Protein Alignment CG2065 and RDH14

DIOPT Version :10

• Sequence 1: NP_610309.1
• Gene: CG2065 / 35707
• FlyBaseID: FBgn0033204
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_065956.1
• Gene: RDH14 / 57665
• HGNCID: 19979
• Length: 336
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 145/298 - (48%)
• Similarity: 185/298 - (62%)
• Gaps: 23/298 - (7%)

  Fly    14 GKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQ------------- 65
            ||..::||||:|:|:.|..|:.:.|..|.|.|||..|.|:|...:.||....
Human    43 GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVG 107

  Fly    66 NIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLT 130
            .:..|||||:||.|:|.|.....:|:.:|.|||||||:..||...|:||||||.||||:||||||
Human   108 ELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLT 172

  Fly   131 HLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRELAKRLEG 195
            :|||.:||.:||||||.|||.::..|.|...|||||:||::...||:|||||:|||||||:||||
Human   173 NLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEG 237

  Fly   196 TGVTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLL----WVLFKTPRNGAQTTLYAALDPALK 256
            |.||.|.||||.|.|.|.|      |....||:|||.    |..||||..||||::|.|..|.::
Human   238 TNVTVNVLHPGIVRTNLGR------HIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVE 296

  Fly   257 DVSGLYFSDCQPKEVSAAAQDDKTGKFLWAESEKWTGV 294
            .|||.||.||:.:|:...|.|:...:.||..||...|:
Human   297 GVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_610309.1	Rossmann-fold NAD(P)(+)-binding proteins	14..288	CDD:473865	142/290 (49%)
RDH14	NP_065956.1	retinol-DH_like_SDR_c	43..328	CDD:212495	142/290 (49%)