DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpt1 and ATAD2

DIOPT Version :9

Sequence 1:	NP_477473.1	Gene:	Rpt1 / 35701	FlyBaseID:	FBgn0028687	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_054828.2	Gene:	ATAD2 / 29028	HGNCID:	30123	Length:	1390	Species:	Homo sapiens

Alignment Length:	493	Identity:	146/493 - (29%)
Similarity:	224/493 - (45%)	Gaps:	94/493 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KVKHDEKEDKEIKSLDEGDIELLKTYGQSQYHKSIKSIE-----------EDIQKAVKQVNELTG 64
            |.|..::.|:|.....||.:|..:. |:.|.|:.....|           :|........:|..|
Human   223 KQKDIQRTDEETTDNQEGSVESSEE-GEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDG 286

  Fly    65 IKESDTGLAPPALWDLAADKQILQNEQPLQVARCTKIIN------ADSDDPKYIIN--------V 115
            .:|:.      ..:.|...|..:..:.||:..|..:..|      |....|:|.::        .
Human   287 EEENQ------KRYYLRQRKATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYC 345

  Fly   116 KQF--AKFVVDLADSVAPTDIEEGMRV--------------------------GVDRNKYQIHIP 152
            |:.  .:..:..:||.:.:..|:....                          |:.:::.:|...
Human   346 KRMNRRRHAIHSSDSTSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGAS 410

  Fly   153 LPPKIDPTVTMMQVEDKPDVTYSDVGGCKEQIEKLREVVETPLLHPEKFVNLGIEPPKGVLLFGP 217
            | ..:||    ||::.  .|.:..|||....|..|:|:|..|||:||.|....|:||:|.|.:||
Human   411 L-ADVDP----MQLDS--SVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGP 468

  Fly   218 PGTGKTLCARAVANRTD------ACFIRVIGSELVQKYVGEGARMVRELFEMARSKKACLIFFDE 276
            |||||||.|||:||...      |.|:|. |::.:.|:|||..|.:|.||:.|...:..:|||||
Human   469 PGTGKTLVARALANECSQGDKRVAFFMRK-GADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDE 532

  Fly   277 IDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKV 341
            ||.:...|........:.:..|:|.|   :||.|.||.|.|:.||||.|::||||.||||.||:.
Human   533 IDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREF 594

  Fly   342 EFGLPDQDGRSHIFKIHARSMSVE-RDIRFDLLARLCPNSTGAEIRSVCTEAGMFAIRAR----- 400
            .|.|||::.|..|.|||.|..:.: .|...:.||..|....||:|:|:|.||.:.|:|.|
Human   595 LFSLPDKEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIY 659

  Fly   401 ---RKVATE--------KDFLEAVKKVIKSYAKFSATP 427
               .|:..:        |||..|::|:|.:..:...:|
Human   660 TTSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSP 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt1	NP_477473.1	RPT1	27..430	CDD:224143	142/477 (30%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..380		28/163 (17%)
		AAA	459..600	CDD:214640	66/144 (46%)
		AAA	464..598	CDD:278434	62/137 (45%)
		COG5076	<915..1153	CDD:227408
		Bromo_AAA	987..1097	CDD:99957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900