DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment U2A and LRMDA

DIOPT Version :9

Sequence 1:NP_610315.1 Gene:U2A / 35713 FlyBaseID:FBgn0033210 Length:265 Species:Drosophila melanogaster
Sequence 2:NP_001292510.1 Gene:LRMDA / 83938 HGNCID:23405 Length:226 Species:Homo sapiens


Alignment Length:233 Identity:66/233 - (28%)
Similarity:94/233 - (40%) Gaps:67/233 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 MQYI-NPCRERELDLRGYKIPQIENLGATLDQF-DTIDLSDNDLRK--------------LDN-- 59
            :.|| ..|||         ||  |:||.....| ..:|||.|.||.              |||  
Human    11 VSYIGQDCRE---------IP--EHLGRDCGHFAKRLDLSFNLLRSLEGLSAFRSLEELILDNNQ 64

  Fly    60 ------LPHLPRLKCLLLNNNRIL---RISEGLEEAVPNLGSIILTGNNLQELSDLEPLVGFTKL 115
                  ||.||||..|.||.|||.   .:.:.|.|..|.|..:.|.||    ::....||...|.
Human    65 LGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVTPALEYLSLLGN----VACPNELVSLEKD 125

  Fly   116 ETICLLINPVSTKPNYREYMAYKFPQLRLLDFRKIKQKDRQAA---QEFFRTKQGKDVLKEISRK 177
            |         .....||.::.||.|.|:.||.:|:.:::|:.|   ..|.:..:.|...::::..
Human   126 E---------EDYKRYRCFVLYKLPNLKFLDAQKVTRQEREEALVRGVFMKVVKPKASSEDVASS 181

  Fly   178 SKM------SAAAAIAAEAG-NGK------GRGSEGGR 202
            .:.      ||:..:.:..| .||      |:.|||.|
Human   182 PERHYTPLPSASRELTSHQGVLGKCRYVYYGKNSEGNR 219

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U2ANP_610315.1 LRR_9 1..175 CDD:258718 56/191 (29%)
leucine-rich repeat 22..43 CDD:275380 5/20 (25%)
LRR_4 46..81 CDD:289563 21/59 (36%)
leucine-rich repeat 46..65 CDD:275378 12/40 (30%)
leucine-rich repeat 66..89 CDD:275378 9/25 (36%)
leucine-rich repeat 90..114 CDD:275378 6/23 (26%)
LRMDANP_001292510.1 LRR_RI <27..>113 CDD:238064 29/89 (33%)
leucine-rich repeat 34..54 CDD:275378 6/19 (32%)
LRR_8 53..112 CDD:290566 20/58 (34%)
LRR_4 54..93 CDD:289563 15/38 (39%)
leucine-rich repeat 55..76 CDD:275378 6/20 (30%)
leucine-rich repeat 77..103 CDD:275378 9/25 (36%)
leucine-rich repeat 104..142 CDD:275378 12/50 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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