Protein Alignment Rdh1 and HSD17B11

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_057329.3
• Gene: HSD17B11 / 51170
• HGNCID: 22960
• Length: 300
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 81/301 - (26%)
• Similarity: 121/301 - (40%)
• Gaps: 89/301 - (29%)

  Fly     8 LLSPLIMWPATIGVGI-YFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVY 71
            ||..|::.|..|...: .|:|.::.  |..|..  ||::.::|||..|||:.||.|.|:....:.
Human     4 LLDILLLLPLLIVCSLESFVKLFIP--KRRKSV--TGEIVLITGAGHGIGRLTAYEFAKLKSKLV 64

  Fly    72 LACRDMN---------RCE----KARKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKL 123
            |  .|:|         :|:    |....::..:|.::|:|         |.:|    .|.|...:
Human    65 L--WDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYS---------SAKK----VKAEIGDV 114

  Fly   124 HVLINNAGVMRCPKTLTKDGYELQ-------LGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLA 181
            .:|:|||||:     .|.|.:..|       ..||.:.||..|...|..:..:....||.|:|
Human   115 SILVNNAGVV-----YTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVAS-- 172

  Fly   182 HARGSINVADLNSEKSYDEGLAYSQSKLANVLF----TRELAKRLEGSGVTVNALHPGVVDTELA 242
             |.|.::|..|         |||..||.|.|.|    |.||| .|:.:||....|.|..|:|...
Human   173 -AAGHVSVPFL---------LAYCSSKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVNTGFI 226

  Fly   243 RNWAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYAALDPE 283
            :|                           ..||:...|:||
Human   227 KN---------------------------PSTSLGPTLEPE 240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	71/265 (27%)
HSD17B11	NP_057329.3	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	70/263 (27%)