DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2065 and wwox

DIOPT Version :9

Sequence 1:	NP_001260787.1	Gene:	CG2065 / 35707	FlyBaseID:	FBgn0033204	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	NP_957207.1	Gene:	wwox / 393887	ZFINID:	ZDB-GENE-040426-858	Length:	412	Species:	Danio rerio

Alignment Length:	297	Identity:	121/297 - (40%)
Similarity:	172/297 - (57%)	Gaps:	17/297 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNIFSRELDLS 75
            |.:.||.||||||:|||.||....|..|..|.:|||:.:|..||...|:.|.:...:....|||:
Zfish   118 DLSDKVIIVTGANSGIGFETARSFALHGAHVILACRNQSRASKAASLIMGEWSKARVEVLPLDLA 182

  Fly    76 SLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLTHLLLDVLKKT 140
            ||.|:|:||..||..:..||||:.||.|...|..||:||||....:.|:|||||..||.|||:.:
Zfish   183 SLRSVRQFAELFKATKLPLHVLVCNAAVCSQPWRLTEDGFESTFQICHLGHFLLVQLLQDVLRLS 247

  Fly   141 APSRIVNVSS-------LVHTQGFIKTADLNS--EKSYSRIGAYSQSKLANVLFTRELAKRLEGT 196
            ||:|:|.|||       |:.:.|.: ..||.|  :|:|..:.||:::||.|:||:.||.:|:...
Zfish   248 APARVVVVSSESHRFTDLLDSCGNL-DLDLLSPPQKNYWSLLAYNRAKLCNLLFSSELHRRMSPH 311

  Fly   197 GVTTNSLHPGA-VDTELSRNWKFLKHPFAQLLLKPLLWVLFKTPRNGAQTTLYAALDPALKDVSG 260
            |:..|:||||: :.|.:.|:|..|...|:  |.:|..    |:.:.||.||:|.|:.|.|:.:.|
Zfish   312 GICCNALHPGSMMFTSIHRSWWLLTLLFS--LARPFT----KSMQQGAATTVYCAVAPELEGIGG 370

  Fly   261 LYFSDCQPKEVSAAAQDDKTGKFLWAESEKWTGVNST 297
            :||::|.....|..|||......||..||:.....||
Zfish   371 MYFNNCFRCLPSPQAQDPAAALSLWELSERLVQERST 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_001260787.1	PRK06197	11..294	CDD:235737	119/292 (41%)
CG2065	NP_001260787.1	NADB_Rossmann	14..288	CDD:304358	116/283 (41%)
wwox	NP_957207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	18..47	CDD:278809
		Nuclear localization signal. /evidence=ECO:0000250	50..55
		WW	59..88	CDD:278809
		PRK06196	108..402	CDD:235736	119/290 (41%)
		human_WWOX_like_SDR_c-like	121..404	CDD:187669	118/289 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810