DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG2064 and WWOX

DIOPT Version :9

Sequence 1:NP_610310.2 Gene:CG2064 / 35708 FlyBaseID:FBgn0033205 Length:330 Species:Drosophila melanogaster
Sequence 2:NP_057457.1 Gene:WWOX / 51741 HGNCID:12799 Length:414 Species:Homo sapiens


Alignment Length:304 Identity:125/304 - (41%)
Similarity:178/304 - (58%) Gaps:27/304 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 EYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETN 92
            |.:||..|      ||||.:|||||:|||.|||...|..|..|.||||:|.|..:|...|::|.:
Human   115 EILQGRDF------TGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWH 173

  Fly    93 NQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYELQLGVNHIGHFL 157
            ...:.:..|||:.|.|::.|.:.||.:...||||:.||.....|.:|||||.|....|||:|||.
Human   174 KAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFY 238

  Fly   158 LTNLLLDVLKNSAPSRIVVVSSLAH-------ARGSINVADLNSEKS-YDEGLAYSQSKLANVLF 214
            |..||.|||..|||:|::||||.:|       :.|.::.:.|:..|: |...|||::|||.|:||
Human   239 LVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILF 303

  Fly   215 TRELAKRLEGSGVTVNALHPG-VVDTELARNWAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYA 278
            :.||.:||...|||.||:||| ::.:.:.|:|      .|...|..:..|..|:.:.||.|::|.
Human   304 SNELHRRLSPRGVTSNAVHPGNMMYSNIHRSW------WVYTLLFTLARPFTKSMQQGAATTVYC 362

  Fly   279 ALDPELKNISGLYFSD---CKPKPVASGALDDKVAKFLWAESEK 319
            |..|||:.:.|:||::   |.|.|.|.   .::.|:.|||.||:
Human   363 AAVPELEGLGGMYFNNCCRCMPSPEAQ---SEETARTLWALSER 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2064NP_610310.2 PRK06197 40..322 CDD:235737 121/292 (41%)
NADB_Rossmann 43..317 CDD:304358 118/285 (41%)
WWOXNP_057457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WW 19..47 CDD:238122
Nuclear localization signal. /evidence=ECO:0000250 50..55
WW 60..90 CDD:238122
human_WWOX_like_SDR_c-like 124..407 CDD:187669 120/289 (42%)
Interaction with MAPT. /evidence=ECO:0000250 125..414 119/288 (41%)
Mediates targeting to the mitochondria. /evidence=ECO:0000250 209..273 30/63 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1208
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000061
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100091
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X72
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.710

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