DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2065 and RDH11

DIOPT Version :9

Sequence 1:	NP_001260787.1	Gene:	CG2065 / 35707	FlyBaseID:	FBgn0033204	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_057110.3	Gene:	RDH11 / 51109	HGNCID:	17964	Length:	318	Species:	Homo sapiens

Alignment Length:	289	Identity:	153/289 - (52%)
Similarity:	195/289 - (67%)	Gaps:	14/289 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQGGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQ 65
            :..|..|......|||.:||||||||||||..|:|:||..||:||||:.:.|...::|...|.||
Human    28 LSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQ 92

  Fly    66 NIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLT 130
            .:..|:||||..:|||.||.||..|:..|||||||||||.||.:.|.|||||.:||||:||||||
Human    93 QVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLT 157

  Fly   131 HLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRELAKRLEG 195
            ||||:.||::|||||||||||.|..|.|...:|..||.|:...||..|||||:|||:|||:||:|
Human   158 HLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQELARRLKG 222

  Fly   196 TGVTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLLWVLF----KTPRNGAQTTLYAALDPALK 256
            :||||.|:|||.|.:||.|:..|::          .:|.||    |||:.||||:|:.||...|:
Human   223 SGVTTYSVHPGTVQSELVRHSSFMR----------WMWWLFSFFIKTPQQGAQTSLHCALTEGLE 277

  Fly   257 DVSGLYFSDCQPKEVSAAAQDDKTGKFLW 285
            .:||.:||||....|||.|:::...:.||
Human   278 ILSGNHFSDCHVAWVSAQARNETIARRLW 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_001260787.1	PRK06197	11..294	CDD:235737	151/279 (54%)
CG2065	NP_001260787.1	NADB_Rossmann	14..288	CDD:304358	151/276 (55%)
RDH11	NP_057110.3	PRK06197	41..314	CDD:235737	151/276 (55%)
RDH11	NP_057110.3	NADB_Rossmann	41..309	CDD:304358	151/276 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H100724
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		otm41333
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.820