DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG2070 and WWOX

DIOPT Version :10

Sequence 1:NP_610308.2 Gene:CG2070 / 35706 FlyBaseID:FBgn0033203 Length:325 Species:Drosophila melanogaster
Sequence 2:NP_057457.1 Gene:WWOX / 51741 HGNCID:12799 Length:414 Species:Homo sapiens


Alignment Length:315 Identity:123/315 - (39%)
Similarity:178/315 - (56%) Gaps:27/315 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 YGSALSAIGIYLLRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATVYMACRDMK 78
            |..:.:|:.|      :||..|      ||:|.:|||.|.|||.||....|..||.|.:|||:|.
Human   107 YDGSTTAMEI------LQGRDF------TGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMA 159

  Fly    79 KCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDCPKMLTEDG 143
            :...|...|::..:...:.|..|||..::|:::||..||.:...||:|:.||.....|..||:||
Human   160 RASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDG 224

  Fly   144 FEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRF-------GRIKRDDLNSEKS-YDR 200
            .|....|||:|||.|..||.|||..|||:||:|:||.:|||       |::....|:..|: |..
Human   225 LETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWA 289

  Fly   201 KMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPG-VVNTELFRNTPFLGSWFGKLLIAPIIWIF 264
            .:||.:|||.|:||:.||.:|||..|||.||:||| ::.:.:.|      ||:...|:..:...|
Human   290 MLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHR------SWWVYTLLFTLARPF 348

  Fly   265 IKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEK 319
            .|:.:.||.||:|.|..|.||.:.|.||::|.:......||.::.|:.|||.||:
Human   349 TKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSER 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2070NP_610308.2 Rossmann-fold NAD(P)(+)-binding proteins 43..317 CDD:473865 114/282 (40%)
WWOXNP_057457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
WW 18..47 CDD:459800
Nuclear localization signal. /evidence=ECO:0000250 50..55
WW 60..90 CDD:238122
human_WWOX_like_SDR_c-like 124..407 CDD:187669 116/286 (41%)
Interaction with MAPT. /evidence=ECO:0000250 125..414 115/285 (40%)
Mediates targeting to the mitochondria. /evidence=ECO:0000250 209..273 31/63 (49%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.