Protein Alignment CG2070 and C2orf81

DIOPT Version :10

• Sequence 1: NP_610308.2
• Gene: CG2070 / 35706
• FlyBaseID: FBgn0033203
• Length: 325
• Species: Drosophila melanogaster
• Sequence 2: NP_001303693.1
• Gene: C2orf81 / 388963
• HGNCID: 34350
• Length: 615
• Species: Homo sapiens
• Alignment Length: 675
• Identity: 129/675 - (19%)
• Similarity: 212/675 - (31%)
• Gaps: 223/675 - (33%)

  Fly  2282 QAEFTVQKVGQCLIDVLHQSKPLMGSPYTCESYDPTKIQLQKVPKMNLCANSPISWIVQSESAGV 2346
            :|:.:.:..|....|.:.|...|:       |.:..|::.....|.||   :|.|.:|:  .||.
Human   164 KAQLSTKTSGLLGADPVVQQDSLL-------SANEMKLKRPAREKRNL---APSSQLVR--VAGK 216

  Fly  2347 AEIE---------------VTVLSPTGQNVPVKLTQQDDYEHSIEFVPQAAGHYKATVMYGGEAV 2396
            |.:|               .|.||.|.|  |:..:|.........|:|       |||: |....
Human   217 APLERQKKGDPSARPQNEPHTALSQTFQ--PMSGSQVLTESSVPPFLP-------ATVV-GPRRA 271

  Fly  2397 P---NSPITFAVQSAGGKSDSHASGNGLEVAHRGKETSFVVFCPTAPNVQIER----TDEQAERI 2454
            |   :....::..|...:.:::.:    |...|.:|...:....:.|:.:..|    :..|...:
Human   272 PFRFHDEDFYSALSLNNEQENYDT----EEETRTEEELLLAGMRSPPSYKRSRFLGTSAAQNRNV 332

  Fly  2455 EPRIKNMGNNQWKIFYTILTVGRYEIRASCTNRGPLPGSPWNIACLDPAKVTPIGGWGSCLDSSG 2519
            |...:|:..|                  |.....|.||||...:..:|.......|.....|:.
Human   333 EENAENLRGN------------------SLRRSEPNPGSPRKTSVTEPTTKQSSPGQRMLQDTR- 378

  Fly  2520 KLVLPSKIVFDTSMAGPGELTCYVDDA------EVMVEKQGSGKCVLFLSDDALAKGEHSFDLTW 2578
               ||.::..|.......|.|....||      :|..| ..|..|.:   :|..|  .|:.:..|
Human   379 ---LPRELAKDNPSGDQDEKTPVPGDAKSDGVTQVSAE-DVSNNCAV---EDRSA--VHNCERDW 434

  Fly  2579 SGLPISQSPGFVYVTGMTIGSDRVVLTGRGLTTAQVGEVSHFTIDATDALSGKPEVHMAYDDGEP 2643
            ..          |::|                       |..:.|.  .|||:|..
Human   435 QR----------YLSG-----------------------SRNSFDC--LLSGRPTA--------- 455

  Fly  2644 LPVTLLQPRPNELIWLASYNPHKSTGGPLSLEVEWNGRIIKGCPLTIPVG----PAVDAAKVL-- 2702
                   ||       ||.||..:..|.|     ::..:|...|.::.|.    |:.:..:.|
Human   456 -------PR-------ASVNPSYNAHGSL-----FHSAVIDDIPASLSVSSILVPSAELEENLRF 501

  Fly  2703 ---------------CSGEGLRNGVVGREIKSWIDTRRAGPGELTAHCAGPRKVAYCELYDHGDA 2752
                           .:.|.......|.|.::  .|.:|....|.:....|:            :
Human   502 NVRRPLSPIRNRNPSAASESHSEDTQGEEERA--STSQAQESPLLSDLPNPQ------------S 552

  Fly  2753 TFTLNVKPQEPGRHTLTIKYGGQHVPGSPYTLRVVGAPDASKVRVYGPGIEHGVLATFQSRFIVD 2817
            :..|...|..|.|..|   .|..::|||                     ::..:..||.:  :.|
Human   553 SMALGDSPSSPTRRHL---QGHFYMPGS---------------------LQENIPFTFFA--VSD 591

  Fly  2818 TRGAGAGQLTVRVRGPKGAFRVEMQRESQKDRTI---LCKYDPTEPGDYRVEVKWAGELVPGSPF 2879
            .........:|||.|.......|::.:.:|.|.:   |.:.|..|.||.....:.||    |||.
Human   592 FASQNDNGTSVRVSGVMDEKATEIKADPEKLRKLQESLLEEDSEEEGDLCRICQIAG----GSPA 652

  Fly  2880 PVLI----------FDTQEELKRFL 2894
            ..|:          |..||.||::|
Human   653 NPLLEPCGCVGSLQFVHQECLKKWL 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2070	NP_610308.2	Rossmann-fold NAD(P)(+)-binding proteins	43..317	CDD:473865
C2orf81	NP_001303693.1	DUF4639	9..614	CDD:464739	109/606 (18%)