DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13 and Vps13b

DIOPT Version :9

Sequence 1:	NP_001260781.1	Gene:	Vps13 / 35693	FlyBaseID:	FBgn0033194	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	NP_796125.2	Gene:	Vps13b / 666173	MGIID:	1916380	Length:	3993	Species:	Mus musculus

Alignment Length:	4364	Identity:	778/4364 - (17%)
Similarity:	1374/4364 - (31%)	Gaps:	1606/4364 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VFEAVVADVLNKVLGDYIENLDRNQLKIGIWGGDVVLQNLKIRENALD-ELDLPVQLIYGYLGKL 65
            :.|:.|..:|...:..||:||..:.|::.:|||||||..|:::.:.|: ||.||...:.|::.:|
Mouse     1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHEL 65

  Fly    66 VLKIPWKNLYSQPVIVNIEDLYVLVSPNNNVQYNAEKEAKYEMDLKKA--ALDALEAARKKELEM 128
            .:.:||..|.|:||::.|..:..::...:.:|.:.|.......:...|  ...:::..|.::...
Mouse    66 RIHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTNRSTAENTKSSIKPRRIQQAAP 130

  Fly   129 DQPKADAGFAEKLTAQIVNNLQVQITNVHLRY-EDTTTTGSPFSFGISLHELELYTTDCDWEKCY 192
            ..|....|:.:.|..::|||:.:.|.|:.|:| ||...      ..:::...|.||....|::.:
Mouse   131 ADPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------LSVNITSAECYTVGELWDRAF 189

  Fly   193 MAQQASQVF--KIANLSCLSAYLNCGGQLYANNKSDLSQQFKTNIACKETKPNYNYVLGPISCNA 255
            |...|:.:.  |..|.|      :|...|...|.|...:.::..:..|              |:.
Mouse   190 MDISATDLVLRKAINFS------DCTVCLDKRNASGKIEFYQDPLLYK--------------CSF 234

  Fly   256 KLKL-----NMNPELDDPPFEKPKIDLTLEMEKLNVGLTNTQ---FDNLMKLGDAMNRQQLG--- 309
            :.:|     |:|.::..      .|.:...:|.|.:.:|:.|   |..:|:||.|:...::|
Mouse   235 RTRLHFTYDNLNSKMPS------VIKIHTLVESLKLSITDQQLPMFIRIMQLGIALYYGEIGNFK 293

  Fly   310 ----------------------IPYRKYRPYNIPYKGHARDWWHFAITSILEEEVRKPR--ESWT 350
                                  ...|....|..||||.          .:..::..:|:  .||.
Mouse   294 DGETEDPPCLSKDTLANLTGTEEESRIDMQYPAPYKGQ----------ELYSQDYEEPQGWVSWA 348

  Fly   351 WGHIKT--------------------HRERCNTYAQKYKEQCLS-----KKPSAVLTETCRLLET 390
            |..:..                    |:::    ||..|:..:|     .|    .|.|.:|  |
Mouse   349 WSFVPAIVSYDDGEEDDLGTDPASIMHQQK----AQTLKDPIVSVGFYCTK----ATVTFKL--T 403

  Fly   391 ELDVFNLLLIRQRVNIEIAKQREAVPEQKSGWFSGWGWGGGAKKDDQTTSQKL------------ 443
            |:...|.....|:|     |.:|.:..::.|                ||.:.|
Mouse   404 EMQAENSYYSPQKV-----KSKEVLCWEQEG----------------TTIEALMMGEPFFDCQIG 447

  Fly   444 --------------VEKFEAAMTSEEKEKMYRAIGYQENAKPTDL------------PESYEAIR 482
                          |:.||..|...|.|..:...|  ||.....|            ||: ...|
Mouse   448 FVGCRAMCLKGILGVKDFEEHMNRSETEACFFICG--ENLSTKGLTYLTNSLFDYRSPEN-NGTR 509

