Protein Alignment CG2065 and DHRS12

DIOPT Version :10

• Sequence 1: NP_610309.1
• Gene: CG2065 / 35707
• FlyBaseID: FBgn0033204
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: XP_047286575.1
• Gene: DHRS12 / 79758
• HGNCID: 25832
• Length: 346
• Species: Homo sapiens
• Alignment Length: 284
• Identity: 104/284 - (36%)
• Similarity: 144/284 - (50%)
• Gaps: 54/284 - (19%)

  Fly    14 GKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELDLSSLE 78
            |:||:|||.|:||||.|.||||||||||::.|||....|.||.:||||:.|||||...:|||..:
Human    40 GRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPK 104

  Fly    79 SIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLTHLLLDVLKKTAPS 143
            .|.||...||:|. ||||||||||.|...|.||:||.|.....|.:|.::||..|:.||:|....
Human   105 QIWKFVENFKQEH-KLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDP 168

  Fly   144 RI-VNVSSLVHTQGF----------------------IKTADLNSEKS-YSRIGAYSQSKLA--- 181
            |: ..:.|....||.                      :.|.||.||:: :.....|:|:|::
Human   169 RVQKGLGSCSSVQGLGMRSVSWSIQITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKVSERQ 233

  Fly   182 NVLFTRELAKRLEG-TGVTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLLWVLFKTPRNGAQT 245
            .|:.|...|   :| ..:..:|:|||..||. .||.:.|:....:                 |||
Human   234 QVVLTERWA---QGHPAIHFSSMHPGWADTP-DRNEQELRKVVGE-----------------AQT 277

  Fly   246 TLYAALDPALKDVSGLYFSDCQPK 269
               |:..|...::. ::...|||:
Human   278 ---ASPLPRFLEIM-MHEGKCQPQ 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_610309.1	Rossmann-fold NAD(P)(+)-binding proteins	14..288	CDD:473865	104/284 (37%)
DHRS12	XP_047286575.1	Rossmann-fold NAD(P)(+)-binding proteins	40..>261	CDD:473865	92/224 (41%)