Protein Alignment CG2065 and RDH12

DIOPT Version :10

• Sequence 1: NP_610309.1
• Gene: CG2065 / 35707
• FlyBaseID: FBgn0033204
• Length: 300
• Species: Drosophila melanogaster
• Sequence 2: NP_689656.2
• Gene: RDH12 / 145226
• HGNCID: 19977
• Length: 316
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 161/296 - (54%)
• Similarity: 200/296 - (67%)
• Gaps: 14/296 - (4%)

  Fly     3 GGQFTKQTDETGKVFIVTGANTGIGKETVLEIAKRGGTVYMACRDMNRCEKARQDIIRETNNQNI 67
            ||.........|||.::|||||||||||..|:|.||..||:||||:.:.|.|..:|..:|.|..:
Human    28 GGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQV 92

  Fly    68 FSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGFEMQLGVNHMGHFLLTHL 132
            ..|:||||..:|||.||.||..|:.:||:||||||||.||.:.|.||||..|||||:||||||:|
Human    93 LVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYL 157

  Fly   133 LLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRELAKRLEGTG 197
            ||:.||.:||:|:|||||:.|..|.|...||.|||.|||..||..||||||||||||||||:|||
Human   158 LLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTG 222

  Fly   198 VTTNSLHPGAVDTELSRNWKFLKHPFAQLLLKPLLWVLF----KTPRNGAQTTLYAALDPALKDV 258
            |||.::|||.|.:||.|:        :.||.  |||.||    ||.|.||||:|:.||...|:.:
Human   223 VTTYAVHPGVVRSELVRH--------SSLLC--LLWRLFSPFVKTAREGAQTSLHCALAEGLEPL 277

  Fly   259 SGLYFSDCQPKEVSAAAQDDKTGKFLWAESEKWTGV 294
            ||.|||||:...||..|:::||.:.||..|.:..|:
Human   278 SGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGI 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2065	NP_610309.1	Rossmann-fold NAD(P)(+)-binding proteins	14..288	CDD:473865	157/277 (57%)
RDH12	NP_689656.2	retinol-DH_like_SDR_c	39..307	CDD:212495	157/277 (57%)