DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2065 and rdh12

DIOPT Version :9

Sequence 1:	NP_001260787.1	Gene:	CG2065 / 35707	FlyBaseID:	FBgn0033204	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_001002325.1	Gene:	rdh12 / 436597	ZFINID:	ZDB-GENE-040718-9	Length:	319	Species:	Danio rerio

Alignment Length:	292	Identity:	145/292 - (49%)
Similarity:	194/292 - (66%)	Gaps:	6/292 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNI 67
            ||.........|||.:|||||:||||||.|::|.||..|.:||||:.:.|:|..:|........:
Zfish    31 GGSCRSTVRLDGKVALVTGANSGIGKETALDLASRGARVILACRDLEKAEEAAAEIRTRVGGAKV 95

  Fly    68 FSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLTHL 132
            ..|||||:...|||.||..|.:|.|.||:||||||||.||...|.||||||:||||:||:|||:|
Zfish    96 EVRELDLADCCSIRAFAQRFLREVDHLHILINNAGVMMCPYMKTADGFEMQIGVNHLGHYLLTYL 160

  Fly   133 LLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRELAKRLEGTG 197
            |:.:||::||||||.||||.|..|:|:..||:|:.||:...||.||||||||||||||:||:|:.
Zfish   161 LIGLLKRSAPSRIVVVSSLAHNFGWIRFHDLHSQGSYNSGLAYCQSKLANVLFTRELARRLQGSN 225

  Fly   198 VTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLLWVLFKTPRNGAQTTLYAALDPALKDVSGLY 262
            ||.||:|||.|.:||      ::|.....||.....:..|:|:.||||::|.|:...|:.:||.:
Zfish   226 VTVNSVHPGTVRSEL------VRHSTLMSLLFAFFSMFLKSPKEGAQTSIYCAVAEELQSISGKH 284

  Fly   263 FSDCQPKEVSAAAQDDKTGKFLWAESEKWTGV 294
            ||||.|..|:...:.::|.:.||..|.:..|:
Zfish   285 FSDCAPAFVAPQGRSEETARKLWDVSCELLGI 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_001260787.1	PRK06197	11..294	CDD:235737	142/282 (50%)
CG2065	NP_001260787.1	NADB_Rossmann	14..288	CDD:304358	141/273 (52%)
rdh12	NP_001002325.1	PRK06197	41..318	CDD:235737	143/282 (51%)
rdh12	NP_001002325.1	NADB_Rossmann	42..310	CDD:304358	141/273 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9897
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		mtm6476
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.820