DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt1 and Kat60

DIOPT Version :9

Sequence 1:	NP_477473.1	Gene:	Rpt1 / 35701	FlyBaseID:	FBgn0028687	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001262276.1	Gene:	Kat60 / 53566	FlyBaseID:	FBgn0040208	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	102/280 - (36%)
Similarity:	148/280 - (52%)	Gaps:	30/280 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 VEDKPDVTYSDVGGCKEQIEKLREVVETPLLHPEKFVNLGIEPP-KGVLLFGPPGTGKTLCARAV 229
            ::..|.|.:||:....:....|.|.|..|:|.|:.|  .||..| ||||:.||||||||:.|:||
  Fly   317 LQKDPKVRWSDIADLHDAKRLLEEAVVLPMLMPDYF--KGIRRPWKGVLMVGPPGTGKTMLAKAV 379

  Fly   230 ANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARSKKACLIFFDEIDAIGGARFDDGAGGDNE 294
            |......|..|..:.|..||.||..:|||.||||||......||.||||::...|   |:..::|
  Fly   380 ATECGTTFFNVSSATLTSKYRGESEKMVRLLFEMARFYAPSTIFIDEIDSLCSRR---GSESEHE 441

  Fly   295 V-QRTMLELINQLDGF----DPRGNIKVLMATNRPDTLDPALMRPGRLDRKVEFGLPDQDGRSHI 354
            . :|...||:.|:||.    :....:.||.|||.|..:|.||.|  ||::::...||..:||..:
  Fly   442 ASRRVKSELLVQMDGVGGGEEQAKVVMVLAATNFPWDIDEALRR--RLEKRIYIPLPSDEGREAL 504

  Fly   355 FKIHARSMSVERDIRFDLLARLCPNSTGAEIRSVCTEAGMFAIRAR---------RKVATE---- 406
            .||:.|.:.|:..:....:|......:||:|.:||.||.|.::|.:         |::|||
  Fly   505 LKINLREVKVDDSVDLTYVANELKGYSGADITNVCREASMMSMRRKIAGLTPEQIRQLATEEVDL 569

  Fly   407 ----KDFLEAVKKVIKSYAK 422
                |||.||:.:..||.::
  Fly   570 PVSNKDFNEAMSRCNKSVSR 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt1	NP_477473.1	RPT1	27..430	CDD:224143	102/280 (36%)
Kat60	NP_001262276.1	HCV_NS5a_C	<163..243	CDD:289693
		P-loop_NTPase	325..>381	CDD:304359	27/57 (47%)
		AAA	358..496	CDD:214640	60/142 (42%)
		AAA	362..495	CDD:278434	57/137 (42%)
		Vps4_C	<570..603	CDD:286426	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900