  Fly   483 MNFKLIALE--------VG-----------LYKDERNSSAATKDFHELPS-----LVLLNFSMAT 523
            ..|.|.|..        .|           ||..|.:|........:.||     |.::......
Mouse   510 AEFILDAAHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKGPTSQQDFPSGKNEDLGIVQEKSTK 574

  Fly   524 ALITQ----RPAAEAISIIAGMREIKVTGLTRNDYTP---LLVESK-----ITD--EFNLLEVFF 574
            :|:..    |..:.|:..:..|    :.....::|.|   |..|||     :.|  |.:.||.:.
Mouse   575 SLVIGPLDCRLDSSAVHRVLKM----IVCALEHEYEPYSRLKPESKDEKETVLDPEEVSSLEEYI 635

  Fly   575 ETNPLDKLCDQRVKVVARPLQITY---DAPTILALINAFQTPGDVTLSKFEDAASTKISNFKE-R 635
            .|               |...:|.   .....:|..|.......|.:.....:..|..:||:. |
Mouse   636 PT---------------RHTSVTLLKCTCTVFMAEFNLLDCLLPVIMGGKNSSNVTNATNFQSLR 685

  Fly   636 SATGMQYMIDKKAVLDVDILLMPNILVVPHKGVYDAGNVSLLVVSMGQVHLSSQPRRESNKLQHL 700
            ....:|.::||              :.:.|         |:.:.:...||:.|...:.|:.|.|.
Mouse   686 PLPSIQILVDK--------------INLEH---------SVPMYAEQLVHVVSSLNQPSDNLLHY 727

  Fly   701 -----------FSAGED----------------------KDEILK-----------TVMENAYD- 720
                       |.||..                      ..::||           .|.|..::
Mouse   728 CYVHCYLKVFGFQAGLTCLDHSGSYCLPAPIIPSFSTALYGKLLKLPALWTKRSQTVVTEGIFEL 792

  Fly   721 -RFTVAVDDVQMLVVRA-GEPWQNALAEANSTEMHVLRPVSLKVTAALCVVDNDPRLPNIKVDID 783
             ..|:.....|.|:::| .:.|.:....::||....|......:|.   |...:| ||.::..|.
Mouse   793 PNLTIQATRAQTLLLQAIYQSWSHIGNVSSSTVNEALMNEVFPMTG---VKSKNP-LPTLEGSIQ 853

  Fly   784 ------LPAILVNVSEDRIFLAIKVATSIPLPEQKEPASRLTQTNSRS-SMSISNFINKEVKK-- 839
                  ....||..:...:. :||:....|....||....|.|..|.: .:..|.::|:..|.
Mouse   854 NVELKYCSTSLVKCASGTLG-SIKICAKAPGDSGKEKLIPLLQGPSDTRDLHSSKWLNESRKPES 917

  Fly   840 -IGP-------------------------SASGSSASKDPLLDEIIQYTSLDVNFSLGEINFVLF 878
             :.|                         |..|.:.:.||:|     ||            :|::
Mouse   918 LLAPDLIAFTIQVPQYMDYCHHSGAVFLCSVQGLAVNIDPIL-----YT------------WVIY 965

  Fly   879 Q----SSRKCETSPDVSIEFLT---------------PDGDVLPSQLTENIQEPI------EELP 918
            |    ::|..:..|.|::..:|               |.|.....|.:|....||      |..|
Mouse   966 QPQKRANRHAQQQPVVAVPLVTSVNRRKEDELSIGSAPLGKQQSYQASEYASSPIKTKTVTESRP 1030

  Fly   919 PTPPQQ------------------------------ILSIDIRRLEAHFVSKTYESVATVKLGDI 953
            .:.|.:                              .|.:|::.......:....|.:|:..|||
Mouse  1031 VSVPVKAVLRVHEECRSPEDKMKEFIAILWNAVKSLTLQLDVQSCCVFIPNDNLPSPSTIVSGDI 1095

