Protein Alignment Rdh1 and Hsd17b11

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_001004209.1
• Gene: Hsd17b11 / 289456
• RGDID: 1303235
• Length: 298
• Species: Rattus norvegicus
• Alignment Length: 261
• Identity: 71/261 - (27%)
• Similarity: 110/261 - (42%)
• Gaps: 47/261 - (18%)

  Fly     8 LLSPLIMWPATIGVGIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYL 72
            ||..:::.|..|   ::.::.:::.....|.....|::.::|||..|||:.||.|.|:.  ...|
  Rat     4 LLDLILLLPLLI---VFCIESFIKRLIPKKKKSVAGEIVLITGAGHGIGRLTAYEFAKL--NTKL 63

  Fly    73 ACRDMNRCEKARKDIIKETN------NQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLINNAG 131
            ...|:|      |:.|:||.      ...:....:|.|..:.|...|...|:|...:.:|:||||
  Rat    64 VLWDIN------KNGIEETAAKCRKLGAQVHPFVVDCSQREEIYSAVRKVKEEVGDVSILVNNAG 122

  Fly   132 VMRCPKTLTKDGYELQ-------LGVNHIGHFLLTNLLLDVLKNSAPSRIVVVSSLAHARGSINV 189
            |:     .|.|.:..|       ..||.:.||..|...|..:..:....:|.|:|   |.|...|
  Rat   123 VV-----YTADLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMMKNNHGHVVTVAS---AAGHTVV 179

  Fly   190 ADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEG---SGVTVNALHPGVVDTELARNWAFFQTN 251
            ..|         |||..||.|.|.|.|.|...|..   :||..:.|.|..::|...:|.:   ||
  Rat   180 PFL---------LAYCSSKFAAVGFHRALTDELAALGCTGVRTSCLCPNFINTGFIKNPS---TN 232

  Fly   252 L 252
            |
  Rat   233 L 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	66/226 (29%)
Hsd17b11	NP_001004209.1	17beta-HSDXI-like_SDR_c	38..277	CDD:187598	65/224 (29%)