DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vps13 and AT3G50380

DIOPT Version :9

Sequence 1:NP_001260781.1 Gene:Vps13 / 35693 FlyBaseID:FBgn0033194 Length:3321 Species:Drosophila melanogaster
Sequence 2:NP_001326732.1 Gene:AT3G50380 / 824202 AraportID:AT3G50380 Length:3132 Species:Arabidopsis thaliana


Alignment Length:3640 Identity:645/3640 - (17%)
Similarity:1183/3640 - (32%) Gaps:1141/3640 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QLKIGIWGGDVVLQNLKIRENALDEL--DLPVQLIYGYLGKLVLKIPWKNLYSQPVI-VNIEDLY 87
            |:::|.....:.|::.:...:.|::|  :...|.....:.:||:..   :::|.|.| ..|..:.
plant    27 QVELGFTDTLITLRSFRFDVSQLNQLFDESNFQFEKFTVDQLVVSF---SVWSAPAIKFEIRGVN 88

  Fly    88 VLVSPNNNVQYNAEKEAKYEMDLKKAALDALEAARKKELEMDQPKADA--GFAEKL----TAQIV 146
            |.:|.....:.::.:        |:|:.|.:....||.|....||...  ...||:    |:|| 
plant    89 VKLSARGTDEGSSRR--------KRASSDTVANEIKKVLSSIDPKGCVLHDILEKMLGRSTSQI- 144

  Fly   147 NNLQVQITNVHLRYEDTTTTGSPFSFGISLHELELYTTDCDWEKCYMAQQASQVFKIANLSCLSA 211
            :.|:...:|:.||:           |.|.:|.:.:                 ||       ||. 
plant   145 SKLKTSFSNLILRH-----------FRIQIHGINV-----------------QV-------CLP- 173

  Fly   212 YLNCGGQLYANNKSDLSQQFKTNIACKETKPNYNYVLGPISCNAKLKLNMNPELDDPPFEKPKID 276
                       ..||||...:.|....:::...|..|...|..|.|            |...:..
plant   174 -----------GSSDLSCLMEINELRSDSENFGNLSLVRSSAAAVL------------FPLRRSS 215

  Fly   277 LTLEMEKLNVGLTNTQ-------FDNLMKLGDAMNRQQLGIPYR------KYRPYNIP-YKGHAR 327
            .||.....|:|.....       ||:|:.|....|.|.:.:..|      .:||.::| ..|.|.
plant   216 FTLSCFGFNIGYKRDNEIVDLCGFDSLVMLITLHNLQLVDLVVRVPELSFSFRPTDLPVLMGLAN 280

  Fly   328 DWWHFAITSILEEEVRKPRESWTWGHIKTHRERCNTYAQKYKEQCLSKKPSAVLTETCRLLETEL 392
                  ::|.....||..|..|     |....|..          |...|.:|..:..       
plant   281 ------LSSKDSNYVRNGRYLW-----KVAARRTG----------LMISPHSVSFQNL------- 317

  Fly   393 DVFNLLLIRQRVN-----IEIAKQREAVPEQKSGW-FSGWGWGGGAKKDDQTTSQK--LVEKFEA 449
             |..::|..:.||     :.:|.....:||:...| ||      ..|:...|..:|  ::...|.
plant   318 -VSVVILWLRYVNAYEYLLSLAGYSRKMPEKSLLWKFS------ENKRHFVTARRKWEMICNIEK 375

  Fly   450 AMTSEEKEKMYRAIGYQENAKPTDLPESYEAIRMNFKLIALEVGLYKDERNSSAAT--------- 505
            .:.:|...:..|...|:......|..:.|:           |..||...:..|..|         
plant   376 ELPAEAIARARRVARYRACLNSQDADDDYD-----------ESSLYGHFKYLSKTTWVLAYIWRL 429

  Fly   506 --KDFHELPSLVLLNFSMATALITQR---PAAEAISI----IAGMREIKVT---------GLTRN 552
              :.|..:...:.||..:...|.|.|   ..:|.:|:    :..:.::.||         .:|..
plant   430 ISRTFWSIACFLWLNKLLTQELQTDRNNEDDSECVSLEFHAVVNLGKLSVTCYPEKIISSFMTSK 494