  Fly   954 --NLRQ-YDCQDS--------------------DMDVLD----VIYTPKQENSSNYLFTVS---- 987
              .:|. |..|.|                    .|:.|.    ||..|..|....:.:|:|
Mouse  1096 PGTVRSWYHGQTSIPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHHF 1160

  Fly   988 -------------------C--TIADKSSPEFSTKYNSTEQLVV---ANFEVLQIVLHQECLQRI 1028
                               |  |:|..|........:.....||   .:.|.|:|......:|.|
Mouse  1161 SIYTLLGKQVTLSLVEPMGCTSTLAVTSQKLLPVGPDGRHSFVVCLHVDLESLEIKCSNPQVQLI 1225

  Fly  1029 ME-------VVNNFQRNLDLVLSSTRPRDRMGSIGG----------------------------G 1058
            .|       |.:..|:..:|..||..|....|.|.|                            |
Mouse  1226 YELADTMSKVWSKIQKRGNLSPSSVYPETVAGPIPGSPVWSSVGTAPPDTSTCSPSADIGTTTEG 1290

  Fly  1059 DGI-------------------------------------KRTLNVILEDTE----EIMTTDQMK 1082
            |.:                                     |.|:.:...|.|    |:....:::
Mouse  1291 DSVQAGDDSPFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATVKLFAPDLEKKGTEVCMVSELE 1355

  Fly  1083 RRKKTRRTHVVET-VKVRVIA-NLDQV--------------GLVLTGRKRPI------------- 1118
            ....:.....|.| ||.:|.: ::|..              |:.|..:::|:
Mouse  1356 DLSASIDVQDVYTKVKCKVESFSIDHYQSRPGEGWQSGHFEGVFLQCKEKPVTTTKLLDGAHQQH 1420

  Fly  1119 ----------AEMNVKKFVSSLIIKSSYTEVNIGLKDIQVLDLNPYTIHKNILSIVGKDAFNC-- 1171
                      ...||:..::|...:.|:.:::.||     :|.:|:.:|:.:||....|...|
Mouse  1421 GFLSLTYTKAVTKNVRHKLTSRNERRSFYKLSEGL-----MDGSPHFLHEILLSAQAFDIVVCFP 1480

  Fly  1172 -----QIVIYNK-----EETQDYNSDDMKI-TVDIGCMKIIFLNWFVAGVMNFLNNFTAAQATIS 1225
                 ..|.:.|     .|.:..:...|:. |:....:.:|::|..|..:  |:......|:|:
Mouse  1481 LLNAIASVFHTKLPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRI--FVPQTEETQSTV- 1542

  Fly  1226 QAGAAAAESARQKAMDAYETATRMKLNIRIKAPIIIVPIG----SQDRNALLLDLGLLELTNNTV 1286
                |..::|::..|       .:|:.....||....|:|    .:|.....|:||:|....:.:
Mouse  1543 ----AVNQAAKEDTM-------VLKVGSIAMAPQADNPLGRSVLRKDIYQKALNLGILRDPGSEI 1596

  Fly  1287 EVAVAEEERLAVIDEIKLQICDVKISKIVLLDGNES----TVDEVDAEVGFLSKFNM-------- 1339
                  |:|...||...:.|...:..::....|:.|    |..|.:::...| ::||
Mouse  1597 ------EDRQYQIDLQSINIGTAQWDQLKPEKGSGSGGVPTESERNSQNPAL-EWNMASSIQRHQ 1654

  Fly  1340 -----MNPMSCTLSI----------TRNLSYTWYRDVPELNLSGRLKSIELTLFADDYALV---- 1385
                 :.|:....|:          |:.:|.. ...:.|:.:.|....:.:|...|.:..|
Mouse  1655 ERRAILTPILTDFSVRITGAPAIIFTKIISQE-NLHMEEILVCGHSLEVNITTNLDFFLSVAQVQ 1718

