Protein Alignment Rdh1 and HSD11B2

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_000187.3
• Gene: HSD11B2 / 3291
• HGNCID: 5209
• Length: 405
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 88/369 - (23%)
• Similarity: 129/369 - (34%)
• Gaps: 103/369 - (27%)

  Fly     5 IDCLLSPLIMWPATIGV----GIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIAR 65
            :|.|...|:..||.:.|    |...|....:..:....|    :..::||.::|.|||||.::..
Human    44 LDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVAT----RAVLITGCDSGFGKETAKKLDS 104

  Fly    66 RGGTVYLACRDMN--------RCEKARKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKKEQPK 122
            .|.||.....::|        .|...|..::           ::||:....|.:.:     |..|
Human   105 MGFTVLATVLELNSPGAIELRTCCSPRLRLL-----------QMDLTKPGDISRVL-----EFTK 153

  Fly   123 LHV-------LINNAG---VMRCPKTLTKDGYELQLGVNHIGHFLLTNLLLDVLKNSAPSRIVVV 177
            .|.       |:||||   |:...:......:...:.||..|...||..||.:|::|. .|||.|
Human   154 AHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSR-GRIVTV 217

  Fly   178 SSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGVTVNALHPGVVDTELA 242
            .|.|   |.:....|.         ||..||.|..|.....:..|...||.|:.:.||...||..
Human   218 GSPA---GDMPYPCLG---------AYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESV 270

  Fly   243 RN---W--------AFFQTNLVKFFLKPMIWPL-------LK------TPKSGAQTSIYAALDPE 283
            ||   |        |.....|::.:.|..|..|       |:      ||...|.|....|..|.
Human   271 RNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPR 335

  Fly   284 LKNISG-----LYF-------------------SDCKPKPVASG 303
            .:...|     :||                   |.|.|:.:..|
Human   336 RRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPG 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	79/327 (24%)
HSD11B2	NP_000187.3	type2_17beta_HSD-like_SDR_c	83..363	CDD:187665	75/308 (24%)
		Essential for protein stability	335..339		0/3 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..405		1/3 (33%)