Protein Alignment scra and ANLN

DIOPT Version :9

• Sequence 1: NP_724582.1
• Gene: scra / 35696
• FlyBaseID: FBgn0261385
• Length: 1239
• Species: Drosophila melanogaster
• Sequence 2: XP_006715809.1
• Gene: ANLN / 54443
• HGNCID: 14082
• Length: 1142
• Species: Homo sapiens
• Alignment Length: 1356
• Identity: 343/1356 - (25%)
• Similarity: 532/1356 - (39%)
• Gaps: 347/1356 - (25%)

  Fly     1 MDPFTQHMLEKAEQRSRALGISNASKFPLVECSVPSSSATSASGGDAGVLAPRSRSP----GGQS 61
            |||||:.:||:...|...|....|.:        |:::..|.:.      |.|:|.|    ..|.
Human     1 MDPFTEKLLERTRARRENLQRKMAER--------PTAAPRSMTH------AKRARQPLSEASNQQ 51

  Fly    62 AASGGGKVVTLGKATLEASPAKP-LRHYTAVNKENLDMGIEINITTDK-----PIGVQVEIQEQE 120
            ..|||.:     |:..:.||:|. ....|.|...||:....:..|:.|     |:..||:.|..:
Human    52 PLSGGEE-----KSCTKPSPSKKRCSDNTEVEVSNLENKQPVESTSAKSCSPSPVSPQVQPQAAD 111

  Fly   121 VTDDEEQAEGG------ALNPLLEAEPVNQPLARLRDTSRSRLQRMGALYSNTDDLSSPIHRTEG 179
            ...|.......      .||..|||...:....|::..:..|.:     :.| ||::..|..: .
Human   112 TISDSVAVPASLLGMRRGLNSRLEATAASSVKTRMQKLAEQRRR-----WDN-DDMTDDIPES-S 169

  Fly   180 QFHVTTGEEEDCG------NRSSRQPKQRLGKLAALADTINQWEDDTSHHEVHRLLEAPPPKPHL 238
            .|.....||:...      :.:|..|..|.|:||.||.||..||||.:|...
Human   170 LFSPMPSEEKAASPPRPLLSNASATPVGRRGRLANLAATICSWEDDVNHSFA------------- 221

  Fly   239 SSRRAEKGPAPLPPKKDEVDEASRTKQLKWDPKVLSSLEAQGFQRRESSTIKHTYDYAKQEEA-- 301
                          |::.|.|...|..|.   |..|:..|..  |..||::|....:..|.:.
Human   222 --------------KQNSVQEQPGTACLS---KFSSASGASA--RINSSSVKQEATFCSQRDGDA 267

  Fly   302 ----APASKVEDAVL-------TAKPPVPQKSTTVSQVAKNFASSAP--APKPAPAP---AVS-- 348
                |.:|..:||.|       :.|...|.||||....||:.....|  .||...:|   .||
Human   268 SLNKALSSSADDASLVNASISSSVKATSPVKSTTSITDAKSCEGQNPELLPKTPISPLKTGVSKP 332

  Fly   349 -VKSGLVSGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGNNKAMLPMAPIGSAPSIT 412
             |||.|                     :|..|.:..|...:.|.....:|:..| ...|..|.:.
Human   333 IVKSTL---------------------SQTVPSKGELSREICLQSQSKDKSTTP-GGTGIKPFLE 375

  Fly   413 QIRAEEVKQHLAAMHPVTAAAATTVVAA-TKPKQENKLRDKVAALVANAQSSAETRI-KDIDRQR 475
            :. .|..::|.......:....|.::.. ||..||.        |.....||:.|.: :.:.::|
Human   376 RF-GERCQEHSKESPARSTPHRTPIITPNTKAIQER--------LFKQDTSSSTTHLAQQLKQER 431

  Fly   476 QEDMQIISNRF-------------NKQKELFDNQPSDSSVAAQARPPAPAPSRVVRPMPPPPPPP 527
            |:::..:..||             :|.|:|...|.:.    .|:.|
Human   432 QKELACLRGRFDKGNIWSAEKGGNSKSKQLETKQETH----CQSTP------------------- 473

  Fly   528 IAALSPGLASSKRRSPGDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCCAAETASATDDSHQ 592
               |......||.:|   .|.|::                            ..|......:|..
Human   474 ---LKKHQGVSKTQS---LPVTEK----------------------------VTENQIPAKNSST 504

  Fly   593 QDEEETESCMDESDDQSQT----EDSSAGMCNGSLGREIMSAVQRNEVEMQQQQTGKKTVRYADQ 653
            :.:..||..|.:|.....|    ||.|..:.:.....:.:..::  |:||.
Human   505 EPKGFTECEMTKSSPLKITLFLEEDKSLKVTSDPKVEQKIEVIR--EIEMS-------------- 553