  Fly  1386 ----MLVLNRNLNEGLEEFPPSEEAPQEAQVRPERRNSRAGRLSRT------VQVSPIREKIHES 1440
                ::|.|..   |||   ||.:|.:.::...::.::..|..:.|      .|.|.|..   :|
Mouse  1719 LLHQLIVANMT---GLE---PSTKATEISKQEQKKVDTFDGGTAETSSRYSGAQDSGIGS---DS 1774

  Fly  1441 IKFNFQFDGVVINLMEGEGAG---LAR---------------FGIYFLSVKGTKLDNGTLSTSVV 1487
            :|..      ::.:.:..||.   :||               |.|:   :..:::...|.| ||.
Mouse  1775 VKIR------IVQIEQYSGASQHRIARPSHQSSIVKNLNFIPFDIF---ITASRISLMTYS-SVA 1829

  Fly  1488 LCNIQMDDMRSNSKSQIRQYLSRKDWVQPKLDTD--EIIDACYNERNFMVDVTAIIKEDDTFA-- 1548
            |...::.:.:.:.|:. |.:|:..:     :|:|  :...||.:    ||.....:....:|:
Mouse  1830 LPKFKLPEQKEDGKTG-RTFLNLAE-----VDSDVAKPNQACVS----MVTAEDPLSSSTSFSSG 1884

  Fly  1549 -EVRVRGFDLIVCIDFLLKLTTFLTLPPEENPRESVYIKPAPVSETARDTKHSIRSSAILAAQEL 1612
             :|||                  |:|       ||::.              |.||||..|....
Mouse  1885 KKVRV------------------LSL-------ESLHA--------------STRSSARQALGVT 1910

  Fly  1613 VPVESSSHEVPNRKMNLILH--IDEPDIILVENLEDLNTSCIIFNAQ---VHLNYR--------- 1663
            |..:.......:.:::|.||  :.:|.::|..:.........||:|.   |..:|.
Mouse  1911 VVRQPGRRGTGDLELDLFLHLIVSQPSLLLSCHHRKQRVEVSIFDAMLKGVPSDYTCTDPGKTLP 1975

  Fly  1664 ----------------------------SINDKQIVNGQIDALKMYMCAFLPERREMT------- 1693
                                        :::.|..:||..|   :|:....|.:..::
Mouse  1976 EASDYNIVWLQTVPGETDSKSGIPPSLVTLHIKDFLNGPAD---IYLDVSKPLKANLSFTKLDQI 2037

  Fly  1694 RHYI-----LHPCVISLQGSTPEEEGMHISLKLSDIIINVSPATIELLNKAMLSVSSGTMTKCAI 1753
            .|::     .|....|.:.|||           ||.|:|:....:....:..|   |.|...|..
Mouse  2038 NHFLKKIKKAHSSAHSKETSTP-----------SDSILNMDEPPVPKCYRGKL---SKTKVHCDE 2088

  Fly  1754 AEESRNYSNLWHQHHFHSRTYWFTKVEQGVDALEAEQRSVSTDNEKQKTEKCVI----------- 1807
            |:::....|:|.      ....|.||     ::...|..||.:......:.||:
Mouse  2089 AQKTSFQENIWR------AISCFQKV-----SVHTTQIVVSMETVPHPHKPCVLASLSNLNGSLT 2142

  Fly  1808 -----EIPSITLVIESGVGYYTKPLISL-DTRITAVFNNWSRSLTAHGSLTLNMNYYNQALAEWE 1866
                 ::|..:|    |..:    |:|: |..:.......||.|....|.|:|:.      |:|
Mouse  2143 VKAAQKVPGASL----GSSF----LLSIHDVLLKTSLKERSRILIGPFSATVNLE------AKW- 2192

  Fly  1867 PIIELNEVIGRNGVREYTPWELKFEMGMEKVQSELEDDAEQ---QAMHMNIHSAETLEITLSKTC 1928
                 .:..|..|.::..|          |:..:|.....|   ...|:|              |
Mouse  2193 -----CKHSGNPGPQQSIP----------KISMDLRGGLLQVFWGQEHLN--------------C 2228

