DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpt1 and RPT1

DIOPT Version :9

Sequence 1:	NP_477473.1	Gene:	Rpt1 / 35701	FlyBaseID:	FBgn0028687	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_012777.1	Gene:	RPT1 / 853712	SGDID:	S000001628	Length:	467	Species:	Saccharomyces cerevisiae

Alignment Length:	459	Identity:	319/459 - (69%)
Similarity:	369/459 - (80%)	Gaps:	35/459 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LGDDQRKVKHDEKEDKEIKSLDEGDIELLKTYGQSQYHKSIKSIEEDIQKAVKQVNELTGIKESD 69
            |.||.:|     .:|.:|..|.||||::||:||.:.|...:|..|.|::....::.|..|:||||
Yeast    14 LEDDDKK-----PDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIEARIKEKAGVKESD 73

  Fly    70 TGLAPPALWDLAADKQILQNEQPLQVARCTKII--NADSD------------------------- 107
            |||||..|||:..|:|.|..|.|||||||||||  |.:||
Yeast    74 TGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNNNSGNSNSNSNQQSTDADE 138

  Fly   108 ---DPKYIINVKQFAKFVVDLADSVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEDK 169
               |.||:||:||.|||||.|.:.|:||||||||||||||:||.|.:||||:|||:||||.||:|
Yeast   139 DDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSKYNIELPLPPRIDPSVTMMTVEEK 203

  Fly   170 PDVTYSDVGGCKEQIEKLREVVETPLLHPEKFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTD 234
            ||||||||||||:||||||||||.|||.||:|..|||:||||:||:|||||||||||||||||||
Yeast   204 PDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTD 268

  Fly   235 ACFIRVIGSELVQKYVGEGARMVRELFEMARSKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTM 299
            |.|||||||||||||||||||||||||||||:||||:||||||||:|||||||||||||||||||
Yeast   269 ATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTM 333

  Fly   300 LELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKVEFGLPDQDGRSHIFKIHARSMSV 364
            ||||.|||||||||||||:.|||||:||||||:||||:||||||.|||.:||::||:||::||||
Yeast   334 LELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSV 398

  Fly   365 ERDIRFDLLARLCPNSTGAEIRSVCTEAGMFAIRARRKVATEKDFLEAVKKVIKSYAKFSATPRY 429
            ||.||::|::||||||||||:|||||||||||||||||||||||||:||.|||..|.|||:|.||
Yeast   399 ERGIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRY 463

  Fly   430 MTYN 433
            |.||
Yeast   464 MQYN 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt1	NP_477473.1	RPT1	27..430	CDD:224143	308/432 (71%)
RPT1	NP_012777.1	RPT1	28..464	CDD:224143	309/435 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343118
Domainoid	1	1.000	250	1.000	Domainoid score	I344
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2096
Inparanoid	1	1.050	633	1.000	Inparanoid score	I118
Isobase	1	0.950	-	0	Normalized mean entropy	S70
OMA	1	1.010	-	-		QHG54011
OrthoFinder	1	1.000	-	-		FOG0004356
OrthoInspector	1	1.000	-	-		oto100393
orthoMCL	1	0.900	-	-		OOG6_101899
Panther	1	1.100	-	-	LDO	PTHR23073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1001
SonicParanoid	1	1.000	-	-		X3079
TreeFam	1	0.960	-	-
	16	15.740