DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2070 and Rdh14

DIOPT Version :9

Sequence 1:	NP_001260786.1	Gene:	CG2070 / 35706	FlyBaseID:	FBgn0033203	Length:	325	Species:	Drosophila melanogaster
Sequence 2:	NP_076186.1	Gene:	Rdh14 / 105014	MGIID:	1920402	Length:	334	Species:	Mus musculus

Alignment Length:	330	Identity:	150/330 - (45%)
Similarity:	204/330 - (61%)	Gaps:	32/330 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LSAIGIYLLRQYMQGGQFTTKTNET-----------GRVAIVTGCNQGIGKETVLELARRGATVY 71
            |:|:|..|   ::...:|:...|:.           |:..::||.|.|:|:.|..||.|.||.|.
Mouse    11 LAALGGAL---WLAARRFSGPRNQRQQGGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVI 72

  Fly    72 MACRDMKKCENA----RREIIKA-------TNNQNIFARQLDLCSMKSIRNFAAGFKREQNKLHI 125
            |.|||..:.|.|    |:|:.:|       |:.| :..::|||.|::|:|.|.....:|:.:|.:
Mouse    73 MGCRDRARAEEAAGQLRQELCQAGGAGPDGTDGQ-LVVKELDLASLRSVRAFCQELLQEEPRLDV 136

  Fly   126 LINNAGIMDCPKMLTEDGFEMQIGVNHMGHFLLTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRD 190
            ||||||:..||...||||||||.||||:||||||.|||.:||||||||:||:||..:::|.|..:
Mouse   137 LINNAGVFHCPYTKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGEINFE 201

  Fly   191 DLNSEKSYDRKMAYCQSKLANVLFTRELAKRLSGTGVTVNALHPGVVNTELFR--NTPFLGSWFG 253
            |||||:||::...|.:|||||:|||||||:||.||.||||.||||:|.|.|.|  :.|.|    .
Mouse   202 DLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLL----A 262

  Fly   254 KLLIAPIIWIFIKTARNGAQTTLYAALDPSLEKVSGRYFSDCKQKHVGSAAQYDDDAQFLWAESE 318
            :.|...:.|.|.||...||||::|.|..|.:|.||||||.|||::.:...|..:..|:.||..||
Mouse   263 RPLFNLVSWAFFKTPLEGAQTSIYLACSPDVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISE 327

  Fly   319 KWTGI 323
            ...||
Mouse   328 VMVGI 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2070	NP_001260786.1	PRK06197	41..323	CDD:235737	142/305 (47%)
CG2070	NP_001260786.1	NADB_Rossmann	43..317	CDD:304358	140/286 (49%)
Rdh14	NP_076186.1	PRK06197	43..332	CDD:235737	142/293 (48%)
Rdh14	NP_076186.1	NADB_Rossmann	44..326	CDD:304358	140/286 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53570
OrthoDB	1	1.010	-	-		D414554at33208
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1905
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760