  Fly  1929 LGLLSELAEAFSQAIDQNGLTKPDIV--APYVLENDTGFDVNL---NLRKGIFT----------- 1977
            |.||.||...:.|. .::.:..|:..  .|..:|....|....   :||.|||.
Mouse  2229 LALLHELFNGYLQE-GKSEMPVPESAPQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQDAESLKLP 2292

  Fly  1978 -LHEVHRGGTPVGANSTLLMVAQSEE---------VDPSVIKTCTISTGGRAYLQTKDLSTLSEE 2032
             ::||             |...::||         .:|.|:....|:.......:..|:||....
Mouse  2293 GVYEV-------------LFYNETEESPGMMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLG 2344

  Fly  2033 DSEDYTLYVTIG-----DINK------EIALPVSK------SDTRFFNLM----RSTSHEPWGII 2076
            |    .|.|..|     ::.|      |.:|..||      .|   .||:    :..|.:.|.|:
Mouse  2345 D----VLQVPCGLEYWDELQKVFVAFQEFSLSESKVCELQLPD---INLVHDQKKLVSSDLWRIV 2402

  Fly  2077 SEVKQEYGTT----KVNIHGVVSVHNHFTTGLNIYRRNPAPTA--------QCFEDIFVGRVRPG 2129
              :.....||    ..:..|..|......|          |||        .||...|
Mouse  2403 --LNNNQNTTDDQSSASESGSQSTCEPLVT----------PTALAACTRVDSCFTPWF------- 2448

  Fly  2130 EVFHVPLHAIYAESKDLFFSMRGYRRSVQGISWASNPSDLNYSHQLHCDPTNTFEPLIMNARRSK 2194
                ||...:..:...|.|.:                     .|  |.|...|..|..:....|.
Mouse  2449 ----VPSLCMSFQFAHLEFRL---------------------CH--HLDQLGTASPQYLQPFISD 2486

  Fly  2195 SEVYFENTNKYTLLSAFYTIHLRPPLYLR--NSLPINIQV---SVAGCSVRKEDGLDAQSSQRFV 2254
            ..|..|  .:|.::|     ...|.|:||  ||.|:..::   |...|.:.:...:..|:..:
Mouse  2487 KNVPSE--LEYMIIS-----FREPNLHLRQWNSGPVCQEIKFSSQMDCKLLECRNVTMQTVVK-- 2542

  Fly  2255 DRGYRKEDFLDYGEKPVNSGDVLHL--PTVRLASKGKESKSFLVVRLVQYLEKDWSCATEIWDYT 2317
                   .|...|:..::|..|..|  .||.:.|        ::|...|::....:.|.:.|.
Mouse  2543 -------PFGICGQMALSSDGVQKLLDSTVIVDS--------VLVNFGQHVVHSLNTAIQAWQ-- 2590

  Fly  2318 DDVITWTFSSYDSEMKVDMDLYVKTENRHGSLMLTLFSPFWMINKTGMMLTYKSETTSVEVL--- 2379
                                     :|:...:...:||.|.:.|.|...|.:....|...:|
Mouse  2591 -------------------------QNKCPEVEELVFSHFVICNDTQETLRFGQVDTDENILLAS 2630

  Fly  2380 YHPPEYSGPILFTFRDKLFFDKKKASIRI-----DNGQWSEKIPLDVAGSVGEVICFANNQKYPV 2439
            .|..:||      :|.    .|....:.|     .|.:|||...:|.||:      |....:|..
Mouse  2631 LHSHQYS------WRS----HKSPQLLHICIEGWGNWRWSEPFTVDHAGT------FIRTIQYKG 2679

  Fly  2440 GVHNHLTQ----NSLTKQITFIPFYIVCN-----------------------KCHFDIELQEQSR 2477
            ...:.:.:    :.:.|||......|:|:                       :.|||....:|..
Mouse  2680 RTASLIIKVRALSGVQKQIIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQKL 2744

