (19%)
		leucine-rich repeat	468..503	CDD:275380	16/60 (27%)
		leucine-rich repeat	508..534	CDD:275380	7/31 (23%)
		leucine-rich repeat	535..564	CDD:275380	6/31 (19%)
		leucine-rich repeat	570..596	CDD:275380	3/25 (12%)
		leucine-rich repeat	597..618	CDD:275380	8/20 (40%)
		CARMIL_C	797..1111	CDD:464966
Rnh1	NP_001257691.1	LRR_RI	37..356	CDD:238064	84/345 (24%)
		leucine-rich repeat	38..60	CDD:275380	6/21 (29%)
		leucine-rich repeat	61..88	CDD:275380	2/26 (8%)
		leucine-rich repeat	89..113	CDD:275380	8/33 (24%)
		leucine-rich repeat	118..145	CDD:275380	10/34 (29%)
		leucine-rich repeat	146..174	CDD:275380	9/27 (33%)
		leucine-rich repeat	175..202	CDD:275380	7/27 (26%)
		leucine-rich repeat	203..231	CDD:275380	6/30 (20%)
		leucine-rich repeat	232..259	CDD:275380	7/31 (23%)
		leucine-rich repeat	260..288	CDD:275380	10/27 (37%)
		leucine-rich repeat	289..309	CDD:275380	2/19 (11%)
		RNA1	<313..>455	CDD:444072	40/185 (22%)
		leucine-rich repeat	317..336	CDD:275380	5/18 (28%)
		leucine-rich repeat	374..402	CDD:275380	11/27 (41%)
		leucine-rich repeat	403..430	CDD:275380	7/26 (27%)