  Fly   654 DMYYDDSSLNSSQVSAGIDDYLDEALVE---DYGSTQDDQ----SDSGDEQ----NASRLSL--- 704
               .||..:|||:|   |:|...:.|.|   |...:|::.    ::|.:||    |.|.:||
Human   554 ---VDDDDINSSKV---INDLFSDVLEEGELDMEKSQEEMDQALAESSEEQEDALNISSMSLLAP 612

  Fly   705 --GSKGTTASNSFSFRKNPASICTPIEEHHEMEMDLQTPLLSGAQPVKSELSVNQDNDNLVT--- 764
              .:.|..:..|.        :.||..|..:.....::|.....|  ::.:...:..|:|.:
Human   613 LAQTVGVVSPESL--------VSTPRLELKDTSRSDESPKPGKFQ--RTRVPRAESGDSLGSEDR 667

  Fly   765 -LVHTVSFYRRQQSANSSNSTPVRKICREQQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIA 828
             |::::..||.|:..                                |.:.|.....:....|:.
Human   668 DLLYSIDAYRSQRFK--------------------------------ETERPSIKQVIVRKEDVT 700

  Fly   829 DQTDEDDEEMQNAREVNDASQAQ----DKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTE 889
            .:.||.          |:|...|    .|:::|.:|:..||.||.|||||||.|.......||.|
Human   701 SKLDEK----------NNAFPCQVNIKQKMQELNNEINMQQTVIYQASQALNCCVDEEHGKGSLE 755

  Fly   890 SVEGERYLLLATHRRQACLDEVQRLRVENSIRPVGAPKE------KGLLTVKDITIPLRQEYVRK 948
            ..|.||.||:||.:|...:||:.:|:.|...|...|..:      ||.:|:.:|.:||:.::|..
Human   756 EAEAERLLLIATGKRTLLIDELNKLKNEGPQRKNKASPQSEFMPSKGSVTLSEIRLPLKADFVCS 820

  Fly   949 MAS--NNINGHHLVCLLKYNEHVLATKTVPTMPGLL--SVKFPDVLQLNNVYADFRITLEIYGML 1009
            ...  :..|.::|:.|....|:::||....|...|.  ::.|.....|.:|..||.|.:|:|.::
Human   821 TVQKPDAANYYYLIILKAGAENMVATPLASTSNSLNGDALTFTTTFTLQDVSNDFEINIEVYSLV 885

  Fly  1010 AQRDQLPHELKYHINLNKKGGIKTPKK-------KGGENRLVMPPVQSPAGPHVVRTPQLVQYGF 1067
            .::|  |..|......:|...| |||:       |...:..||   .||.|...|||......|.
Human   886 QKKD--PSGLDKKKKTSKSKAI-TPKRLLTSITTKSNIHSSVM---ASPGGLSAVRTSNFALVGS 944

  Fly  1068 AIFSLREIQRTTWTLTQV---------LG---------VSPLEGVVHMKVNCELSVSVEYKGFLT 1114
            ...||..:..|.:.|.::         ||         :|.|||.:::|:.|:::.|||.:||||
Human   945 YTLSLSSVGNTKFVLDKINYDVRERELLGYLFQEKVPFLSSLEGHIYLKIKCQVNSSVEERGFLT 1009

  Fly  1115 MFEDISGFGAWHRRWCYLNGSVINYWKYPDDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTM 1179
            :|||:|||||||||||.|:|:.|:||.||||||||.|:|.|:|.:|||:::..|.|:.|||.||.
Human  1010 IFEDVSGFGAWHRRWCVLSGNCISYWTYPDDEKRKNPIGRINLANCTSRQIEPANREFCARRNTF 1074

  Fly  1180 LLECERPALETDQESLIIVPNGRTTTVRHLLSADTKEEREEWCAYLNKALTLLRAW 1235
            .|...||..|.|:|:|:..........::.|||||||||:.|...||:.|..:|.|
Human  1075 ELITVRPQREDDRETLVSQCRDTLCVTKNWLSADTKEERDLWMQKLNQVLVDIRLW 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637	23/79 (29%)
		Anillin	929..1076	CDD:285397	43/157 (27%)
		PH_anillin	1106..1233	CDD:269964	68/126 (54%)
		PH	1107..1229	CDD:278594	66/121 (55%)
ANLN	XP_006715809.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147626
Domainoid	1	1.000	141	1.000	Domainoid score	I4707
eggNOG	1	0.900	-	-		E1_KOG3640
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2627
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003560
OrthoInspector	1	1.000	-	-		oto88314
orthoMCL	1	0.900	-	-		OOG6_106902
Panther	1	1.100	-	-	LDO	PTHR21538
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4027
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750