  Fly   553 DYTPLLVESKI------TDEFNLL-EVFFETNPLDKLCDQRVKVVARPLQITYDAPTILALINAF 610
            |.|. .|:|.|      .|||.:| .|...|..|...|. ::||.:...:.|             
plant   495 DSTG-HVDSNIVMLCLSVDEFLVLYTVGCLTQYLSASCG-KLKVESSSFKNT------------- 544

  Fly   611 QTPGDVTLSKF----EDAASTKISNFKERSATGMQYMIDKKAVLDVDILLMPNILVVPHKGVYDA 671
                    |:|    :|.:|:...|.|....       |.|.:||:|                .|
plant   545 --------SRFMKSTKDPSSSSEGNKKHMRE-------DVKTILDMD----------------PA 578

  Fly   672 GNVSLLVVS------MGQVHLSSQPRR-----ESN--KLQHLFSAGEDKDEIL---KTVMENAYD 720
            ..:|..|.:      .|.:||.:..|.     .||  ||........||..:|   |:.|  ||:
plant   579 QQISKTVNNHGSDQHEGMLHLQNLLREMWLNWNSNCMKLDKSTFTISDKPCLLVDIKSCM--AYE 641

  Fly   721 RFTVAVDDVQM-----------------------LVVRAGEPWQNALAEANSTEMHVLRPVSLKV 762
              .|...|.:.                       |::...|..|..|.:..:.|:|         
plant   642 --VVGNQDSEFWKCSMVLGKLDIVFEYSSLFSLALLIWQIEWAQKLLVDDYTGEVH--------- 695

  Fly   763 TAALCVVDNDPRLPN------IKVDIDLPAILVNVSEDRIFLAIKVATSIPLPEQKEPASRLTQT 821
            :::|.....||.:.:      .:..|:|.  |..|..:|   .|:|...:..|:.|....:..:.
plant   696 SSSLVTGGVDPEMASYDEYGIYRRSIELS--LHRVHPER---QIQVGILLGGPQIKLLVEKAEEV 755

  Fly   822 NSRSSMSISNFINKEVKKIGPSASGSSASKDPLLDEIIQYTSLDVNFSLGEINFVLFQSSRKCET 886
            |:        .|.|               ||.||            |...:..||::.       
plant   756 NT--------LIGK---------------KDILL------------FDFHDFEFVIWP------- 778

  Fly   887 SPDVSIEFLTPDGDVLPSQLTENIQEPIEELPPTPPQQILSIDIRRLEAH--FVSKTYESVATVK 949
                     |...||:.|::   .|.|.......|..|.|.:....:.::  :||:.:.|:::  
plant   779 ---------TYKSDVVSSRM---FQGPDNIRTDRPLLQELGLSDTVIPSYEKYVSQGWNSLSS-- 829

  Fly   950 LGDINLRQYDCQDSDMDVLDVIYTPKQENSSNYLFTVSCTIADKSSPEFSTKYNSTEQLVVANFE 1014
              .:....:||....|.|         :|.|........||...|..|  ..|:.:|.::..:..
plant   830 --HLRFSGFDCSFCKMAV---------KNWSQVFVVRPVTICFSSLRE--NVYSFSEAIMDFSIG 881

  Fly  1015 VLQIVLHQECLQRIMEVVNNFQRNLDLVLSSTRPRDRMGSIGGGDGIKRTLNVILEDTEEIMTTD 1079
            :...||....:.:..::...||..|.||...:|....:.|.|...|            :|.:.:|
plant   882 LDVFVLGLTIVTKPDDLNAYFQMLLSLVSGLSRGLSGLSSGGHSSG------------QEFLRSD 934

  Fly  1080 QMKRRKKTRRTHVVETVKVRVIANLDQVGLV-----LTGRKRPIAEMNVKKFVSSLIIKSSYTEV 1139
            .:....:..|........|:....|..:.::     :..:...:.|::..|..||  ::.:..|:
plant   935 AVNVEHEIERNPCKTLFVVKASIKLKDIDVIFDVPAVDDKFERLVELDDTKIWSS--VQEACIEL 997

