DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43340 and Dmp1

DIOPT Version :9

Sequence 1:	NP_001246184.1	Gene:	CG43340 / 35698	FlyBaseID:	FBgn0263077	Length:	3213	Species:	Drosophila melanogaster
Sequence 2:	NP_001345942.1	Gene:	Dmp1 / 13406	MGIID:	94910	Length:	503	Species:	Mus musculus

Alignment Length:	569	Identity:	124/569 - (21%)
Similarity:	203/569 - (35%)	Gaps:	134/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1448 ARPVSAVE--EVKPIEDSTAAIDKSP------------QISPIEGE-HSQHSE-KETPESVEVGL 1496
            |.||:...  |.:..|:.|..:..||            |.|| ||: :|.|:: .|:.|  |:|.
Mouse    16 ALPVARYHNTESESSEERTGDLAGSPPPPTNSESSEESQASP-EGQANSDHTDSSESGE--ELGY 77

  Fly  1497 DSPNVADVITTSVEVIPTSTTAVTTSDGASTEMPEPPKIYCETAPPAAEEIEQNETVETLSVSAD 1561
            |..          :..|....:.:|..||..|..|..                         |.|
Mouse    78 DRG----------QYRPAGGLSKSTGTGADKEDDEDD-------------------------SGD 107

  Fly  1562 TTLPEEIVSQDGNLEASEQTASIDVTFQANLNNMESKGCVEVAVDVRESKEDETLMEPIAVDVAV 1626
            .|..:|    |.:|...|..       ....:.::|.   |.:.|..:|.||.|..|..|.|  .
Mouse   108 DTFGDE----DNDLGPEEGQ-------WGGPSKLDSD---EDSTDTTQSSEDSTSQENSAQD--T 156

  Fly  1627 PVEVVPQCAGVELGVSEPEEATPATNNLTSGENPPEEVSELVDVEPRNPHEEIHTD--SFEKDSQ 1689
            |.:.....:..|.. |.||          :|::..:..||...|...:..|..|.|  .|:.:..
Mouse   157 PSDSKDHDSEDEAD-SRPE----------AGDSTQDSESEEQRVGGGSEGESSHGDGSEFDDEGM 210

  Fly  1690 KSSDAVALHEDNTKSEEKVDPPQV-AEEVAPDIITLDPPSLVELSPDTQAMAIGNIAPFDIILEP 1753
            :|.|..:...|  :...::....: :||...|    ..|:..:.|.|:|::...:...|     .
Mouse   211 QSDDPESTRSD--RGHARMSSAGIRSEESKGD----HEPTSTQDSDDSQSVEFSSRKSF-----R 264

  Fly  1754 ESIVIEQPVPVVKPETIVVESDPEAIDHTALLEPSVSAEVQDKVESAQQQVSENKSVEEDSLKVS 1818
            .|.|.|:.......::...|:..::.:.||..|.|.|...:|..||..|         |||
Mouse   265 RSHVSEEDYRGELTDSNSRETQSDSTEDTASKEESRSESQEDTAESQSQ---------EDS---- 316

  Fly  1819 IGERGEIISMDPITPADAVSEQNFRVEDPITSTESTAVEVIASESINTVVEPVSVAQSPTIEDST 1883
              ..|:          |..||.:....:|...:.|.:.|.:.|||...  .|.:.:|:...|||.
Mouse   317 --PEGQ----------DPSSESSEEAGEPSQESSSESQEGVTSESRGD--NPDNTSQAGDQEDSE 367

  Fly  1884 PEEVTQCSAVNSTDTEVASAAPIQVD-QKIQPVHVELVSQIEASDLQESPKDTAQVESDSVDQAI 1947
            ..|....:..:|::::   :...|.| :..:.:.:...||..|.|...|.::..|.:|.|.:...
Mouse   368 SSEEDSLNTFSSSESQ---STEEQADSESNESLSLSEESQESAQDGDSSSQEGLQSQSASTESRS 429

  Fly  1948 LTQVSETDSIVVE-----PSSPVKQSEDSQGEPPGSAQNVLDVGPVEMD 1991
            ....||.||...|     .||..|:..:|.|....|.:   |:.|..|:
Mouse   430 QESQSEQDSRSEEDSDSQDSSRSKEESNSTGSASSSEE---DIRPKNME 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43340	NP_001246184.1	FYVE_BSN_PCLO	63..119	CDD:277290
Dmp1	NP_001345942.1	DMP1	1..503	CDD:311295	124/569 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..503		121/562 (22%)
		Cell attachment site. /evidence=ECO:0000255	350..352		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900