Protein Alignment Rdh1 and HSD17B2

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_002144.1
• Gene: HSD17B2 / 3294
• HGNCID: 5211
• Length: 387
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 64/255 - (25%)
• Similarity: 108/255 - (42%)
• Gaps: 41/255 - (16%)

  Fly     1 MCIFIDCLLSP---LIMWPATIGVGIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALE 62
            :|.....:|||   ||::    .|..:.:..|:.|.:.. ..|:  |..:|||.:.|:|......
Human    44 LCAVCLLILSPFWGLILF----SVSCFLMYTYLSGQELL-PVDQ--KAVLVTGGDCGLGHALCKY 101

  Fly    63 IARRGGTVYLACRDMN--RCEKARKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKK-----EQ 120
            :...|.||:....:.|  ..|:.|:     |.:..:...::|::....|:   |.:.|     :.
Human   102 LDELGFTVFAGVLNENGPGAEELRR-----TCSPRLSVLQMDITKPVQIK---DAYSKVAAMLQD 158

  Fly   121 PKLHVLINNAGVMRCP---KTLTKDGYELQLGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLAH 182
            ..|..:||||||:..|   :.|....|:..:.||..|...:|...|.:|:.| ..|:|.|||:.
Human   159 RGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKS-KGRLVNVSSMG- 221

  Fly   183 ARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGVTVNALHPGVVDTELA 242
              |...:..|.|         |..||.|..:|:..:...|...|:.|.::.||...|.:|
Human   222 --GGAPMERLAS---------YGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIA 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	54/210 (26%)
HSD17B2	NP_002144.1	type2_17beta_HSD-like_SDR_c	83..362	CDD:187665	54/209 (26%)