  Fly  1140 NIGLKDIQVLDLNPYTIHKNILSIVGKDAFNCQIVIYNKEETQDYNSDDMKITVDIGCMKIIFLN 1204
            ::             ..||.::::   |....|.|:: |.|...:.|....||     ..::|.:
plant   998 SV-------------EEHKCLINV---DLCKLQSVLF-KFEGNIWKSSGNFIT-----ESLLFRS 1040

  Fly  1205 WFVAGVMNFLNNFTAAQATISQAGAAAAESARQKAMDAYETATRMKLNIRIKAPI-------IIV 1262
                  .:.|.....:...:|.:...::.||...|..|.|.:|.   |::::..:       .::
plant  1041 ------HDILFEACLSSCLLSVSMDCSSPSALGDASTANEPSTN---NVQVQREVKTLDSASDLL 1096

  Fly  1263 PIGS---QDRNALLLDLGLLELTNNTVEVAVAEEERLAVIDEIKLQI----CDVKISKIVLLDGN 1320
            |..|   ...|..|.||.:.:.:...|.|.|....:......|..:.    |.|:....||    
plant  1097 PSNSIRWMHINLALTDLLVAKGSTKNVLVDVRRSSKFVTSVSIGRRFQSISCSVEGVLFVL---- 1157

  Fly  1321 ESTVDEVDAEVGFLSKFN-MMNPMSCTLSITRNLS-----YTWYRDVPELNLSGRLK-------- 1371
                 |..|.:|.:..:: .:..:|..:|:.:|.:     :.....|.|:::..:.:        
plant  1158 -----EPKALIGLIHGYSTYLYLISSKVSVIQNSAPVLEKFEADSSVTEISIPSQQENGYPVEAF 1217

  Fly  1372 SIELTLFA------DDY-ALVMLVLNRNLNEGLEEFPPSEEAPQEAQVRPERRNSRAGRLSRTVQ 1429
            ||::..||      |:| |:..:||...|:..|:                    |..|......:
plant  1218 SIDVAQFALGFVCDDEYGAIREIVLEITLHSSLD--------------------SAGGEQKFLCE 1262

  Fly  1430 VS--PIREKIHESIKFNFQFDGVVINLMEGEGAGLARFGIYFLSVKGTKLDNGTLSTSVVLCNIQ 1492
            ||  .:..||.||::.:       ||:.:......:.....||  .||.|:.          :.|
plant  1263 VSRLSVLSKILESVERD-------INITQFSSPAFSSESSSFL--PGTPLET----------SFQ 1308

  Fly  1493 MDDMRSNSKS--------QIRQYLSRKDWVQPKLDTDEIIDACYNERNFMVD---VTAIIKEDDT 1546
            ..|:.|:..|        .:|::.:..       :..|...:.||  |::::   |:|.:|:.:.
plant  1309 QSDVISSGDSTSVSGDFNSLREFSANS-------NLQEEFHSRYN--NYILEDLRVSASVKKREN 1364

  Fly  1547 ----FAEV-----RVRGFDLIVCID----FLLKLTTFLTLPPEENPRESVYIKPAPVSETARDTK 1598
                |::.     .|.|||:.:.:.    .|..|:.|..:|..::...|:....:..||:.|..:
plant  1365 TGHQFSQAWAGACSVLGFDITISLSELQMVLSMLSLFAAIPGGDSAHASLERPSSFNSESERSFE 1429

  Fly  1599 HSIRSSAILAAQELVPVESSSHEVPNRKMNLILHIDEPDIILVENLEDLNTSCIIFNAQVHLNYR 1663
            ..:...||:|.|::           |:.|.:             .:||....|::...   |:|.
plant  1430 SVVPDGAIVAIQDI-----------NQHMFV-------------TVEDGGNKCVVTGT---LHYS 1467

