Protein Alignment Rdh1 and Hsd17b1

DIOPT Version :10

• Sequence 1: NP_610310.2
• Gene: Rdh1 / 35708
• FlyBaseID: FBgn0033205
• Length: 330
• Species: Drosophila melanogaster
• Sequence 2: NP_034605.1
• Gene: Hsd17b1 / 15485
• MGIID: 105077
• Length: 344
• Species: Mus musculus
• Alignment Length: 287
• Identity: 65/287 - (22%)
• Similarity: 112/287 - (39%)
• Gaps: 74/287 - (25%)

  Fly    45 VFIVTGANTGIGKETALEIA---RRGGTVYLACRDMNRCEKARKDIIKETNNQNIFSRELDLSSL 106
            |.::||.::|||...|:.:|   .:...||...||:    ||:..:::....|......|::..|
Mouse     5 VVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDL----KAQGPLLEAARTQGCPPGSLEILEL 65

  Fly   107 DSIR--KFVDGFKK--EQPKLHVLINNAGVMRCPKTL--TKDGYELQ-----LGVNHIGHFLLTN 160
            | :|  |.|...:.  .:.::.||:.|||     :.|  ..:.:||.     |.||.:|...:..
Mouse    66 D-VRDSKSVAAAQACVTEGRVDVLVCNAG-----RGLFGPLEAHELNAVGAVLDVNVLGTIRMLQ 124

  Fly   161 LLLDVLKNSAPSRIVVVSSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGS 225
            ..|..:|.....|::|.:|:....|          ..:.|  .|..||.|.......||..|...
Mouse   125 AFLPDMKRRHSGRVLVTASVGGLMG----------LPFHE--VYCASKFALEGLCESLAILLPLF 177

  Fly   226 GVTVNALHPGVVDTELARNWAFFQ-----------------TNLVKFFLKPMIWPLLKTPKSGAQ 273
            ||.|:.:..|.|.|      ||::                 .:|...:|:            |.:
Mouse   178 GVHVSLIECGAVHT------AFYEKLVGGPGGALERADAQTRHLFAHYLR------------GYE 224

  Fly   274 TSIYAALDPELKNISGLYFSDCK-PKP 299
            .::..|.|||  .::.|:.:..: |:|
Mouse   225 QALSEAQDPE--EVTELFLTAMRAPQP 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rdh1	NP_610310.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865	65/287 (23%)
Hsd17b1	NP_034605.1	Rossmann-fold NAD(P)(+)-binding proteins	4..260	CDD:473865	65/287 (23%)