DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1358 and Slc49a4

DIOPT Version :9

Sequence 1:	NP_001188873.1	Gene:	CG1358 / 35697	FlyBaseID:	FBgn0033196	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001012017.1	Gene:	Slc49a4 / 303902	RGDID:	1310939	Length:	478	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	120/462 - (25%)
Similarity:	213/462 - (46%)	Gaps:	62/462 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TPKEKEGKGLKVAGGHNPPAEGYKVYARRWAVLILFVFYSSSNAMQWIQYTIINNIITRYYGISD 92
            |.:.:|...:..|.|.:|.    :||.|||.||:||...:.:..:.|..:..|.|...:.|
  Rat    27 TRRGREAAAVLPAAGPSPG----RVYGRRWLVLLLFSLLAFAQGLVWNTWGPIQNSARQAY---- 83

  Fly    93 KWVDWTSMIYMILYIPL----IFPGSWFLDKVGLRITALVGIVGTCVGAWIKVFSVDPSLFYVSF 153
            .:..| .:..::|:.|:    .|...|.|||.|||||.|:......:|..::...|.........
  Rat    84 SFTGW-DIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPVSDLTLKKRL 147

  Fly   154 I--GQSIVALAQVCILSLPARLAAVWFGPDQVSSATSVGVFGNQLGVAVGFVLPPMLVP----NS 212
            |  ||.:..||...:::....|:..||..|:.::||::....:.||.|..|::.|::||    .:
  Rat   148 IHGGQILNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTA 212

  Fly   213 PDL------ETVGSDLQMMFYLVAGLTSILLVLMVIFFQDKPPTPPSAAQEAAQLLESSEAEQVS 271
            |.|      :.:...::.:.|...|:..::....:.:|..:||.|||.|         :.::::|
  Rat   213 PLLTAESSRDHIKDRIETVLYAEFGVVCLIFSATLAYFPPRPPLPPSVA---------AASQRLS 268

  Fly   272 FMQSLKNLMTNRNFIFLLLSYGINVGVFYAISTLLNPVVLKYYPGH--EVDAGRIGL-SIVLAGM 333
            :.:|...|::|..|:.:.|:|.|.:|||...|.:|:.::.   |.|  :||||.||. |||
  Rat   269 YRRSFCRLLSNLRFLMIALAYAIPLGVFAGWSGVLDLILT---PVHVSQVDAGWIGFWSIV---- 326

  Fly   334 LGSVVSGIVLDKTHKFKETTLAVYAL------SMVGMWIFTFTL--DTGHI----AVVYLTASLL 386
             |..|.||.:.:...|....|.:..|      ::...| ||.|.  ...|:    ..:|.:..||
  Rat   327 -GGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTW-FTLTCLNSVTHLPLTTVTLYASCILL 389

  Fly   387 GFFMTGYLPVGFEFGAELTFPEPEGTSSGLLNASAQTF-GICF---TLFYSELFTTFGDIAANIT 447
            |.|:...:|:.||...|..:|.|||.:.|::...:..| |:..   |.:::||......:..:..
  Rat   390 GVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFVTFYHTELSWFNWCLPGSCL 454

  Fly   448 MAVMLIV 454
            ::::||:
  Rat   455 LSLLLIL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1358	NP_001188873.1	MFS_1	62..422	CDD:284993	101/390 (26%)
CG1358	NP_001188873.1	MFS	63..461	CDD:119392	107/427 (25%)
Slc49a4	NP_001012017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		120/462 (26%)
		Mediates lysosomal localization. /evidence=ECO:0000250	14..15
		MFS	66..449	CDD:119392	104/405 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2563
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54923
OrthoDB	1	1.010	-	-		D702737at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830