DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2064 and RDH12

DIOPT Version :9

Sequence 1:	NP_610310.2	Gene:	CG2064 / 35708	FlyBaseID:	FBgn0033205	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_689656.2	Gene:	RDH12 / 145226	HGNCID:	19977	Length:	316	Species:	Homo sapiens

Alignment Length:	305	Identity:	155/305 - (50%)
Similarity:	198/305 - (64%)	Gaps:	20/305 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LKEYMQGGKFTKDTDETGKVFIVTGANTGIGKETALEIARRGGTVYLACRDMNRCEKARKDIIKE 90
            ::::..||....:....|||.::||||||||||||.|:|.||..||:||||:.:.|.|..:|..:
Human    22 IRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVD 86

  Fly    91 TNNQNIFSRELDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPKTLTKDGYELQLGVNHIGH 155
            |.|..:..|:||||...|||.|.:||..|:.:||:||||||||.||.:.|.||:|..|||||:||
Human    87 TKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGH 151

  Fly   156 FLLTNLLLDVLKNSAPSRIVVVSSLAHARGSINVADLNSEKSYDEGLAYSQSKLANVLFTRELAK 220
            ||||.|||:.||.|||:|:|.|||:||..|.|...||.|||.|..|.||..||||||||||||||
Human   152 FLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAK 216

  Fly   221 RLEGSGVTVNALHPGVVDTELARN-------WAFFQTNLVKFFLKPMIWPLLKTPKSGAQTSIYA 278
            ||:|:|||..|:|||||.:||.|:       |..|.             |.:||.:.|||||::.
Human   217 RLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFS-------------PFVKTAREGAQTSLHC 268

  Fly   279 ALDPELKNISGLYFSDCKPKPVASGALDDKVAKFLWAESEKWTGL 323
            ||...|:.:||.||||||...|:..|.::|.|:.||..|.:..|:
Human   269 ALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2064	NP_610310.2	PRK06197	40..322	CDD:235737	152/288 (53%)
CG2064	NP_610310.2	NADB_Rossmann	43..317	CDD:304358	151/280 (54%)
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	151/280 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		otm41333
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.820