DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scra and Anln

DIOPT Version :9

Sequence 1:	NP_724582.1	Gene:	scra / 35696	FlyBaseID:	FBgn0261385	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	XP_006510644.1	Gene:	Anln / 68743	MGIID:	1920174	Length:	1139	Species:	Mus musculus

Alignment Length:	1345	Identity:	331/1345 - (24%)
Similarity:	528/1345 - (39%)	Gaps:	328/1345 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDPFTQHMLEKAEQRSRALGISNASKFPLVECSVPSSSATSASGGDAGVLAPRSRSPGGQSAASG 65
            |||||:.:||:...|...|....|.:        |::.|.||.....| ..|.|.:...|....|
Mouse     1 MDPFTEKLLERTRARRENLQRKMAER--------PTAVARSAPHAKRG-REPLSEASNQQQPLPG 56

  Fly    66 GGKVVTLGKATLEASPAKPLRHYTAVNKENLDMGIEINITTDKPIGVQVEIQEQEVTDDEEQAEG 130
            |.:     |:..:.||:|..      ..:.:::|.. ::...:||.|.........   ..||:.
Mouse    57 GEE-----KSCTKPSPSKKR------CSDKIEVGAP-DLENTEPIDVAKPCSPMPA---PRQAKP 106

  Fly   131 GALNPLLEAEPVNQPLARL--------------RDTSRSRLQRMGALYSNTD-DLSSPIHRTEGQ 180
            .|  |...:|.|..|.|.|              ..:.::|:||:.....:.| ||:..:  :|..
Mouse   107 PA--PAAISESVAAPAALLSADRGLNSGSEASATSSVKTRMQRLAEQRRHWDSDLTDDV--SESS 167

  Fly   181 FHVTTGEEEDCGNRS-------SRQPKQRLGKLAALADTINQWEDDTSHHEVHRLLEAPPPKPHL 238
            :......|:...:.|       |..|..|.|:||.||.||..||||.||....:
Mouse   168 YFAPVPTEDKAASPSKPPISNASATPVGRRGRLANLAATICSWEDDVSHSSAKQ----------- 221

  Fly   239 SSRRAEKGPAPLPPKKDEVDEAS---RTKQLKWDPKVLSSLEAQGFQRRE-SSTIKHTYDYAKQE 299
            :|.:.:.|.|.| .|......||   .:..::.:....|..:.....|:: ||...|
Mouse   222 NSVQEQPGTACL-SKSSSASGASASINSSSVQQEATCCSPRDGNASVRKDPSSNAAH-------- 277

  Fly   300 EAAP--ASKVEDAVLTAKPPVPQKSTTVSQVAKN----FASSAP----APKPAPAPAVSVKSGLV 354
              .|  ::.|..:|..:.|.......|.::.|:|    ..:::|    |.||...|.:|
Mouse   278 --GPLLSASVSSSVKASSPVTAATFITENREAQNPELLHKTASPLKTEARKPCEKPTLS------ 334

  Fly   355 SGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGNNKAMLPMAPIGSAPSITQIRAEEV 419
                       .|.|.:...| ::.| |..:.:.||...|..         |..|.:.:. .|..
Mouse   335 -----------QGAQPKEEAN-REVC-LQSQSKDKLATPGGR---------GIKPFLERF-GERC 376

  Fly   420 KQHLAAMHPVTAAAAT-TVVAATKPKQENKLRDKVAALVANAQSSAETRIKDIDRQRQEDMQIIS 483
            ::|........|:..| .:...||..||...:.       |..||.....:.:.::|::::..:.
Mouse   377 QEHSKESPSYRASHKTPNITPNTKAIQERLFKQ-------NTCSSTTHLAQQLKQEREKELACLR 434

  Fly   484 NRFNK---------QKELFDNQPSDSSVAAQARPPAPAPSRVVRPMPPPPPPPIAALSPGLASSK 539
            .|.:|         :|....:..:...|..|..|                            ..|
Mouse   435 GRLDKGNLWSAEKNEKSRSKHLETKQEVHCQNTP----------------------------LKK 471

  Fly   540 RRSPGDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCCAAETASATDDSHQQDEEETESCMDE 604
            .::....|.|....|                         .||...|...|..:....|||.|.:
Mouse   472 HQTVASTPLTSVTDK-------------------------VAENEPAVKLSSTEPAGSTESEMTK 511

  Fly   605 SDDQSQT----EDSSAGMCNGSLGREIMSAVQRNEVEMQQQQTGKKTVRYADQDMYYDDSSLNSS 665
            |.....|    |:.|..:.              :::|::|.....:.|     :|..||..:|||
Mouse   512 SSPLKITLFLEEEKSLKVA--------------SDLEVEQNTEAVREV-----EMSVDDEDINSS 557

