DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2070 and Wwox

DIOPT Version :9

Sequence 1:	NP_001260786.1	Gene:	CG2070 / 35706	FlyBaseID:	FBgn0033203	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_062519.2	Gene:	Wwox / 80707	MGIID:	1931237	Length:	414	Species:	Mus musculus

Alignment Length:	315	Identity:	124/315 - (39%)
Similarity:	180/315 - (57%)	Gaps:	27/315 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMK 78
            |..:.:|:.|      :||..|      ||:|.:|||.|.|||.||....|..||.|.:|||::.
Mouse   107 YDGSTTAMEI------LQGRDF------TGKVVLVTGANSGIGFETAKSFALHGAHVILACRNLS 159

  Fly    79 KCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDG 143
            :...|...|::..:...:.|..|||..::|:::||..||.:...||:|:.|||....|..||:||
Mouse   160 RASEAVSRILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVSLHVLVCNAGTFALPWGLTKDG 224

  Fly   144 FEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRF-------GRIKRDDLNSEKS-YDR 200
            .|....|||:|||.|..||.|||..|:|:||:|:||.:|||       |::....|:..:| |..
Mouse   225 LETTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSESHRFTDINDSSGKLDLSRLSPPRSDYWA 289

  Fly   201 KMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPG-VVNTELFRNTPFLGSWFGKLLIAPIIWIF 264
            .:||.:|||.|:||:.||.:|||..|||.||:||| ::.:.:.||     ||..|||.. :...|
Mouse   290 MLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHRN-----SWVYKLLFT-LARPF 348

  Fly   265 IKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEK 319
            .|:.:.||.||:|.|:.|.||.:.|.||::|.:......||.::.|:.||..||:
Mouse   349 TKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEETARALWELSER 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2070	NP_001260786.1	PRK06197	41..323	CDD:235737	118/288 (41%)
CG2070	NP_001260786.1	NADB_Rossmann	43..317	CDD:304358	115/282 (41%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	19..47	CDD:238122
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122
		PRK06196	107..404	CDD:235736	124/315 (39%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	117/286 (41%)
		Interaction with MAPT. /evidence=ECO:0000269\|PubMed:15126504	125..414		116/285 (41%)
		Mediates targeting to the mitochondria	209..273		31/63 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710