DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt1 and ATAD2B

DIOPT Version :9

Sequence 1:	NP_477473.1	Gene:	Rpt1 / 35701	FlyBaseID:	FBgn0028687	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	450	Identity:	142/450 - (31%)
Similarity:	215/450 - (47%)	Gaps:	86/450 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 TYGQSQYHK--------------------SIKSIEED----IQKAVKQVNE----LTGIKESDTG 71
            :||...:|:                    ||:|.|||    :::|..:.|:    |...|..|..
Human   245 SYGIQNHHEVSTEGEEEARTSKLLPLEKISIESQEEDGDIEVEEAEGEENDRPYNLRQRKTVDRY 309

  Fly    72 LAPP-----------ALWDL----AADKQILQNEQPLQVARCTKIINADSDDPKYIINVKQFAKF 121
            .|||           .|:|:    |....|.:.:..:..:..|     .||:.::   .::.:|.
Human   310 QAPPIVPAHQKKRENTLFDIHRSPARRSHIRRKKHAIHSSDTT-----SSDEERF---ERRKSKS 366

  Fly   122 VVDLADSVAPTDIE-EGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEDKPDVTYSDVGGCKEQIE 185
            :....:...|.:.. |.:..|:.|.:.::...| ..:||    |.: || .|.:..:||....|.
Human   367 MARARNRCLPMNFRAEDLASGILRERVKVGASL-ADVDP----MNI-DK-SVRFDSIGGLSHHIH 424

  Fly   186 KLREVVETPLLHPEKFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTD------ACFIRVIGSE 244
            .|:|:|..|||:||.|....|:||:|.|.:|||||||||.|||:||...      |.|:|. |::
Human   425 ALKEMVVFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRK-GAD 488

  Fly   245 LVQKYVGEGARMVRELFEMARSKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGF 309
            .:.|:|||..|.:|.||:.|...:..:|||||||.:...|........:.:..|:|.|   :||.
Human   489 CLSKWVGESERQLRLLFDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGL 550

  Fly   310 DPRGNIKVLMATNRPDTLDPALMRPGRLDRKVEFGLPDQDGRSHIFKIHARSMSVE-RDIRFDLL 373
            |.||.|.|:.||||.|::||||.||||.||:..|.||||..|.||.:||.|..:.: .|.....|
Human   551 DNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHTRDWNPKLSDAFLGEL 615

  Fly   374 ARLCPNSTGAEIRSVCTEAGMFAIRARRK----------------VATEKDFLEAVKKVI 417
            |..|....||:|:::||||.:.|:|.|..                |.:.:||..|::.::
Human   616 AEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLDVSSIVLSAQDFYHAMQNIV 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt1	NP_477473.1	RPT1	27..430	CDD:224143	142/449 (32%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640	66/144 (46%)
		AAA	452..586	CDD:278434	62/137 (45%)
		COG5076	866..>1100	CDD:227408
		Bromo_AAA	974..1085	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900