  Fly  1664 SINDKQIVNGQIDALKMYMCAFLPERREMTRHY-----ILHPCVISLQGSTPEEEGMHISLKLSD 1723
            .:.::.:.                 |....||.     .|...:.||.....:.|.:.::...|.
plant  1468 LVGERALF-----------------RVSYHRHQGWNSSTLWFSLTSLYAKNNKGEPLRLNYHSSS 1515

  Fly  1724 IIINVSPATIELLNKA--MLSVSSGTMTKCAIAEESRNYSN--LWHQHH---------------- 1768
            .|:|||    .|.:.|  :...|||         ||.||..  .|..:.                
plant  1516 DIVNVS----GLYDNAPTLFRASSG---------ESENYKGDIDWETYRKLVKDTFYLVNKKSDS 1567

  Fly  1769 -----------------------FHS--RTYWFTKVEQGVDALEAEQRSVSTDNEKQKTEKCVIE 1808
                                   ||.  .|...|.|... :..|:|..||..|:..         
plant  1568 AVAFIDGFPEFVRKPGNPFKFKVFHESLATRSLTPVVPS-EIHESETHSVMVDSSP--------- 1622

  Fly  1809 IPSITLVIESGVGY-------YTK---PLISLDTRIT----AVFNNWSRSLTAHGSLTLNMNYYN 1859
             ||||:.|: ||..       .|:   ||......||    .:.::..|.::....|.|   |::
plant  1623 -PSITVTID-GVSLTIVHELSETRDRFPLFRGSVNITQLTVQMLSSKVRIMSTSNILVL---YFD 1682

  Fly  1860 QALAEWEPIIELNEVIGRNGVREYTPWELKFEMGMEKVQSELEDDAEQQAMHMNIHSAET----- 1919
            ....:|...|.              |.|         |.:......:.:.::..:|...|     
plant  1683 AQTNQWREFIH--------------PVE---------VSAFYRSTFQTRDLNNTMHKVPTHIYCR 1724

  Fly  1920 ---LEITLSKTCLGLLSELAEAFSQAIDQNGLTKPDIVAPY------------VLENDTGFD--- 1966
               ||:.|::..|.:|..|            |.|.:...|:            .:||.:|.|   
plant  1725 IGKLEVFLTELSLDMLLFL------------LGKLEFAGPFSVKTSAILSNCCKIENLSGLDLIC 1777

  Fly  1967 ---------VNLNLRKGIFTLHEVH--RGGTPVGANSTLLMVAQSEEVDPSVIKTCTISTGGRAY 2020
                     |.......||..|.::  :..:||.|.........:..::.|:::..|::      
plant  1778 RFNEKQTATVGRKQTAAIFLRHSMNHQQEASPVAAVQLSSGKFITSSINVSLLEARTLA------ 1836

  Fly  2021 LQTKDLSTLSEEDSEDYTLYVTIGDINK--EIALPVSKSD-TRFFN---------LMRSTSHEPW 2073
            .:|:.:|.|   ||..:.....:.||.|  |..|.:|.|. ||..|         ..||      
plant  1837 WRTRIISLL---DSRSHPGPFVVVDIKKGLEDGLSISVSPLTRIHNETSLPIEIRFQRS------ 1892

  Fly  2074 GIISEVKQEYGTTKV----NIHGVVSVHNHFT---------TGLNIYRRNPAPTAQCFEDIFVGR 2125
               .:.:.|:.:..:    :|...|:..|..:         |.|.:...:.:...:.||.:|.|.
plant  1893 ---KQKRDEFASVPLKPGGSIDDSVAAFNAISSSGDMKKALTSLAVGNFSLSFRPESFETLFEGE 1954

  Fly  2126 VRPGEVFHVPLHAIYAESKDLFFSMRGY----RRSVQGISWASNPSDLNYSHQLHCDPTNTFEPL 2186
            ...|..:...|....|......|....|    ..|::.:..:...:..:.:.:..|.....|  |
plant  1955 KSLGSEWSEELEGGKAVRLTGIFDKLSYGVKKALSIESVKVSLTTTYCSVTSESQCVGKVHF--L 2017

