DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43340 and CHS5

DIOPT Version :9

Sequence 1:	NP_001246184.1	Gene:	CG43340 / 35698	FlyBaseID:	FBgn0263077	Length:	3213	Species:	Drosophila melanogaster
Sequence 2:	NP_013434.1	Gene:	CHS5 / 851041	SGDID:	S000004322	Length:	671	Species:	Saccharomyces cerevisiae

Alignment Length:	837	Identity:	173/837 - (20%)
Similarity:	271/837 - (32%)	Gaps:	305/837 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1280 VKNQI--NSSNHMEQQN--ISIEPQPTVPMDTIQPIEIVQEVPCNTVDLIATTEAVNA-DHSEPG 1339
            :|.|:  |.....:|:|  .||:.:......|.:|     |.|...:..:..|..|.| |..:.|
Yeast    45 IKMQVSQNLEEEKKQRNHFKSIQAKILEKYGTHKP-----ESPVLKIVNVTQTSCVLAWDPLKLG 104

  Fly  1340 EAGLISEVLQFHSSGGDLPETDSRAIEPLPLAPPAEVIEVVPLGSAELLSPSEPTE----VVSPS 1400
            .|.|.|.:|.            .:.|..:.:..|.:|......|    ||...|.|    :::.|
Yeast   105 SAKLKSLILY------------RKGIRSMVIPNPFKVTTTKISG----LSVDTPYEFQLKLITTS 153

  Fly  1401 AIALPEKP--------------------EPMENATEIEIEEMVS-----PTSVEIVPTTT----E 1436
            .....||.                    :|::..::::|.:.:|     |....:...||    .
Yeast   154 GTLWSEKVILRTHKMTDMSGITVCLGPLDPLKEISDLQISQCLSHIGARPLQRHVAIDTTHFVCN 218

  Fly  1437 DLHQAESVVETAR------PVSAVEEVKPIE-------------DSTAAIDKSPQISPIEGEHSQ 1482
            ||...||..|..|      |:...|.|:..|             |:..:|.|:....|:..|...
Yeast   219 DLDNEESNEELIRAKHNNIPIVRPEWVRACEVEKRIVGVRGFYLDADQSILKNYTFPPVNEEELS 283

  Fly  1483 HSEKETPESVEVGLDSPNVADVITTSVEVIPTSTTAVTTSDGASTEMPEPPKIYCETAP------ 1541
            :|::..|.: ||..::....|  ||.||.:.:..   ......|....:..|...||||
Yeast   284 YSKENEPVA-EVADENKMPED--TTDVEQVASPN---DNESNPSEAKEQGEKSGHETAPVSPVED 342

  Fly  1542 --PAAEEIEQNETVETLSVSADTTLPEEIVSQDGNLEASEQTASIDVTFQANLNNMESKGCVEVA 1604
              .|:..:|...|:||::.|..:...|.:.:.
Yeast   343 PLHASTALENETTIETVNPSVRSLKSEPVGTP--------------------------------- 374

  Fly  1605 VDVRESKEDETLMEPIAVDVAVPVEVVPQCAGVELGVSEPEEATPATNNLTSGENPPEEVSELVD 1669
             ::.|:|.|                     :..|..|.||.||.        .|:.|.|
Yeast   375 -NIEENKAD---------------------SSAEAVVEEPNEAV--------AESSPNE------ 403

  Fly  1670 VEPRNPHEEIHTDSFEKDSQKSSDAVALHEDNTKSEEKVDPPQV-AEEVAPDIITLDPPSLVELS 1733
                           |...|||.|.      :|.|.|:.|...| .||||.:.||.:........
Yeast   404 ---------------EATGQKSEDT------DTHSNEQADNGFVQTEEVAENNITTESAGENNEP 447

  Fly  1734 PDTQAMAIGNIAPFDIILEPESIVIEQPVPVVKPETIVVESDPEAIDHTALLEPSVSAEVQDKVE 1798
            .|..||..|         .||: .||.|                              ||.:.:|
Yeast   448 ADDAAMEFG---------RPEA-EIETP------------------------------EVNESIE 472

  Fly  1799 SAQQQVSENKSVEEDSLKVSIGERGEIISMDPITPAD-AVSEQNFRVED---PITSTESTAVEVI 1859
            .|.:...::....|||.|             |:..:: .|.:.|..|||   |:..:.....:
Yeast   473 DANEPAEDSNEPVEDSNK-------------PVKDSNKPVEDSNKPVEDSNKPVEDSNKPVED-- 522

  Fly  1860 ASESINTVVEPVSVAQSPTIEDSTPEEVTQCSAVNSTDTEVASAAPIQVDQKIQPVHVELVSQIE 1924
            |:|.:....|||..|..|..|            .|...|::||           |.|.|     |
Yeast   523 ANEPVEDTSEPVEDAGEPVQE------------TNEFTTDIAS-----------PRHQE-----E 559

  Fly  1925 ASDLQESPKDTAQVESDSVDQAILTQVSETDSIVVEPSSPVKQSEDSQGEPPGS-AQNVLDVGPV 1988
            ..:|:..|||.                  |:|:.||||     :||.:.|..|| |::  |:..|
Yeast   560 DIELEAEPKDA------------------TESVAVEPS-----NEDVKPEEKGSEAED--DINNV 599

  Fly  1989 EMDQSAPEEV--PETDPVA-VEPSVPVEEEVIEVIQPAPKEI-SDSVERTLDSLGNT 2041
            ..:.::.|..  .:|:..| :|.|...||:     :....|: :|.|..|.::..||
Yeast   600 SKEAASGESTTHQKTEASASLESSAVTEEQ-----ETTEAEVNTDDVLSTKEAKKNT 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43340	NP_001246184.1	FYVE_BSN_PCLO	63..119	CDD:277290
CHS5	NP_013434.1	Chs5_N	4..76	CDD:260117	7/30 (23%)
		fn3_2	77..165	CDD:407129	23/108 (21%)
		BRCT_CHS5_like	172..255	CDD:349373	16/82 (20%)
		MDN1	<366..607	CDD:227596	87/438 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900