DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2065 and Wwox

DIOPT Version :9

Sequence 1:	NP_001260787.1	Gene:	CG2065 / 35707	FlyBaseID:	FBgn0033204	Length:	300	Species:	Drosophila melanogaster
Sequence 2:	XP_006255728.1	Gene:	Wwox / 292041	RGDID:	1309927	Length:	414	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	119/310 - (38%)
Similarity:	171/310 - (55%)	Gaps:	43/310 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQGGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQ 65
            :||..|      ||||.:|||||:|||.||....|..|..|.:|||:|:|..:|...|:.|.:..
  Rat   117 LQGRDF------TGKVVLVTGANSGIGFETAKSFALHGAHVILACRNMSRASEAVSRILEEWHKA 175

  Fly    66 NIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLT 130
            .:.:..|||:.|.|::.||..||.:...||:|:.|||....|.:|||||.|....|||:|||.|.
  Rat   176 KVEAMTLDLAVLRSVQHFAEAFKAKNVPLHILVCNAGTFALPWSLTKDGLETTFQVNHLGHFYLV 240

  Fly   131 HLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLN-------------SEKSYSRIGAYSQSKLAN 182
            .||.|||.::||:|::.|||..|     :..|:|             |...|..:.||::|||.|
  Rat   241 QLLQDVLCRSAPARVIVVSSESH-----RFTDINDSSGKLDLSRLSLSSSDYWAMLAYNRSKLCN 300

  Fly   183 VLFTRELAKRLEGTGVTTNSLHPG-AVDTELSRN-WKF-----LKHPFAQLLLKPLLWVLFKTPR 240
            :||:.||.:.|...|||:|:|||| .:.:.:.|| |.:     |..||.            |:.:
  Rat   301 ILFSNELHRLLSPRGVTSNALHPGNMMFSAIHRNSWVYKLLFTLARPFT------------KSMQ 353

  Fly   241 NGAQTTLYAALDPALKDVSGLYFSDCQPKEVSAAAQDDKTGKFLWAESEK 290
            .||.||:|.|:.|.|:.:.|:||::|.....|..||:::|.:.||..||:
  Rat   354 QGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQNEETARALWELSER 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_001260787.1	PRK06197	11..294	CDD:235737	116/300 (39%)
CG2065	NP_001260787.1	NADB_Rossmann	14..288	CDD:304358	113/293 (39%)
Wwox	XP_006255728.1	WW	18..47	CDD:395320
		WW	60..90	CDD:238122
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	115/297 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810