Protein Alignment Rdh1 and HSD17B13

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_835236.2
• Gene: HSD17B13 / 345275
• HGNCID: 18685
• Length: 300
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 59/232 - (25%)
• Similarity: 103/232 - (44%)
• Gaps: 35/232 - (15%)

  Fly    43 GKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRE--LDLSS 105
            |::.::|||..|||::|..|.|:|...:.|  .|:|:  :..::...|.....:.:..  :|.|:
Human    36 GEIVLITGAGHGIGRQTTYEFAKRQSILVL--WDINK--RGVEETAAECRKLGVTAHAYVVDCSN 96

  Fly   106 LDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYEL--QLGVNHIGHFLLTNLLLDVLKN 168
            .:.|.:.::..|||...:.:::||||.:.....|:....|:  ...||.:|||.:|..||..:..
Human    97 REEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMME 161

  Fly   169 SAPSRIVVVSSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEG---SGVTVN 230
            .....||.|:|:....|...:            :.|..||.|.|.|.|.|...|:.   :|:..:
Human   162 RNHGHIVTVASVCGHEGIPYL------------IPYCSSKFAAVGFHRGLTSELQALGKTGIKTS 214

  Fly   231 ALHPGVVDTELARNWAFFQTNLVKFFLKPMIWPLLKT 267
            .|.|..|:|...:|            ....:||:|:|
Human   215 CLCPVFVNTGFTKN------------PSTRLWPVLET 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	59/232 (25%)
HSD17B13	NP_835236.2	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	58/230 (25%)