DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scra and mid1

DIOPT Version :9

Sequence 1:	NP_724582.1	Gene:	scra / 35696	FlyBaseID:	FBgn0261385	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_588075.1	Gene:	mid1 / 2539205	PomBaseID:	SPCC4B3.15	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	934	Identity:	185/934 - (19%)
Similarity:	323/934 - (34%)	Gaps:	285/934 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   433 AATTVVAATKPKQENKLRD-KVAALVANAQSSAETRIKDIDRQRQEDMQIISN--RFNKQKEL-- 492
            ::|:|......::|.::.. ..:|...|:.||:...:|..|        |:::  .||..:.|
pombe   109 SSTSVFKRINSEEEGRIPSLTYSAGTMNSTSSSTASLKGAD--------IVADYETFNPDQNLAE 165

  Fly   493 --FDNQPSDSSVA------AQARPPAPAPSRVVRP------MPPPPPPPIAALSPGLASSKRRSP 543
              ||...|....|      ::|:..:|....|..|      :...|....|...|.||    |.|
pombe   166 LSFDRSKSSRKRAVEVAEFSRAKTMSPLEYTVQHPYQSHNELSTNPARARAGSVPNLA----RIP 226

  Fly   544 GDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCC--AAETASATDDSHQQDE----------E 596
            .|..........|..:...|:.|:|.. |::.||..  ..||.::.|..::..|          |
pombe   227 SDVKPVPPAHLSASSTVGPRILPSLPK-DTTEDNPALERVETTASLDMDYKPLEPLAPIQEAPVE 290

  Fly   597 ET--------ESCMDESDDQSQTEDSSAGMCNGSLGREIMSAVQRNEV----------------- 636
            :|        |:.:|:||..::           ||.:::::.::...:
pombe   291 DTSEPFSSVPEATLDDSDISTE-----------SLRKKVLAKMEAKRISSGSSYASTLRKVYDFS 344

  Fly   637 EMQQQQTGKKTVRYADQDMYYDDSSLNSS-QVSAGIDDYL-DEALVEDYGSTQDDQSDSG----- 694
            |:.....||      |.|..|..||.||. ::|..|:|.| .|.:.||..:|...:|.:.
pombe   345 ELSLPTNGK------DYDELYLQSSRNSEPEISTIINDSLQQENMDEDISATSIPKSQAAYGHGS 403

  Fly   695 ---DEQNASRLSLGSKGTTASN------SFSFRKNPASICTPIEEHHEMEMDLQTPLLS---GAQ 747
               .|.....|:..|.|.:.|:      |.|...|.::|.:        ..||:.|.:.   |.:
pombe   404 VTYHEVPRYNLTSASVGYSISSQRGRIKSSSTIDNLSAILS--------SEDLRHPSMQPVPGTK 460

  Fly   748 PVKSELSVNQDNDNLVTLVH---------------TVSFYRRQQSANSS-----NSTPVRKICRE 792
            ...|....|:.|.:..:||.               ||.||......::|     .||||   .|:
pombe   461 RTYSNYCENEPNKSSQSLVSSESHNVEGWNYSETGTVGFYDPSAEISASIDELRQSTPV---ARD 522

  Fly   793 QQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIADQTDEDDEEMQNAREVNDASQAQDKIKKL 857
            .:::..|.:.|.   :||:..|..:|    .:.::.:.|     |.|:.|.|.......:   ..
pombe   523 SELLSRAHSFDL---NRLDLPSQDKS----TSYEVPNGT-----ENQSPRPVTSLGFVNE---TF 572

  Fly   858 LSEVCKQQQVIGQ----ASQALNLCAATVE------FSGSTESVEGERYLLLATHRRQACLDEVQ 912
            ..|..|....:|:    .:..||:..:.|.      .:..|::::.....:...:|    ||...
pombe   573 FEEKPKAPLPLGRFYIHLNSILNISISEVHSPIKIIVNTPTQNMQLPWQAVNGNNR----LDHDF 633

  Fly   913 RLRVENSIRPVGAPKEKGLLTVKDITIPLRQEYVRKMASNNINGHHLVCLLKYNEHVLATKTV-- 975
            ...|:::.:          ::...:.||:..:      ||...|            |.|||.|
pombe   634 AFHVDDNFK----------VSFMFLDIPIEDK------SNGSKG------------VSATKDVSN 670

  Fly   976 --PTMPGLLSVKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELKYHINLNKKGGIKTPKKKG 1038
              |......:.||.|               :::....:|           .|||...::..|.|
pombe   671 GKPAETKSKARKFFD---------------KLFNRRKKR-----------KLNKAAAVENSKAK- 708

  Fly  1039 GENRLVMPPVQSPAGPHV-------------VRTPQLVQYGF--AI-FSLREI-QRTTWTLTQVL 1086
              ..:|:..|...|..::             |..| ::..||  || ..:..| :||...||...
pombe   709 --KSVVIKKVSGTATLNLGNVKDSCFGKAFNVEIP-IISRGFLEAIPVKINSIGKRTLGNLTLTC 770

  Fly  1087 GVSPLEGVVHMKVNCELS--------VSVEY---KGFLTMFEDISGFGAWHRRWCYLNGSVINYW 1140
            ...|...|...::...|.        |...|   :|:|...||.|    ..||:..|....:|::
pombe   771 LYIPELSVPEQELPFTLEQATMDLRHVRSNYLYNEGYLYRLEDSS----IRRRFVVLRSKQLNFY 831

  Fly  1141 KYPDDEKRKTPMGSIDLNSCTSQKVTTAPRDICARLNTMLLECERPALETDQESLIIVPNGRTTT 1205
            .    ||....:.:..|    |:.|.:.|         |:...|..:      :|.:|.....|:
pombe   832 A----EKGGQYLDTFQL----SKTVVSIP---------MVNFSEAVS------NLGLVAGILATS 873

  Fly  1206 V--RHL-LSADTKEEREEWCAYLN 1226
            |  ||: |.||:|:..::|...:|
pombe   874 VDRRHVQLFADSKKVCQKWLQVMN 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637
		Anillin	929..1076	CDD:285397	30/167 (18%)
		PH_anillin	1106..1233	CDD:269964	30/127 (24%)
		PH	1107..1229	CDD:278594	30/126 (24%)
mid1	NP_588075.1	PH	805..898	CDD:278594	29/120 (24%)
mid1	NP_588075.1	PH	805..898	CDD:214574	29/120 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21538
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100