  Fly  2478 PADPWLHLEPNEMEPL---------WPRN------DTKNNLVVRVDGKITPAFDFTEVICTLLKL 2527
            |:   ..||.||:..|         |.|:      .::.:.|::|.   |.......|.||:|.|
Mouse  2745 PS---YILENNELTELCVKAKGDEDWSRDVCLEPKASEYSTVIQVP---TSNSSIIYVWCTVLTL 2803

  Fly  2528 EDSKY-----------------------------------------GGINVDVQTTEGGV--YIT 2549
            |.:..                                         .|....:|..|..:  ::|
Mouse  2804 EPNSQVQQRMIVFSPLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGRGQENPLQNVEPDLVHHLT 2868

  Fly  2550 F---TDYKPADAPGLLINHTGKQIV--YHEKGTKNEHI-------LNAKSTIMYA---------- 2592
            |   .:|.|:|....:.....|||.  ....||.||.:       .:.:.|..|:
Mouse  2869 FQAREEYDPSDCAVPISTALIKQIATKIQPGGTVNEMLDEFYGPEKSQEPTWPYSNKDSDRNEQL 2933

  Fly  2593 --WDDPTGPKMLVFG----------------TNKEETDL-KRDGIGEVIMQDGGKVLW-VSFLDG 2637
              ||.|...|:.::.                .|:.:.|| ..:|...|:....||::. .:|.:.
Mouse  2934 SQWDSPMRVKLSIWKPYVRTLLIELLPWALLINQSKWDLWLFEGEKIVLQVPAGKIIIPPNFQEA 2998

  Fly  2638 LQRVLLFTENESIANRTESTASLQSITQS------------------IDLRI------------- 2671
            .| :.::.||.:..::|.:...:.::|..                  :|..|
Mouse  2999 FQ-IGIYWENTNTVHKTLAIKLVHNLTSPKWKDGGNGEVVTLDEEAFVDAEIRLGAFPGHQKLCQ 3062

  Fly  2672 --------HGIGL-------SVINNETGLDILYL------------------------------- 2690
                    |||.:       :|||| |...|:|.
Mouse  3063 FCISSMVQHGIQVIQIEDKTTVINN-TPYQIVYKPHLAISNSYSGKEHCHVPDSATFSICPGGEH 3126

  Fly  2691 -GVTSSGI-IWE-SKKVTKNRFKELTINENALLEIEYQKYLVHKSVNDVQTYKL----DNKFPID 2748
             .|.||.: .|: :..|..:.....|:.:..||     .:......:..|.:.|    ..:||..
Mouse  3127 PAVRSSSLPCWDVTPAVGSSELDTATLQKQILL-----GFSPVPGADSAQCWSLPAIIGGEFPRQ 3186

  Fly  2749 -------------FDLMILKKTVERNLRRSFYPAIWLSRKSSP---FQSQLHVKINRIQVDNQFL 2797
                         |....:..|.:.:|..::   |.||...||   |.::..|.:  :..:|...
Mouse  3187 SVAVPFGTGRENGFCTRAIALTYQEHLGVTY---ITLSEDPSPRVVFHNRCPVPM--LMKENIRD 3246

  Fly  2798 DPIFPVVLAPIPPPKSV-------------ASTTSLKP--FIECSMVQRIMP--------NSTVR 2839
            .|.|.|....|||..||             ..|..|.|  |:....::.:..        ||...
Mouse  3247 IPKFDVYCKKIPPESSVHHELYHQIISYPDCKTKDLLPSLFLRIDSMEEMTAEWSDPVDINSQGT 3311

  Fly  2840 Q------FKY-----------------------------ARILIQEFLFKVDLNFLTAIAEMFAK 2869
            |      |.|                             :|.|.:...|::   |:|.::...:.
Mouse  3312 QVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPIFTSTSRALERMVTFRM---FITQLSLAVSD 3373