  Fly  2187 IMNARRSKSEV-------YFENTNKYTLLSAFYTIHLRPPLYLRNSLPINIQV---------SVA 2235
            |.:.||..|.:       ..|.......|.....|.|.|.:.:.|.|.....:         |:.
plant  2018 IHSIRREVSIIRPDASSDVLEKQKACIALREQKEIFLLPTVQVSNFLSSEAAILLTETDQNTSME 2082

  Fly  2236 GCSVRKEDGLDAQSSQRFVDRGYRKEDFLDY---------GEKPVNSGDVLHLPTVRLASKGKES 2291
            ..|:.|...:.:..:..|    |...|.:.:         ..||||||.                
plant  2083 RHSIGKHATIQSGKTIDF----YVNPDMIYFRVTLTTSQASCKPVNSGQ---------------- 2127

  Fly  2292 KSFLVVRLVQYLEKDWSCATEIWDYTDDVITWTFSSYDSEMKVDMDLYVKTENRHGSLMLTLFSP 2356
                .|:.:|..:.|..|.....|::.       ..|.:.:::.:       .:.|.|...:|:.
plant  2128 ----WVKKLQKQKNDAQCLDVDLDFSG-------GKYCASLRLSL-------GKRGILEAAVFTS 2174

  Fly  2357 FWMINKTGMMLTY------KSETTSVEVLYH--PPEYSGPILFTFRDKLFFDKKKASIRIDNGQW 2413
            :.:.|.:...|.:      ......:|.|.|  |||:...:........|...:|..:.:.:|..
plant  2175 YILKNDSDCTLFFFPPDQKPLSREDMEKLDHIVPPEFGLYLPPKTEGSWFLRSRKVGVILADGHG 2239

  Fly  2414 SEK--IPLDVAGSVGEVICFANNQ-------KYPVGVHNHLTQNSL--TKQITFIPFYIVCNKC- 2466
            :.:  :.||....:.|:.....::       ::.:.|.: ::...|  ::.:||:|.::|.|:. 
plant  2240 ATEAVLDLDALSGLTEISLGTKDESGFRYVTRFGLSVRS-ISSKMLVPSRIVTFVPRHLVINESE 2303

  Fly  2467 -------HF-----------------DIELQEQSRPADPWLHLEPNEMEPLWPRNDTKNNLVVRV 2507
                   |:                 .:.|||::..... |||..|.::.  ..:|:.|:|:. :
plant  2304 ETINIRQHYFQDDSVGIITIKSKQRAALRLQEETIQKKE-LHLFENFIKK--HGSDSANSLIF-I 2364

  Fly  2508 DGKITPA-------FDFTEVICTLLKLE----DSKYGGIN-VDVQTTEGGVYITFTDYKPADAP- 2559
            ..::..|       ...|.:.|..:|..    ::..|.|. ..|..||.|..:.....||.:.| 
plant  2365 QFRLNKANWSWSGPLCITSIGCFFIKFRKQSGEAGRGAIEFASVNVTEEGSTLAVHFQKPPNTPP 2429

  Fly  2560 -----GLLINHTGKQIVYHEKGTKNEHILNAKSTIMYAWDDPTGPKMLVFGTN----KEETDL-- 2613
                 ..|  |:. .:.|::|.:....:|...|...|||||.|.|..||...:    ..|..|  
plant  2430 PYRIENFL--HSA-SLTYYQKDSSEIEVLGPGSGADYAWDDMTLPHKLVVIVDGMIPLREVSLDK 2491

  Fly  2614 ------------KRDGIGEVIMQDGG----------------KVLWVSFLDGLQRVLLFTENESI 2650
                        .|.....::|:...                ||.:..:.|||.||:...|   :
plant  2492 VRPWKPLFKATQHRSIASHLMMKKKAKDHKTADKELSRIPMVKVGYEVYADGLTRVIRICE---V 2553

  Fly  2651 ANRTESTASLQSITQSIDLRIHGIGLSVINNETGLDILYLGVTSSGIIWESKKVTKNRFKELTIN 2715
            :...:..::.|| ...|..|:..:|:.::                      :||.:|..::..::
plant  2554 SESLKGDSAFQS-RSKIQFRVTHLGVHLL----------------------EKVKQNAEEKTVVS 2595

