Protein Alignment Rdh1 and CBR1

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_001748.1
• Gene: CBR1 / 873
• HGNCID: 1548
• Length: 277
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 78/291 - (26%)
• Similarity: 122/291 - (41%)
• Gaps: 67/291 - (23%)

  Fly    45 VFIVTGANTGIGKETALEIARR-GGTVYLACRDMNRCEKARKDIIKETNNQNIFSR--ELDLSSL 106
            |.:|||.|.|||.....::.|. .|.|.|..||:.|.:.|    :::...:.:..|  :||:..|
Human     7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAA----VQQLQAEGLSPRFHQLDIDDL 67

  Fly   107 DSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYELQLGV----NHIGHFLLTNLLLDVLK 167
            .|||...|..:||...|.||:||||:  ..|......:.:|..|    |..|...:...||.::|
Human    68 QSIRALRDFLRKEYGGLDVLVNNAGI--AFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIK 130

  Fly   168 NSAPSRIVVVSSLAHAR------------------------GSIN--VADLNSEKSYDEG---LA 203
              ...|:|.|||:...|                        |.:|  |.|........||   .|
Human   131 --PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSA 193

  Fly   204 YSQSKLA----NVLFTRELAKRLEGSGVTVNALHPGVVDTELARNWAFFQTNLVKFFLKPMIWPL 264
            |..:|:.    :.:..|:|:::.:|..:.:||..||.|.|::|...|
Human   194 YGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA------------------ 240

  Fly   265 LKTPKSGAQTSIY-AALDPELKNISGLYFSD 294
            .|:|:.||:|.:| |.|.|:.:...|.:.|:
Human   241 TKSPEEGAETPVYLALLPPDAEGPHGQFVSE 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	78/291 (27%)
CBR1	NP_001748.1	carb_red_PTCR-like_SDR_c	6..277	CDD:187585	78/291 (27%)