DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2065 and Wwox

DIOPT Version :9

Sequence 1:	NP_001260787.1	Gene:	CG2065 / 35707	FlyBaseID:	FBgn0033204	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_062519.2	Gene:	Wwox / 80707	MGIID:	1931237	Length:	414	Species:	Mus musculus

Alignment Length:	305	Identity:	118/305 - (38%)
Similarity:	173/305 - (56%)	Gaps:	33/305 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQGGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQ 65
            :||..|      ||||.:|||||:|||.||....|..|..|.:|||:::|..:|...|:.|.:..
Mouse   117 LQGRDF------TGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKA 175

  Fly    66 NIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLT 130
            .:.:..|||:.|.|::.||..||.:...||||:.|||....|..|||||.|....|||:|||.|.
Mouse   176 KVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLV 240

  Fly   131 HLLLDVLKKTAPSRIVNVSSLVH-------TQGFIKTADLNSEKS-YSRIGAYSQSKLANVLFTR 187
            .||.|||.:::|:|::.|||..|       :.|.:..:.|:..:| |..:.||::|||.|:||:.
Mouse   241 QLLQDVLCRSSPARVIVVSSESHRFTDINDSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSN 305

  Fly   188 ELAKRLEGTGVTTNSLHPG-AVDTELSRN-WKF-----LKHPFAQLLLKPLLWVLFKTPRNGAQT 245
            ||.:||...|||:|::||| .:.:.:.|| |.:     |..||.            |:.:.||.|
Mouse   306 ELHRRLSPRGVTSNAVHPGNMMYSAIHRNSWVYKLLFTLARPFT------------KSMQQGAAT 358

  Fly   246 TLYAALDPALKDVSGLYFSDCQPKEVSAAAQDDKTGKFLWAESEK 290
            |:|.|:.|.|:.:.|:||::|.....|..||.::|.:.||..||:
Mouse   359 TVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALWELSER 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_001260787.1	PRK06197	11..294	CDD:235737	115/295 (39%)
CG2065	NP_001260787.1	NADB_Rossmann	14..288	CDD:304358	112/288 (39%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	19..47	CDD:238122
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122
		PRK06196	107..404	CDD:235736	118/305 (39%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	114/292 (39%)
		Interaction with MAPT. /evidence=ECO:0000269\|PubMed:15126504	125..414		113/291 (39%)
		Mediates targeting to the mitochondria	209..273		28/63 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710