DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1358 and SLC49A4

DIOPT Version :9

Sequence 1:	NP_001188873.1	Gene:	CG1358 / 35697	FlyBaseID:	FBgn0033196	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_116228.1	Gene:	SLC49A4 / 84925	HGNCID:	16628	Length:	478	Species:	Homo sapiens

Alignment Length:	444	Identity:	120/444 - (27%)
Similarity:	207/444 - (46%)	Gaps:	59/444 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWTSMIYMILYIPL- 109
            |..| :||.|||.||:||...:....:.|..:..|.|...:.||.|    .| .:..::|:.|:
Human    42 PGPG-RVYGRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFS----SW-DIALLVLWGPIG 100

  Fly   110 ---IFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFI--GQSIVALAQVCILSL 169
               .|...|.|||.|||||.|:......:|..::...:...:.....|  ||.:..||...:::.
Human   101 FLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILKRRLIHGGQMLNGLAGPTVMNA 165

  Fly   170 PARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVP----NSPDLETVGS------DLQM 224
            ...|:..||..|:.::||::....:.||.|..|::.|::||    .||.|....|      .::.
Human   166 APFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEA 230

  Fly   225 MFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESSEAEQVSFMQSLKNLMTNRNFIFLL 289
            :.|...|:..::....:.:|..:||.|||.|         :.::::|:.:|:..|::|..|:.:.
Human   231 VLYAEFGVVCLIFSATLAYFPPRPPLPPSVA---------AASQRLSYRRSVCRLLSNFRFLMIA 286

  Fly   290 LSYGINVGVFYAISTLLNPVVLKYYPGH--EVDAGRIGL-SIVLAGMLGSVVSGIVLDKTHKFKE 351
            |:|.|.:|||...|.:|:.::.   |.|  :||||.||. |||     |..|.||.:.:...|..
Human   287 LAYAIPLGVFAGWSGVLDLILT---PAHVSQVDAGWIGFWSIV-----GGCVVGIAMARFADFIR 343

  Fly   352 TTLAVYAL------SMVGMWIFTFTL--DTGHI----AVVYLTASLLGFFMTGYLPVGFEFGAEL 404
            ..|.:..|      ::...| ||.|.  ...|:    ..:|.:..|||.|:...:|:.||...|.
Human   344 GMLKLILLLLFSGATLSSTW-FTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVET 407

  Fly   405 TFPEPEGTSSGLLNASAQTF-GIC---FTLFYSELFTTFGDIAANITMAVMLIV 454
            .:|.|||.:.|::...:..| |:.   .|.:::||......:..:..::::||:
Human   408 VYPVPEGITCGVVTFLSNMFMGVLLFFLTFYHTELSWFNWCLPGSCLLSLLLIL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1358	NP_001188873.1	MFS_1	62..422	CDD:284993	104/390 (27%)
CG1358	NP_001188873.1	MFS	63..461	CDD:119392	110/427 (26%)
SLC49A4	NP_116228.1	Mediates lysosomal localization	14..15
		MFS	66..449	CDD:119392	107/405 (26%)
		MFS_1	69..425	CDD:284993	102/378 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54923
OrthoDB	1	1.010	-	-		D702737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830