DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scra and si:dkey-30c15.10

DIOPT Version :9

Sequence 1:	NP_724582.1	Gene:	scra / 35696	FlyBaseID:	FBgn0261385	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_001352786.1	Gene:	si:dkey-30c15.10 / 559353	ZFINID:	ZDB-GENE-060503-826	Length:	948	Species:	Danio rerio

Alignment Length:	1068	Identity:	237/1068 - (22%)
Similarity:	415/1068 - (38%)	Gaps:	253/1068 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 LKWDPKVLSSLEAQGFQRRESSTIKHTYDYAKQEEAAPASKVEDAVLTAKPPVPQKSTTVSQVAK 330
            |:.:|...|.||         :.:|      |:..||...:.:|         |.||.|.|::..
Zfish    11 LEENPSASSELE---------NVLK------KRRLAAGGEENQD---------PSKSPTRSRLRM 51

  Fly   331 NFASSAPAPKPAPAPAVSVKSGLVSGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGN 395
            ......|     ..||::    .:..|......:..||.....|...||              |:
Zfish    52 TELEMKP-----DTPAIA----SIHSRVQQLSQRREGGTGLVQRCLSDP--------------GS 93

  Fly   396 NKAMLPMAPIGSAPSITQI-----------RAEEVKQHLAAMHPVTAAAATTVVAATKPKQENKL 449
            :          ..||:|.:           |.|..|    |..|:.:...:|..:.:.....:.:
Zfish    94 D----------DCPSMTSVISHIGEGEFSSRLERFK----APTPMNSPGRSTPCSRSLSSFVHGM 144

  Fly   450 RDKVAALVANAQSSAETRIKDIDRQRQEDMQIISNRFNKQKELFDNQPSDSSVAAQARPPAPAP- 513
            :.|:.|.|..:...| :||:   :.|:::::::..:...:...|....||||:..:|.|...:|
Zfish   145 QQKLNATVTPSSKEA-SRIR---QAREDELRLLKIQPVAENMWFKRSLSDSSLTERASPSTSSPW 205

  Fly   514 --SRVVRPMPPPPPPPIAALSPGLASSKRRS----PGDAPTTDEDSKRARKSHSDRLYP------ 566
              .::::|..||       |.||....|...    .||:...|..........|:..:|
Zfish   206 VYRKILKPQWPP-------LQPGSEELKGNEFTSCEGDSKVFDGSLNTTPPCTSNIRFPNEELYT 263

  Fly   567 ------ALSD---LDSSGDNCC--AAETASATDDSHQQDEEETESCMDESDDQSQTEDSSAGMCN 620
                  |||.   :|...::..  |.:...|.|::.|::.|:.|||:      |||||.:
Zfish   264 SVAEPGALSTSALIDKMFEDVLQHAEKEDEAADENKQEEMEKAESCV------SQTEDKT----- 317

  Fly   621 GSLGREIMSAVQRNEVEM----QQQQTGKKTVRYADQDMYYDDSSLNSSQVSAGIDDYLDEALVE 681
                 |:.:....:|.|:    .::.|...||:..|:...  |:..|..:....|.:..|:..:.
Zfish   318 -----ELDTVENEDETELDTVENEENTQWHTVKNEDETEL--DTVKNEDKTELNIVENEDKTKLN 375

  Fly   682 DYGSTQDDQSDSGDEQNASRLSLGS-------------KGTTASNSFSFRKNPASICTPIEEHHE 733
            ......:.|.|:.:|:....:::..             :....|::.|..|........:||..|
Zfish   376 IVEKEDNTQQDAVEEEKVESVTINEELLDHSEMSEESVESPDDSSAVSKEKELQDGEGEMEEEQE 440

  Fly   734 -----MEMDLQT--------PLLSGAQ----PVKSELSVNQDNDNL-------------VTLVHT 768
                 .|.|..|        ||....:    |:|.|:::::.:|.|             |..:::
Zfish   441 CPPMGAEDDFLTLPPSYILSPLSKSVEAVVTPLKIEITLSEPSDQLPLPEEVTDGSADSVPPLYS 505

  Fly   769 VSFYRRQQSANSSNSTPVRKICREQQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIADQTDE 833
            :..||.|           ||:                  |:|...|        ....:..|.
Zfish   506 IDAYRSQ-----------RKV------------------HQLTTQS--------LTPGVQKQV-- 531

  Fly   834 DDEEMQNAREVNDASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLL 898
             .|::.:.:.:|    .:::||.|..|..|.|.:|.|..|||:.|:......||.:..|.|:.||
Zfish   532 -QEKICSKKPIN----VKERIKALNEEAAKLQTIITQTLQALSCCSDEEHGKGSQQEAEAEKLLL 591

  Fly   899 LATHRRQACLDEVQRLRVENSIRP--VGAPKE--KGLLTVKDITIPLRQEYVRKMASNNINGHHL 959
            :::.:|.|.|.||.|||......|  ..||.:  :|.:::..|.:||:.|:|.. |......|:.
Zfish   592 VSSEKRAALLAEVNRLREGEPGEPESQNAPLQPCRGTVSISSIQLPLKVEFVCS-ARTGRPRHYF 655

  Fly   960 VCLLKYNE-HVLAT--KTVPTMPGLLSVKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELKY 1021
            ..|::|.. :::||  .|........::.||..:.|.::.:.|.|.:|:|.:...:.........
Zfish   656 FVLIRYGPCNIMATPLATAADAQNGDTITFPTSITLQDIRSSFEIDVEVYSLSNTQSNTCSLNVQ 720

  Fly  1022 HINLNKKGGIKTPKK------KGGEN--RLVMPPVQSPAGPHVVRTPQLVQYGFAIFSLREIQRT 1078
            ....:.|..: ||||      |..::  ...:|.:.:.      |:......|....:|..:.::
Zfish   721 QFRSSTKSRV-TPKKILHSITKSNQSATSATLPCLTAQ------RSSNFTLVGSHKITLNSLGQS 778

  Fly  1079 TWTLTQVLGVSPLEGVVHMKVNCELSVSVEYKGFLTMFEDISGFGAWHRRWCYLNGSVINYWKYP 1143
            .:.|.:|..:|||||.::::::.|...:|:::||||||||:||||||.|.:..|.|..:.||.||
Zfish   779 KFPLDKVPFLSPLEGHIYLRLHSEGHSNVQHEGFLTMFEDVSGFGAWQRFYFLLEGGHLLYWNYP 843

  Fly  1144 DDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTM-LLECERPALETDQESLIIVPNGRTTTVR 1207
            ::...|...||:.|....|  |....|:.|||.:|. |:|......|..|           |..:
Zfish   844 NEMGSKPADGSLSLYGFCS--VRPVERECCARPHTFELVETSTFQKEDSQ-----------TLKK 895

  Fly  1208 HLLSADTKEEREEWCAYLNKALTLLRAW 1235
            ...||||:|||.:|...||:.|.....|
Zfish   896 CWFSADTREERSDWMEKLNQTLLDFLTW 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637
		Anillin	929..1076	CDD:285397	30/157 (19%)
		PH_anillin	1106..1233	CDD:269964	49/127 (39%)
		PH	1107..1229	CDD:278594	48/122 (39%)
si:dkey-30c15.10	NP_001352786.1	DnaJ	<282..401	CDD:333066	27/136 (20%)
		Anillin	625..773	CDD:311895	29/155 (19%)
		PH_anillin	807..919	CDD:269964	49/124 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581435
Domainoid	1	1.000	62	1.000	Domainoid score	I10351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003560
OrthoInspector	1	1.000	-	-		otm24344
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21538
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.030