Protein Alignment U2A and Cntrl

DIOPT Version :10

• Sequence 1: NP_610315.1
• Gene: U2A / 35713
• FlyBaseID: FBgn0033210
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_001366203.1
• Gene: Cntrl / 26920
• MGIID: 1889576
• Length: 2334
• Species: Mus musculus
• Alignment Length: 281
• Identity: 74/281 - (26%)
• Similarity: 117/281 - (41%)
• Gaps: 60/281 - (21%)

  Fly     4 LTPELINQSMQYINPCRERELDLR-----GYKIPQIENLGATLDQFDTIDLSDNDLRKLDNLPHL 63
            :|..||.:..:..|....:.|:|.     |.|...||||...: :.:.::||.|.:.|::.:..|
Mouse    83 ITEALIKKLTKQDNLALVKSLNLSLSKDGGKKFRYIENLEKCV-KLEVLNLSYNLIVKIEKVDKL 146

  Fly    64 PRLKCLLLNNNRILRISEGLEEAVPNLGSIILTGN---------------------------NLQ 101
            .||:.|.|:.|:|.:| ||||. :.||..:.|.||                           :||
Mouse   147 LRLRELNLSYNKISKI-EGLEN-MCNLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNKISSLQ 209

  Fly   102 ELSDLEPLVGFTKLETICLLINPVSTKPNYREYMAYKFPQLRLLDFRKIKQKDRQAAQEFFRTKQ 166
            ::|.|:||...|.|   .|:.|||...|:|.:::.:....|..|:.:.:..:|||.|.|.|.
Mouse   210 DVSKLKPLQDLTSL---VLIDNPVVALPHYLQFIIFHLRSLESLEGQPVTTQDRQEAFERFS--- 268

  Fly   167 GKDVLKEISRKSKMSAAAAIAAEAGNGKGRGSEGGRLANPQD--MQRIREAIKRASSLAEVERLS 229
                |:||.|..|......:..|            .|.|.|.  ::.|:...|...||.| |.:.
Mouse   269 ----LEEIERLEKDLEKKTVETE------------ELKNKQTKFLEEIKNQDKLNKSLKE-EAML 316

  Fly   230 QILQSGQLPDKFQHEMEAVAQ 250
            |.....:|......:.|.:.|
Mouse   317 QKQSCEELESDLSTKKELLKQ 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2A	NP_610315.1	LRR_9	1..175	CDD:405295	57/202 (28%)
		leucine-rich repeat	22..43	CDD:275380	8/25 (32%)
		leucine-rich repeat	46..65	CDD:275378	5/18 (28%)
		leucine-rich repeat	66..89	CDD:275378	10/22 (45%)
		leucine-rich repeat	90..114	CDD:275378	10/50 (20%)
Cntrl	NP_001366203.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70
		PPP1R42	89..261	CDD:455733	47/177 (27%)
		leucine-rich repeat	100..119	CDD:275378	4/18 (22%)
		LRR 1	126..147		4/20 (20%)
		leucine-rich repeat	127..148	CDD:275380	5/20 (25%)
		LRR 2	148..169		11/22 (50%)
		leucine-rich repeat	149..170	CDD:275380	10/22 (45%)
		LRR 3	170..191		5/20 (25%)
		leucine-rich repeat	171..194	CDD:275380	4/22 (18%)
		LRR 4	194..215		3/20 (15%)
		leucine-rich repeat	195..219	CDD:275380	6/23 (26%)
		leucine-rich repeat	220..246	CDD:275380	8/28 (29%)
		Smc	441..>1097	CDD:440809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..562
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	751..771
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1154..1198
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1213..1245
		Drf_FH1	<1239..1310	CDD:461881
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1338..1360
		SMC_prok_B	1407..2216	CDD:274008
		Required for centrosome localization. /evidence=ECO:0000250	1951..2121
		Sufficient for interaction with HOOK2. /evidence=ECO:0000250	1988..2334
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2291..2334