DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2070 and rdh12

DIOPT Version :9

Sequence 1:	NP_001260786.1	Gene:	CG2070 / 35706	FlyBaseID:	FBgn0033203	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_001002325.1	Gene:	rdh12 / 436597	ZFINID:	ZDB-GENE-040718-9	Length:	319	Species:	Danio rerio

Alignment Length:	318	Identity:	155/318 - (48%)
Similarity:	210/318 - (66%)	Gaps:	12/318 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LAYGSALSAIGIYL------LRQYMQGGQFTTKTNETGRVAIVTGCNQGIGKETVLELARRGATV 70
            :|:.:.|..:.:.|      :|:|..||...:.....|:||:|||.|.||||||.|:||.|||.|
Zfish     5 VAFAAGLGLVALILRLLSPQIRKYAAGGSCRSTVRLDGKVALVTGANSGIGKETALDLASRGARV 69

  Fly    71 YMACRDMKKCENARREIIKATNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHILINNAGIMDC 135
            .:||||::|.|.|..||........:..|:|||....|||.||..|.||.:.|||||||||:|.|
Zfish    70 ILACRDLEKAEEAAAEIRTRVGGAKVEVRELDLADCCSIRAFAQRFLREVDHLHILINNAGVMMC 134

  Fly   136 PKMLTEDGFEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDR 200
            |.|.|.|||||||||||:||:|||.||:.:||.|||||:||:||:||.||.|:..||:|:.||:.
Zfish   135 PYMKTADGFEMQIGVNHLGHYLLTYLLIGLLKRSAPSRIVVVSSLAHNFGWIRFHDLHSQGSYNS 199

  Fly   201 KMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPGVVNTELFRNTPFLGSWFGKLLIAPIIWIFI 265
            .:|||||||||||||||||:||.|:.||||::|||.|.:||.|::..:.      |:.....:|:
Zfish   200 GLAYCQSKLANVLFTRELARRLQGSNVTVNSVHPGTVRSELVRHSTLMS------LLFAFFSMFL 258

  Fly   266 KTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESEKWTGI 323
            |:.:.||||::|.|:...|:.:||::||||....|....:.::.|:.||..|.:..||
Zfish   259 KSPKEGAQTSIYCAVAEELQSISGKHFSDCAPAFVAPQGRSEETARKLWDVSCELLGI 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2070	NP_001260786.1	PRK06197	41..323	CDD:235737	146/281 (52%)
CG2070	NP_001260786.1	NADB_Rossmann	43..317	CDD:304358	145/273 (53%)
rdh12	NP_001002325.1	PRK06197	41..318	CDD:235737	148/282 (52%)
rdh12	NP_001002325.1	NADB_Rossmann	42..310	CDD:304358	145/273 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9897
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	1	1.000	-	-		mtm6476
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	1	1.100	-	-	O	PTHR24320
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.820