DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1358 and FLVCR2

DIOPT Version :9

Sequence 1:	NP_001188873.1	Gene:	CG1358 / 35697	FlyBaseID:	FBgn0033196	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_060261.2	Gene:	FLVCR2 / 55640	HGNCID:	20105	Length:	526	Species:	Homo sapiens

Alignment Length:	438	Identity:	224/438 - (51%)
Similarity:	315/438 - (71%)	Gaps:	9/438 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AGGHNPPAEG------YKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISDKWVDWT 98
            :|..:|.:.|      .||..|||||:::|..||..|:.|||||..||||...:||:|...:||.
Human    62 SGLAHPSSSGPEDLSVIKVSRRRWAVVLVFSCYSMCNSFQWIQYGSINNIFMHFYGVSAFAIDWL 126

  Fly    99 SMIYMILYIPLIFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSFIGQSIVALAQ 163
            ||.||:.||||:.|.:|.|:|.|||..||.|....|:|||:|:.|:.|.||.|:.:||.|.::||
Human   127 SMCYMLTYIPLLLPVAWLLEKFGLRTIALTGSALNCLGAWVKLGSLKPHLFPVTVVGQLICSVAQ 191

  Fly   164 VCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVPNSPDLETVGSDLQMMFYL 228
            |.||.:|:|:|:||||.::||:|.||.|||||||:|:||::||:||||..|.:.:...:.:|||:
Human   192 VFILGMPSRIASVWFGANEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIEDRDELAYHISIMFYI 256

  Fly   229 VAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESSEAEQVSFMQSLKNLMTNRNFIFLLLSYG 293
            :.|:.::||:|::|.|::||..|||.||..:..|.|.:|   |::.|:..|..|.||:.|:::||
Human   257 IGGVATLLLILVIIVFKEKPKYPPSRAQSLSYALTSPDA---SYLGSIARLFKNLNFVLLVITYG 318

  Fly   294 INVGVFYAISTLLNPVVLKYYPGHEVDAGRIGLSIVLAGMLGSVVSGIVLDKTHKFKETTLAVYA 358
            :|.|.|||:|||||.:|:.:|||.||:||||||:||:|||||:|:|||.||::..:|||||.||.
Human   319 LNAGAFYALSTLLNRMVIWHYPGEEVNAGRIGLTIVIAGMLGAVISGIWLDRSKTYKETTLVVYI 383

  Fly   359 LSMVGMWIFTFTLDTGHIAVVYLTASLLGFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQT 423
            :::|||.::||||:.||:.||::||..:|||||||||:||||..|||:||.||.||||||.|||.
Human   384 MTLVGMVVYTFTLNLGHLWVVFITAGTMGFFMTGYLPLGFEFAVELTYPESEGISSGLLNISAQV 448

  Fly   424 FGICFTLFYSELFTTFGDIAANITMAVMLIVGTIITAITQSDLRRQNA 471
            |||.||:...::...:|....||.:.|.|.:|..:||..::|||||.|
Human   449 FGIIFTISQGQIIDNYGTKPGNIFLCVFLTLGAALTAFIKADLRRQKA 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1358	NP_001188873.1	MFS_1	62..422	CDD:284993	193/359 (54%)
CG1358	NP_001188873.1	MFS	63..461	CDD:119392	207/397 (52%)
FLVCR2	NP_060261.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		2/7 (29%)
		8 X 6 AA tandem repeats of P-S-[VS]-S-[VIAG]-[HNP]	25..72		2/9 (22%)
		MFS	88..488	CDD:119392	208/402 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..526
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147037
Domainoid	1	1.000	417	1.000	Domainoid score	I651
eggNOG	1	0.900	-	-		E1_KOG2563
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1551
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54923
OrthoDB	1	1.010	-	-		D425075at33208
OrthoFinder	1	1.000	-	-		FOG0002624
OrthoInspector	1	1.000	-	-		otm40897
orthoMCL	1	0.900	-	-		OOG6_100662
Panther	1	1.100	-	-	LDO	PTHR10924
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2905
SonicParanoid	1	1.000	-	-		X1725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800