Protein Alignment Rdh1 and HSD17B6

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_003716.2
• Gene: HSD17B6 / 8630
• HGNCID: 23316
• Length: 317
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 69/290 - (23%)
• Similarity: 123/290 - (42%)
• Gaps: 62/290 - (21%)

  Fly    21 VGIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARK 85
            ||:|:|..:.:..:......:  |...:||.::|.|...|.::..||..|..||    ..||..:
Human     9 VGLYYLLHWYRERQVVSHLQD--KYVFITGCDSGFGNLLARQLDARGLRVLAAC----LTEKGAE 67

  Fly    86 DIIKETNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHV-------LINNAGVMRCPKTL---- 139
            .:..:|::: :.:..||::.::||.......|:     ||       |:||||:: .|.||
Human    68 QLRGQTSDR-LETVTLDVTKMESIAAATQWVKE-----HVGDRGLWGLVNNAGIL-TPITLCEWL 125

  Fly   140 -TKDGYELQLGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLAHARGSI-NVADLNSEKSYDEGL 202
             |:|...: |.||.||...:|..:|.:::              .|||.| ||:.:....::..|
Human   126 NTEDSMNM-LKVNLIGVIQVTLSMLPLVR--------------RARGRIVNVSSILGRVAFFVG- 174

  Fly   203 AYSQSKLANVLFTRELAKRLEGSGVTVNALHPGVVDTELARNWAFFQTNLVKF--FLKPMIWPLL 265
            .|..||.....|:..|.:.::..||.::.:.||           :|:|.:...  .|:.|.....
Human   175 GYCVSKYGVEAFSDILRREIQHFGVKISIVEPG-----------YFRTGMTNMTQSLERMKQSWK 228

  Fly   266 KTPKSGAQT-------SIYAALDPELKNIS 288
            :.||...:|       ::|..:...|.|.|
Human   229 EAPKHIKETYGQQYFDALYNIMKEGLLNCS 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	65/268 (24%)
HSD17B6	NP_003716.2	type2_17beta_HSD-like_SDR_c	30..306	CDD:187665	65/267 (24%)