DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scra and ani-2

DIOPT Version :9

Sequence 1:	NP_724582.1	Gene:	scra / 35696	FlyBaseID:	FBgn0261385	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_495282.1	Gene:	ani-2 / 174055	WormBaseID:	WBGene00019608	Length:	1009	Species:	Caenorhabditis elegans

Alignment Length:	1329	Identity:	261/1329 - (19%)
Similarity:	435/1329 - (32%)	Gaps:	436/1329 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PFTQHMLEKAEQRSRALGISNASKF---PLVEC-SVPSSSATSASGGDAGVL-APRSR------- 55
            |.:..:......|..:|..:|.|||   |:.|. ..|..|..|.|.||...| |||.|
Worm    20 PMSSPLDSNRSYRWTSLTAANNSKFADTPVKETPQKPDMSWWSPSRGDTWRLNAPRGRTLDLVAA 84

  Fly    56 -----------SPGGQSAASGGGKVVTLGKATLEASPAKPLRHYTAVNKENLDMGIEINITTDKP 109
                       ||          :...||:....:.|.          ::|....:..|...|..
Worm    85 FDQCSRQDQLDSP----------RYANLGRYRRNSEPM----------QDNEKEVVTTNFIDDSM 129

  Fly   110 IGVQVEIQEQEVTDDEEQAEGGALNPLLEAEPVNQPLARLRDTSRSRLQRMGALYSNTDDLSSP- 173
            |....|.:|.::                                     .:|.      |...|
Worm   130 IEDHEEYEEHDI-------------------------------------ELGT------DFYDPH 151

  Fly   174 ---IHRTEGQFH--VTTGEEEDCGNRSSRQPKQRLGKLAALADTINQWEDDTSHH-EVHR----- 227
               .||:..:|.  :.||::.:..:.|:|...|.  |....:|..|....|...: .:.:
Worm   152 MIRHHRSSERFEQSLGTGQQIETIHISTRLVPQL--KRVPNSDYANDGRGDMKEYGSISKKNETP 214

  Fly   228 LLEAPPPKPH-LSSRRAEKGPAPLPPKKDEVDEASRTKQ-----LKWDPKVLSSLEAQGFQRRES 286
            :|:..|.:|. |::|...|...      :.:|...:|:.     :...|:|
Worm   215 ILDGTPKRPSPLTTRNIHKVDI------NRMDHLMKTENTVAGFITLTPQV-------------- 259

  Fly   287 STIKHTYDYAK---QEEAAPASKVEDAVLTAKPPVPQKSTTVSQ--VAKNFASSAPAPKPAPAPA 346
            |.:.|..|::|   |||:..||           |:.:::...:|  |..:|.|.|...|..|:|.
Worm   260 SKVTHKSDFSKHFGQEESVRAS-----------PMSRRNRRGTQTIVLPSFDSPASVRKSIPSPG 313

  Fly   347 VSVK------SGLVSGRAALFENKGTGGQSQGLRNQKDPCELSLKERMKLFETGNNKAMLPMAPI 405
            :..|      |.||...|..||....|...:                                 |
Worm   314 LPTKTDIRSPSSLVKSIANDFEKADFGFHRK---------------------------------I 345

  Fly   406 GSAPSITQIRAEEVKQHLAAMHPVTAAAATTVVAATKPKQENKLRDKVAALVANAQSSAETRIKD 470
            .:|..|.|:|                           .:.:|...|:...:|::   |||..
Worm   346 DAAEEIAQLR---------------------------KRADNSTFDENQNMVSD---SAEDN--- 377

  Fly   471 IDRQRQEDMQIISNRFNKQKELFDNQPS-DSSVAAQAR----PPAPAPSRVVRPMPPPPPPPIAA 530
                       :||.|..:....:..|| ...::..|:    |...:...|:..:|
Worm   378 -----------VSNDFVPRISHLEMHPSVHMGISGYAKKNHVPYGESNEEVLYSLP--------- 422

  Fly   531 LSPGLASSKRRSPGDAPTTDEDSKRARKSHSDRLYPALSDLDSSGDNCCAAETASATDDSHQQDE 595
                   .|::|                          .::|..|
Worm   423 -------IKKQS--------------------------RNVDREG-------------------- 434

  Fly   596 EETESCMDESDDQSQTEDSSAGMCNGSLGREIMSAVQRNEVEMQQQQTGKKTVRYADQDMYYDDS 660
                  ||::|:...|.            |.|.........::.:::|..|.           |.
Worm   435 ------MDQTDEILLTP------------RAITMRQSLPFSDIPEERTCDKI-----------DE 470

