DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30491 and Wwox

DIOPT Version :9

Sequence 1:	NP_001260784.1	Gene:	CG30491 / 35704	FlyBaseID:	FBgn0050491	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_062519.2	Gene:	Wwox / 80707	MGIID:	1931237	Length:	414	Species:	Mus musculus

Alignment Length:	336	Identity:	129/336 - (38%)
Similarity:	184/336 - (54%)	Gaps:	37/336 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLKSRTAFWLS-----------FTGTTTGLAFFVKDLMQGGQFTKETNETGKVFIVTGANTGIGK 59
            :|..|.||.:.           :.|:||.:     :::||..|      ||||.:|||||:|||.
Mouse    85 YLDPRLAFTVDDNPTKPTTRQRYDGSTTAM-----EILQGRDF------TGKVVLVTGANSGIGF 138

  Fly    60 ETVREIAKRGGTVYMACRNLKKCEEAREEIVLETKNKYVYCRQCDLASQESIRHFVAAFKREQEH 124
            ||.:..|..|..|.:|||||.:..||...|:.|.....|.....|||...|::||..|||.:...
Mouse   139 ETAKSFALHGAHVILACRNLSRASEAVSRILEEWHKAKVEAMTLDLAVLRSVQHFAEAFKAKNVS 203

  Fly   125 LHVLINNAGVMRCPRSLTSDGIELQLGVNHMGHFLLTNLLLDLLKKSSPSRIVNVSSLAHTRGEI 189
            ||||:.|||....|..||.||:|....|||:|||.|..||.|:|.:|||:|::.|||.:|...:|
Mouse   204 LHVLVCNAGTFALPWGLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSSPARVIVVSSESHRFTDI 268

  Fly   190 N--TGDLNSDK------SYDEGKAYSQSKLANVLFTRELAKRLEGTNVTANALHPG-VVDTEIIR 245
            |  :|.|:..:      .|....||::|||.|:||:.||.:||....||:||:||| ::.:.|.|
Mouse   269 NDSSGKLDLSRLSPPRSDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSAIHR 333

  Fly   246 HMGFFNNFFAGLFVKPLFWPFVKTPRNGAQTSLYVALDPELEKVTGQYFSDCKLKEMAPAATDTQ 310
            :...:...|.      |..||.|:.:.||.|::|.|:.||||.:.|.||::|.....:..|...:
Mouse   334 NSWVYKLLFT------LARPFTKSMQQGAATTVYCAVAPELEGLGGMYFNNCCRCLPSEEAQSEE 392

  Fly   311 TAKWLWAVSEK 321
            ||:.||.:||:
Mouse   393 TARALWELSER 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30491	NP_001260784.1	PRK06197	43..323	CDD:235737	119/288 (41%)
CG30491	NP_001260784.1	NADB_Rossmann	45..319	CDD:304358	116/282 (41%)
Wwox	NP_062519.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		WW	19..47	CDD:238122
		Nuclear localization signal	50..55
		WW	60..90	CDD:238122	1/4 (25%)
		PRK06196	107..404	CDD:235736	125/314 (40%)
		human_WWOX_like_SDR_c-like	124..407	CDD:187669	118/286 (41%)
		Interaction with MAPT. /evidence=ECO:0000269\|PubMed:15126504	125..414		117/285 (41%)
		Mediates targeting to the mitochondria	209..273		30/63 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1208
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000061
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100091
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X72
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710