Protein Alignment Rdh1 and RDH10

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_742034.1
• Gene: RDH10 / 157506
• HGNCID: 19975
• Length: 341
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 67/285 - (23%)
• Similarity: 111/285 - (38%)
• Gaps: 64/285 - (22%)

  Fly    13 IMWPATIGVGIYFLKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARR----------- 66
            ::|...:....:.::        .|:....|:|.::|||.:|:|:..|||.|||
Human    14 VLWAFVLAAARWLVR--------PKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINT 70

  Fly    67 ------GGTVYLACRDMNRCEKA-------RKDIIKETNNQNIFSRELDLSSLDSIRKFVDGFKK 118
                  .|.|....||:...:.|       .::|:...|.| :|:...|:...:::....:..:|
Human    71 QSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQ-VFTYTCDVGKRENVYLTAERVRK 134

  Fly   119 EQPKLHVLINNAGV------MRCPKTLTKDGYELQLGVNHIGHFLLTNLLLDVLKNSAPSRIVVV 177
            |..::.||:|||||      :.||..|    .|..:.||...||..|...|..:.......||.|
Human   135 EVGEVSVLVNNAGVVSGHHLLECPDEL----IERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTV 195

  Fly   178 SSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELA---KRLEGSGVTVNALHPGVVDT 239
            :|......:..|.|            |..||...|.|...|:   |..|..|:....:.|.:|||
Human   196 ASSLGLFSTAGVED------------YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDT 248

  Fly   240 ELARNWAFFQTNLVKFFLKPMIWPL 264
                  ..|:...::..::|.:.||
Human   249 ------GMFRGCRIRKEIEPFLPPL 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	65/255 (25%)
RDH10	NP_742034.1	17beta-HSDXI-like_SDR_c	38..307	CDD:187598	64/253 (25%)