  Fly   661 SLNSSQVSAGIDDYLD----EALVEDYGSTQDDQSDSGDEQNASRLSLGSKGTTASNSFSFRKNP 721
            ..:..:|..|  ||.|    |..|:.|...:..:|.:...:|  ||.|   .|.......|.|:
Worm   471 MFDFVEVPTG--DYDDKTTLERTVDGYAEVKSQKSPNKMIRN--RLDL---STNTYQEIEFEKD- 527

  Fly   722 ASICTPIEEHHEMEMDLQTPLLSGAQPVKSELSVNQDNDNLVTLV-----HTVSFYRRQQSANSS 781
               .||..:..|.:....:...||.|..:|.           |||     .:|:.||   .::..
Worm   528 ---TTPYMQEFEEDGTGYSASSSGPQFTRSP-----------TLVTPHAGQSVAEYR---VSDKE 575

  Fly   782 NSTPVRKICREQQVMRSALAGDCHAKHRLEYDSPQQSDYVAAATDIADQTDEDDEEMQNAREVND 846
            ......|:..::....||||... .|....:.:..||:    |.|  |...........|.::||
Worm   576 GCAKTEKVVVQKMSQPSALATST-PKGTFAWRNKNQSN----AAD--DSFVSSISNFSAADKIND 633

  Fly   847 ASQAQDKIKKLLSEVCKQQQVIGQASQALNLCAATVEFSGSTESVEGERYLLLATHRRQACLDEV 911
            :.:   :|.||:..:.|.::.|..|..:| :.|...:.  ..:.:..:|.||:...|.:..||||
Worm   634 SKR---QISKLIETIEKTRKHIQLAEISL-IDAKRAQM--VVQELASQRVLLICRERLKLQLDEV 692

  Fly   912 QRLRVENSIRPVGAPKE---KGLLTVKDITIPLRQEYVRKMASNNINGHH-LVCLLKYNEHVLAT 972
            :||:..:.:|....|..   |..:.:.:|.|.|.:.:       |..|.. .:..||....:.||
Worm   693 RRLQALSVVRHPPPPINRHFKSAMVISNIAIHLNKNF-------NCRGSFAFIVALKCRTEIEAT 750

  Fly   973 KTVPTMPGLLS----VKFPDVLQLNNVYADFRITLEIYGMLAQRDQLPHELKYHINLNKKGGIKT 1033
            ..|..:....:    :.|.:.:..:|:..||.|.:|:|.|.....:.|.:....:...|...:..
Worm   751 GVVTLLAHYQTRMHVIHFGEHMHFSNLPVDFVIAMEVYMMRVPEYKAPEKTCAAVLAAKFRNLLV 815

  Fly  1034 PKKKGGENR----------LVMPPVQSPAGPHVVRTPQLVQYGFAIFSLREIQRTT-----WTLT 1083
            |.......|          |.||..|:|            ...|.......:.|.:     :.|.
Worm   816 PNSAHRRARNNSVLSNRTVLSMPGYQAP------------DCDFRFCGKLTLDRDSAGDRQFYLD 868

  Fly  1084 QVLGVSPLEGVVHMKVNCEL---SVSVEYKGFLTMFEDIS--GFGAWHRRWCYLNGSVINYWKYP 1143
            .|  ..||||.|.::.:|..   ::.|||:|||.:|::.|  |..||.|.|..|:..:|.:||.|
Worm   869 DV--TYPLEGTVKLQSHCSSLPEAIDVEYRGFLYLFDERSPNGEAAWDRYWAMLHRGIIFFWKNP 931

  Fly  1144 DDEK-RKTPMGSIDLNSCTSQKV--TTAPRDICARLNTMLLECERPALETDQESLIIVPNGRTTT 1205
            .||| :|.|:..|||..||:|.|  |...||  ...:..||..:.|:|...:
Worm   932 IDEKNQKVPLSQIDLTKCTNQSVEETRNGRD--HEFHIELLIDQTPSLLEKR------------- 981

  Fly  1206 VRHLLSADTKEEREEWCAYLNKALTLLRA 1234
             |.:|:|::.:....|...:|..|.:||:
Worm   982 -RVVLAAESSDHLASWLNAINDTLFVLRS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scra	NP_724582.1	Anillin_N	153..227	CDD:292637	15/80 (19%)
		Anillin	929..1076	CDD:285397	29/161 (18%)
		PH_anillin	1106..1233	CDD:269964	43/131 (33%)
		PH	1107..1229	CDD:278594	42/126 (33%)
ani-2	NP_495282.1	Anillin	712..861	CDD:285397	30/167 (18%)
		PH_anillin	892..1008	CDD:269964	43/131 (33%)
		PH	893..1004	CDD:278594	42/126 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3640
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I3347
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21538
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2397
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880