  Fly  2716 ENALLEIEYQKYLVHKSVNDVQTYKLDNKFPIDFDLMILKKTVERNLRRSFYPAIWLSRKSSPFQ 2780
            .:.:|....:...:|....|.|.:.                                        
plant  2596 YSPILVARLENVGLHSMFTDQQKFN---------------------------------------- 2620

  Fly  2781 SQLHVKINRIQVDNQFLDPIFPVVLAPIPPPKSVASTTSLKPFIECSMVQRIMPNSTVRQFKYAR 2845
               .:.|..:.||:::....|..:|.......|.|:....|    |..: .:...|:|.|.|::.
plant  2621 ---QLCIEALNVDHKWAGAPFAAMLRQHQSSSSDANGCLFK----CVFI-LVSSGSSVTQVKHSS 2677

  Fly  2846 ILIQEFLFKVDLNFLTAIAEMFAKEVSDEAAAKQFRQDVESIELPLSAFFEEHSLEEQKSFYDNL 2910
            |::|.....:|...|..:...:...:|....:.|:                         ::|:.
plant  2678 IVLQPVNLNLDEETLMRVVAFWRSSLSTNTQSSQY-------------------------YFDHF 2717

  Fly  2911 HLGPLKIHV------SFSMAGSDTKALPGFLGSLVQGVGVTLTDVNDVVFRLAFFEREYQFFSQK 2969
            .:.|:||..      |:|...|..:.|...|.|:|:     :..:.::|..|......:...:.:
plant  2718 EIHPIKITANFVPGSSYSSYNSAQETLRSLLHSVVK-----VPHIKNMVVELNGVLVTHALITVR 2777

  Fly  2970 QLINEITSHYTGQALKQLYVLVLGLDVLGNPY------GLVVGLKKGVEDLFYEPFQGAIQGPGE 3028
            :|:.....||:..|::.:|:      ..|:|.      .:.........|.|::|.:|.:..|  
plant  2778 ELLLRCVKHYSWYAMRAIYI------AKGSPLLPPAFASMFDDFSSSSLDAFFDPSRGLVNVP-- 2834

  Fly  3029 FAEGLVLGVKSLFGHTVG--GAAGAVSKITGAMGKGL---------AALT--FDEDYQKKRRQGI 3080
               ||.:|...|....:.  |.:| ..:..|.:||.|         .|||  .|...:....:|:
plant  2835 ---GLTVGTFKLLSKLIDNKGLSG-TRRYFGDLGKTLRTAGSNVVFVALTEISDSVLRGAEMKGV 2895

  Fly  3081 QNKPKNFHEGLARSS-------KGLVMGFVDGVTGVVTKPVTGARDNGVEGFFKGLGKGAIGLVA 3138
            ......||.|:.:.:       ..|:.|..|....:...|  |..:..:||:.:.:    :..:.
plant  2896 DGLVSGFHHGILKLAMEPSVIGTALMEGGPDRTIKLDRNP--GIDELYIEGYLQAM----LDTMY 2954

  Fly  3139 R-------------------PTAGVVDFASGSFEAVKRAADASE-------DVKRMRPPRFQHYD 3177
            |                   |:..::|      |.:.|..|..|       |....||.|..|.|
plant  2955 RQEYLRVKVIDDQVFLKNLPPSNSLID------EMIDRVKDFLESRGLLKGDPSSSRPRRRLHGD 3013

  Fly  3178  3177
            plant  3014  3013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Vps13NP_001260781.1 Chorein_N 4..113 CDD:315323 15/89 (17%)
VPS13 140..370 CDD:318996 49/247 (20%)
VPS13_mid_rpt 574..807 CDD:318998 53/281 (19%)
SHR-BD 2349..2600 CDD:310922 59/312 (19%)
VPS13 <2701..3232 CDD:330393 89/535 (17%)
VPS13_C 2904..3074 CDD:318997 39/194 (20%)
AT3G50380NP_001326732.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5043
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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