DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scra and RTKN

DIOPT Version :9

Sequence 1:	NP_724582.1	Gene:	scra / 35696	FlyBaseID:	FBgn0261385	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_001015055.1	Gene:	RTKN / 6242	HGNCID:	10466	Length:	563	Species:	Homo sapiens

Alignment Length:	474	Identity:	95/474 - (20%)
Similarity:	168/474 - (35%)	Gaps:	161/474 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 DDEEMQNAREVNDASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLL 898
            :|.|:|  |:::...:.::...|||: .|.|::                      :::|..:.||
Human    37 EDTELQ--RKLDHEIRMREGACKLLA-ACSQRE----------------------QALEATKSLL 76

  Fly   899 LATHRRQACLDEVQRLRV-----ENSIRP--VGAPKE----KGLLTVKDITIPLR---QEYVRKM 949
            :...|..:.:.|:||.:.     :.|.||  .|.|.|    :|.:.:.|:.|||.   .||.:.
Human    77 VCNSRILSYMGELQRRKEAQVLGKTSRRPSDSGPPAERSPCRGRVCISDLRIPLMWKDTEYFKN- 140

  Fly   950 ASNNINGHHLVCLLKYNEHVLATKTVPTMPGLLSVKFPDVLQLNNVYA----DFRITLEIYGMLA 1010
             ..:::...:..||:..||:..|:.:.....|..:.|    |.|.::|    ||.:.||:||...
Human   141 -KGDLHRWAVFLLLQLGEHIQDTEMILVDRTLTDISF----QSNVLFAEAGPDFELRLELYGACV 200

  Fly  1011 QRD------------QLPHEL------KYHINLNKKGGIKTPKKKGGENRLVMP-PVQSPAGP-- 1054
            :.:            :|...|      :...:|:..||       .|.:.:::| ||  ..||
Human   201 EEEGALTGGPKRLATKLSSSLGRSSGRRVRASLDSAGG-------SGSSPILLPTPV--VGGPRY 256

  Fly  1055 ----HVVRTPQLVQYGFAIFSL---REIQRTTWTLTQVLGVSPLEGVVHMKVNCEL--------- 1103
                |...|...||.||....|   ...:...|.        ||.|    .|.|.|
Human   257 HLLAHTTLTLAAVQDGFRTHDLTLASHEENPAWL--------PLYG----SVCCRLAAQPLCMTQ 309

  Fly  1104 -----SVSVEYKGFLTMFEDISGFGAWHRRWCYLNGSVINYWKYPDD-EKRKTPMGSIDLNSCTS 1162
                 ::.|:..|.:..:..:.|         .|.|:.:..::.|:| :..:.|:.:|.:|..|.
Human   310 PTASGTLRVQQAGEMQNWAQVHG---------VLKGTNLFCYRQPEDADTGEEPLLTIAVNKETR 365

  Fly  1163 QKVTTAPRDICARLNTMLLECERPALETDQESLIIVPNGRTTT-----------VRHLLSADTKE 1216
            .:                      |.|.||..      ||..|           |.|.|..:::|
Human   366 VR----------------------AGELDQAL------GRPFTLSISNQYGDDEVTHTLQTESRE 402

  Fly  1217 EREEWCAYLNKALTLLRAW 1235
            ..:.|...|.:....:..|
Human   403 ALQSWMEALWQLFFDMSQW 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637
		Anillin	929..1076	CDD:285397	41/181 (23%)
		PH_anillin	1106..1233	CDD:269964	24/138 (17%)
		PH	1107..1229	CDD:278594	24/133 (18%)
RTKN	NP_001015055.1	Hr1	37..91	CDD:128981	14/78 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..116		6/19 (32%)
		Anillin	117..267	CDD:311895	36/164 (22%)
		PH_rhotekin2	309..419	CDD:270069	24/146 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910