Protein Alignment Rdh1 and BDH1

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: XP_011511369.1
• Gene: BDH1 / 622
• HGNCID: 1027
• Length: 347
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 59/283 - (20%)
• Similarity: 107/283 - (37%)
• Gaps: 70/283 - (24%)

  Fly    44 KVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELDLSSLDS 108
            |..:|||.::|.|...|..:..:|..|:..|...::.....|: :...|:..:.:.:|::.|.:.
Human    60 KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKE-LDSLNSDRLRTVQLNVCSSEE 123

  Fly   109 IRKFVD----GFKKEQPKLHVLINNAGVMRCPKT--LTKDGYELQLGVNHIGHFLLTNLLLDVLK 167
            :.|.|:    ..|..:..:..|:||||:....:.  .:.:.|:....||..|...:|...|.:::
Human   124 VEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIR 188

  Fly   168 NSAPSRIVVVSSLA-----HARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGV 227
            . |..|:|.:||:.     .||....:.....| ::.:.|.|....|                ||
Human   189 R-AKGRVVNISSMLGRMANPARSPYCITKFGVE-AFSDCLRYEMYPL----------------GV 235

  Fly   228 TVNALHPG--VVDTELARNWAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYAALDPEL--KNIS 288
            .|:.:.||  :..|.|      :....::...|.| |..|                ||:  |:..
Human   236 KVSVVEPGNFIAATSL------YSPESIQAIAKKM-WEEL----------------PEVVRKDYG 277

  Fly   289 GLYFSDCKPKPVASGALDDKVAK 311
            ..||             |:|:||
Human   278 KKYF-------------DEKIAK 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	59/283 (21%)
BDH1	XP_011511369.1	type2_17beta_HSD-like_SDR_c	60..345	CDD:187665	59/283 (21%)