Protein Alignment U2A and LRMDA

DIOPT Version :10

• Sequence 1: NP_610315.1
• Gene: U2A / 35713
• FlyBaseID: FBgn0033210
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_001292510.1
• Gene: LRMDA / 83938
• HGNCID: 23405
• Length: 226
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 66/233 - (28%)
• Similarity: 94/233 - (40%)
• Gaps: 67/233 - (28%)

  Fly    13 MQYI-NPCRERELDLRGYKIPQIENLGATLDQF-DTIDLSDNDLRK--------------LDN-- 59
            :.|| ..|||         ||  |:||.....| ..:|||.|.||.              |||
Human    11 VSYIGQDCRE---------IP--EHLGRDCGHFAKRLDLSFNLLRSLEGLSAFRSLEELILDNNQ 64

  Fly    60 ------LPHLPRLKCLLLNNNRIL---RISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKL 115
                  ||.||||..|.||.|||.   .:.:.|.|..|.|..:.|.||    ::....||...|.
Human    65 LGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVTPALEYLSLLGN----VACPNELVSLEKD 125

  Fly   116 ETICLLINPVSTKPNYREYMAYKFPQLRLLDFRKIKQKDRQAA---QEFFRTKQGKDVLKEISRK 177
            |         .....||.::.||.|.|:.||.:|:.:::|:.|   ..|.:..:.|...::::..
Human   126 E---------EDYKRYRCFVLYKLPNLKFLDAQKVTRQEREEALVRGVFMKVVKPKASSEDVASS 181

  Fly   178 SKM------SAAAAIAAEAG-NGK------GRGSEGGR 202
            .:.      ||:..:.:..| .||      |:.|||.|
Human   182 PERHYTPLPSASRELTSHQGVLGKCRYVYYGKNSEGNR 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2A	NP_610315.1	LRR_9	1..175	CDD:405295	56/191 (29%)
		leucine-rich repeat	22..43	CDD:275380	5/20 (25%)
		leucine-rich repeat	46..65	CDD:275378	12/40 (30%)
		leucine-rich repeat	66..89	CDD:275378	9/25 (36%)
		leucine-rich repeat	90..114	CDD:275378	6/23 (26%)
LRMDA	NP_001292510.1	leucine-rich repeat	34..54	CDD:275378	6/19 (32%)
		LRR_9	<36..159	CDD:405295	42/135 (31%)
		leucine-rich repeat	55..76	CDD:275378	6/20 (30%)
		leucine-rich repeat	77..103	CDD:275378	9/25 (36%)
		leucine-rich repeat	104..142	CDD:275378	12/50 (24%)