DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2065 and WWOX

DIOPT Version :10

Sequence 1:NP_610309.1 Gene:CG2065 / 35707 FlyBaseID:FBgn0033204 Length:300 Species:Drosophila melanogaster
Sequence 2:NP_057457.1 Gene:WWOX / 51741 HGNCID:12799 Length:414 Species:Homo sapiens


Alignment Length:304 Identity:119/304 - (39%)
Similarity:171/304 - (56%) Gaps:31/304 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQGGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQ 65
            :||..|      ||||.:|||||:|||.||....|..|..|.:|||:|.|..:|...|:.|.:..
Human   117 LQGRDF------TGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKA 175

  Fly    66 NIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLT 130
            .:.:..|||:.|.|::.||..||.:...||||:.||.....|.:|||||.|....|||:|||.|.
Human   176 KVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLV 240

  Fly   131 HLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLN---SEKSYSRIG----------AYSQSKLAN 182
            .||.|||.::||:|::.|||..|     :..|:|   .:..:||:.          ||::|||.|
Human   241 QLLQDVLCRSAPARVIVVSSESH-----RFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCN 300

  Fly   183 VLFTRELAKRLEGTGVTTNSLHPG-AVDTELSRNWKFLKHPFAQLLLKPLLWVLFKTPRNGAQTT 246
            :||:.||.:||...|||:|::||| .:.:.:.|:|      :...||..|.....|:.:.||.||
Human   301 ILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSW------WVYTLLFTLARPFTKSMQQGAATT 359

  Fly   247 LYAALDPALKDVSGLYFSDCQPKEVSAAAQDDKTGKFLWAESEK 290
            :|.|..|.|:.:.|:||::|.....|..||.::|.:.|||.||:
Human   360 VYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSER 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2065NP_610309.1 Rossmann-fold NAD(P)(+)-binding proteins 14..288 CDD:473865 113/287 (39%)
WWOXNP_057457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WW 18..47 CDD:459800
Nuclear localization signal. /evidence=ECO:0000250 50..55
WW 60..90 CDD:238122
human_WWOX_like_SDR_c-like 124..407 CDD:187669 115/291 (40%)
Interaction with MAPT. /evidence=ECO:0000250 125..414 114/290 (39%)
Mediates targeting to the mitochondria. /evidence=ECO:0000250 209..273 30/68 (44%)
Blue background indicates that the domain is not in the aligned region.

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