  Fly  2870 EVSDEAAAKQFRQDVESI-------------ELPLSAFFEEHSLEE-------QKSFYD--NLH- 2911
            :::.:|.::..|..::::             |.|.|:||:.:.:|.       ....|:  |.|
Mouse  3374 DLTHQAPSELLRLTLDNVFLHVSPVPALLPGEEPPSSFFQLYGVEVYCGDLQLDNQLYNKSNFHF 3438

  Fly  2912 -----------------------------------------------------------LGPLKI 2917
                                                                       |.|.::
Mouse  3439 AVLVCQGERTDPAQYSRVQSLLVSSKALEEYKENCFIKLCLTVSEGKDILLDVSEFTFELKPARL 3503

  Fly  2918 HVS-----FSMAGSDTKALPG---------FLGSLVQGVGVT---LTDVNDVVFR---------- 2955
            :|.     :.....||...|.         |.|..|..|.||   ...||.|..|
Mouse  3504 YVEDTFVYYIKTLFDTYLPPSRMSGHHAQLFTGQQVLPVQVTQHAKALVNAVKLRKLLIQPVNLL 3568

  Fly  2956 -----------------LAF--FEREYQFFSQKQLINEITSHYTGQALKQLYVLVLGLDVLGNPY 3001
                             |:|  |||...|.:.:||::.:..||...||.:...:|..|::||:|.
Mouse  3569 ISIHASLKLYIASDHTPLSFSVFERGPVFTTARQLVHALAMHYAAGALFRAGWVVGSLEILGSPA 3633

  Fly  3002 GLVVGLKKGVEDLFYEPFQGAIQGPGEFAEGLVLGVKSLFGHTVGGAAGAVSKITGAMGKGLAAL 3066
            .||..:..|:.|.|..|::|..:|||.|..|:..|..|...|...||..:::.:..::.:.:..|
Mouse  3634 SLVRSIGNGISDFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRL 3698

  Fly  3067 TFDEDYQKKRRQGIQNKPKNFHEGLARSSKGLVMGFVDGVTGVVTKPV---------TGARDNGV 3122
            :.||::..::.:..:..|::..|||.:....|.:..:..:.|:|.:|:         ..:..:..
Mouse  3699 SLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKA 3763

  Fly  3123 EGFFKGLGKGAIGLVARPTAGVVDFASGSFEAVKRAADASEDVK-RMRPPRF-------QHYDFV 3179
            :|...|:|||.:|:..:|..|..:..|.:...:...|..|:..| |.:|...       .|..:|
Mouse  3764 KGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRCQPTHLYADQAPNSHVKYV 3828

  Fly  3180 L-------RP-------YCLMEATGNK----------------IMKETDKGKFATTDNFIHCEEI 3214
            .       ||       ..|:..:|.:                |.::|.:..|..|:  |.|.:.
Mouse  3829 WKMLQSLGRPEVHMALDVVLVRGSGQEHEGCLLLTSEVLFVVSISEDTQQQAFPITE--ISCAQD 3891

  Fly  3215 IQKSEYLVV 3223
            .:::..|.|
Mouse  3892 TKQNNLLTV 3900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13	NP_001260781.1	Chorein_N	4..113	CDD:315323	32/109 (29%)
		VPS13	140..370	CDD:318996	52/287 (18%)
		VPS13_mid_rpt	574..807	CDD:318998	46/289 (16%)
		SHR-BD	2349..2600	CDD:310922	69/367 (19%)
		VPS13	<2701..3232	CDD:330393	141/776 (18%)
		VPS13_C	2904..3074	CDD:318997	56/277 (20%)
Vps13b	NP_796125.2	Chorein_N	3..102	CDD:315323	31/98 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..133		3/32 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1262..1303		2/40 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1616..1637		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1735..1770		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2048..2067		9/29 (31%)
		SHR-BD	<2605..>2685	CDD:310922	21/95 (22%)
		VPS13_C	3557..3703	CDD:318997	37/145 (26%)
		ATG_C	3705..3809	CDD:312735	20/103 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930