Protein Alignment Rdh1 and Hsd17b13

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_001009684.1
• Gene: Hsd17b13 / 305150
• RGDID: 1359553
• Length: 300
• Species: Rattus norvegicus
• Alignment Length: 303
• Identity: 78/303 - (25%)
• Similarity: 123/303 - (40%)
• Gaps: 52/303 - (17%)

  Fly     1 MCIFIDCLLSPLIMWPATIGVGIYFLKEYMQGGKF---TKDTDETGKVFIVTGANTGIGKETALE 62
            |.:.::.||        .:|:.||...|.:.  ||   .:.....|:..::|||..|||:.||.|
  Rat     1 MNLILELLL--------LVGIIIYSYLESLV--KFFIPQRRKSVAGQTVLITGAGHGIGRLTAYE 55

  Fly    63 IARRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLI 127
            .|::...:.|.....:..|:......|.....::|  .:|.|:...|.|.||..|||...:.:::
  Rat    56 FAKQKSRLVLWDISKHGVEETAAKCRKLGAVVHVF--VVDCSNRAEIYKSVDQVKKEVGDIEIVV 118

  Fly   128 NNAGVMRCPKTLTKDGYEL--QLGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLAHARGSINVA 190
            ||||.:.....|:....|:  ...||.:|||.:...||..:.......||.|:|:.   |...:.
  Rat   119 NNAGAIYPADLLSTKDEEITKTFEVNILGHFWIIKALLPSMLRRNSGHIVTVASVC---GHRVIP 180

  Fly   191 DLNSEKSYDEGLAYSQSKLANVLFTRELAKRLE---GSGVTVNALHPGVVDTELARNWAFFQTNL 252
            .|         :.|..||.|.|.|.|.|...|:   .:|:..:.|.|..|:|...:|
  Rat   181 YL---------IPYCSSKFAAVGFHRALTAELDTLGKTGIKTSCLCPVFVNTGFTKN-------- 228

  Fly   253 VKFFLKPMIWPLLKTPKSGAQTSIYAALD-------PELKNIS 288
                ....:||:|: |...|::.|...|.       |...|||
  Rat   229 ----PSTRLWPVLE-PDEVARSLIDGILTNKKMIFVPSYINIS 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	69/258 (27%)
Hsd17b13	NP_001009684.1	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	68/256 (27%)