  Fly   666 QVSAGIDDYLDEALVE---DYGSTQDDQSDSG---DEQNASRLSLGSKGTTA-----------SN 713
            :|   |:|...:.|.|   |...:|::....|   .|:....|::.|....|           .|
Mouse   558 RV---INDIFSDVLEEGELDVEKSQEEMDQVGAENSEEQEDALNISSMSLLAPLAQTVGVVSLEN 619

  Fly   714 SFSFRKNPASICTPIEEHHEMEMDLQTPLLSGAQPVKSELSVNQDNDNLVTLVHTVSFYR----R 774
            ..|   :|.|             :|:...||.|.|...:                  |.|    |
Mouse   620 VIS---SPPS-------------ELRDSNLSAASPKPGK------------------FQRTRVPR 650

  Fly   775 QQSANSSNSTPVRKICREQQVMRSALAGDCHAKHRL-EYDSPQQSDYVAAATDIADQTDEDDEEM 838
            .:||:|..|       .::.::.|.   |.:...|. |.:.|.....:....|:..:..|.....
Mouse   651 AESADSLGS-------EDRDLLYSI---DAYRSQRFKETERPSIKQVIVRKEDVTSKLGEKKNVF 705

  Fly   839 QNAREVNDASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLLLATHR 903
            ..  :||    .:.|:::|.:::..||.||.|||||||.|.......||.|..|.||.||:||.:
Mouse   706 SG--QVN----IKQKMQELNNDINLQQTVIYQASQALNCCVDEEHGKGSLEEAEAERLLLIATEK 764

  Fly   904 RQACLDEVQRLRVE-----NSIRPVG----APKEKGLLTVKDITIPLRQEYVRKMA--SNNINGH 957
            |...:||:.:|:.|     |....:.    || .||.:|:.:|.:||:.::|...|  ::..|.:
Mouse   765 RALLIDELNKLKSEGPQRRNKTSVISQSEFAP-SKGSVTLSEICLPLKADFVCSTAQKTDASNYY 828

  Fly   958 HLVCLLKYNEHVLATKTVPTMPGLL--SVKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELK 1020
            :|:.|....|.::||....|...|.  ::.||....|::|..||.|.:|:|.::.::|.|..:.|
Mouse   829 YLIMLKAGAEQMVATPLASTANSLSGDALTFPTTFTLHDVSNDFEINIEVYSLVQKKDSLGPDKK 893

  Fly  1021 YHINLNKKGGIKTPKK-------KGGENRLVMPPVQSPAGPHVVRTPQLVQYGFAIFSLREIQRT 1078
            ...:.:|   ..|||:       |...:..||   .||.|...|||......|....||..:..|
Mouse   894 KKASKSK---AITPKRLLTSITSKSSLHSSVM---ASPGGLGAVRTSNFTLVGSHTLSLSSVGDT 952

  Fly  1079 TWTLTQV---------LG---------VSPLEGVVHMKVNCELSVSVEYKGFLTMFEDISGFGAW 1125
            .:.|.::         ||         :|||||.:.:|::|:::.:||.|||||:|||:||||||
Mouse   953 KFALDKINFDVREQELLGYLFQEKVPFLSPLEGHICLKISCQVNSAVEEKGFLTIFEDVSGFGAW 1017

  Fly  1126 HRRWCYLNGSVINYWKYPDDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTMLLECERPALET 1190
            |||||.|:|:.|:||.|||||:||.|:|.|:|.:|.|.::..|.|:.|||.||:.|...||..|.
Mouse  1018 HRRWCVLSGNCISYWTYPDDERRKNPIGRINLANCISHQIEPANREFCARRNTLELITVRPQRED 1082

  Fly  1191 DQESLIIVPNGRTTTVRHLLSADTKEEREEWCAYLNKALTLLRAW 1235
            |:|:|:..........::.|||||||||:.|...||:.:..:|.|
Mouse  1083 DRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVIVDIRLW 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637	25/81 (31%)
		Anillin	929..1076	CDD:285397	44/157 (28%)
		PH_anillin	1106..1233	CDD:269964	65/126 (52%)
		PH	1107..1229	CDD:278594	65/121 (54%)
Anln	XP_006510644.1	PHA03307	24..>206	CDD:223039	45/209 (22%)
		Anillin_N	141..227	CDD:374301	26/98 (27%)
		Anillin_N	423..488	CDD:374301	11/117 (9%)
		Anillin	797..950	CDD:369734	44/158 (28%)
		PH_anillin	999..1125	CDD:269964	65/125 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837705
Domainoid	1	1.000	139	1.000	Domainoid score	I4794
eggNOG	1	0.900	-	-		E1_KOG3640
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2699
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003560
OrthoInspector	1	1.000	-	-		oto91885
orthoMCL	1	0.900	-	-		OOG6_106902
Panther	1	1.100	-	-	LDO	PTHR21538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2397
SonicParanoid	1	1.000	-	-		X4027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780